ମେପ୍ରୋବାମେଟ

ମେପ୍ରୋବାମେଟ
Clinical data
Trade names	Miltown, Equanil, Meprospan, others
AHFS/Drugs.com	monograph
MedlinePlus	a682077
Pregnancy; category	AU: C ; US: D (Evidence of risk) ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: Schedule IV ; DE: Anlage II (Prohibited) ; US: Schedule IV ;
Pharmacokinetic data
Bioavailability	?
Metabolism	Liver
Onset of action	Within an hour
Elimination half-life	10 hours
Excretion	Kidney
Identifiers
	IUPAC name [2-(carbamoyloxymethyl)-2-methyl-pentyl] carbamate;
ECHA InfoCard	100.000.306
Chemical and physical data
Formula	C9H18N2O4
Molar mass	218.250
3D model (JSmol)	Interactive image;
Density	1.229 g/cm3
Melting point	105 to 106 °C (221 to 223 °F)
Boiling point	200 °C (392 °F) to 210 °C (410 °F)
	SMILES O=C(N)OCC(C)(CCC)COC(N)=O;
	InChI InChI=1S/C9H18N2O4/c1-3-4-9(2,5-14-7(10)12)6-15-8(11)13/h3-6H2,1-2H3,(H2,10,12)(H2,11,13) ; Key:NPPQSCRMBWNHMW-UHFFFAOYSA-N ;
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ମେପ୍ରୋବାମେଟ, ଏକ ବେପାର ନାମ ମିଲଟାଉନ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଉଦ୍‌ବେଗ ବାତ, ଏବଂ ପ୍ରଶାନ୍ତି ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୧] ଔଷଧର ପ୍ରଭାବ ଏକ ଘଣ୍ଟା ମଧ୍ୟରେ ଆରମ୍ଭ ହୁଏ ।^[୧] ଔଷଧର ସ୍ୱଳ୍ପ ମିଆଦି ବ୍ୟବହାରକୁ ସମର୍ଥନ କରାଯାଏ ।^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ଛାତି ଧଡ଼ଧଡ଼ ହେବା, ନିମ୍ନ ରକ୍ତଚାପ, ନିଦ୍ରାଳୁ, ଦୁର୍ବଳ ସମନ୍ୱୟ ଏବଂ ଆପ୍ଲାଷ୍ଟିକ୍ ରକ୍ତହୀନତା ହୋଇପାରେ ।^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅପବ୍ୟବହାର ଏବଂ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ହୋଇପାରେ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୧] ଏହା ଏକ କାର୍ବାମେଟ୍ ଶ୍ରେଣୀର ଔଷଧ ।^[୨]

୧୯୦୫ ମସିହାରେ ଚିକିତ୍ସା ବ୍ୟବହାର ନିମନ୍ତେ ମେପ୍ରୋବାମେଟ ଆବିଷ୍କୃତ ହୋଇଥିଲା ।^[୩] ୟୁରୋପରେ ଏହାର ଅନୁମୋଦନ ୨୦୧୨ ମସିହାରେ ପ୍ରତ୍ୟାହାର କରାଯାଇଥିଲା ।^[୪] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ଏହାର ବ୍ୟବ‌ହାର ନିମନ୍ତେ ମାସକୁ ପ୍ରାୟ ୧୬୦ ଡଲାର ଖର୍ଚ୍ଚ ହୋଇଥାଏ ।^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ଏହା କେବଳ ସ୍ୱତନ୍ତ୍ର ଅର୍ଡରଦ୍ୱାରା ଉପଲବ୍ଧ ହୁଏ ଏବଂ ଏହା କମ୍ ଉପଯୁକ୍ତ ଔଷଧ ବୋଲି ଧରାଯାଏ ।^[୬]

ଆଧାର

1 2 3 4 5 6 7 8 "Meprobamate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 31 December 2019. Retrieved 16 November 2021.
↑ Maronde, Robert F. (6 December 2012). Topics in Clinical Pharmacology and Therapeutics (in ଇଂରାଜୀ). Springer Science & Business Media. p. 420. ISBN 978-1-4612-4864-4. Archived from the original on 16 November 2021. Retrieved 16 November 2021.
↑ Wallace, Edwin R.; Gach, John (13 April 2010). "History of Psychiatry and Medical Psychology: With an Epilogue on Psychiatry and the Mind-Body Relation" (in ଇଂରାଜୀ). Springer Science & Business Media. Archived from the original on 16 November 2021. Retrieved 16 November 2021.
↑ "Questions and answers on the suspension of the marketing uthorisations for oral meprobamate-containing medicines" (PDF). 2012-01-19. Archived from the original (PDF) on 2014-12-21. Retrieved 2012-01-20.
1 2 "Meprobamate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 November 2016. Retrieved 16 November 2021.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 365. ISBN 978-0857114105.

[AHFS2021-1] 1 2 3 4 5 6 7 8 "Meprobamate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 31 December 2019. Retrieved 16 November 2021.

[Mar2012-2] Maronde, Robert F. (6 December 2012). Topics in Clinical Pharmacology and Therapeutics (in ଇଂରାଜୀ). Springer Science & Business Media. p. 420. ISBN 978-1-4612-4864-4. Archived from the original on 16 November 2021. Retrieved 16 November 2021.

[3] Wallace, Edwin R.; Gach, John (13 April 2010). "History of Psychiatry and Medical Psychology: With an Epilogue on Psychiatry and the Mind-Body Relation" (in ଇଂରାଜୀ). Springer Science & Business Media. Archived from the original on 16 November 2021. Retrieved 16 November 2021.

[EMA2012-4] "Questions and answers on the suspension of the marketing uthorisations for oral meprobamate-containing medicines" (PDF). 2012-01-19. Archived from the original (PDF) on 2014-12-21. Retrieved 2012-01-20.

[GX2021-5] 1 2 "Meprobamate Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 November 2016. Retrieved 16 November 2021.

[BNF81-6] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 365. ISBN 978-0857114105.

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