ଭୋରିକୋନାଜୋଲ

ଭୋରିକୋନାଜୋଲ
Clinical data
Pronunciation	/vɒrɪˈkɒnəzoʊl/ vorr-i-KON-ə-zohl
Trade names	Vfend, others
Synonyms	(αR,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
AHFS/Drugs.com	monograph
MedlinePlus	a605022
data	EU EMA: yes; US FDA: Voriconazole;
Pregnancy; category	D;
Routes of; administration	IV, by mouth (tablets, by mouth suspension)
ATC code	J02AC03 (WHO) ;
Legal status
Legal status	℞ (Prescription only);
Pharmacokinetic data
Bioavailability	96% (oral administration)
Protein binding	58%
Metabolism	Liver: CYP2C19 (significant involvement), also CYP2C9, CYP3A4
Metabolites	Voriconazole N-oxide (major; minimal antifungal activity)
Elimination half-life	Dose-dependent
Excretion	Urine (80–83%)
Identifiers
	IUPAC name (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol;
CAS Number	137234-62-9 ;
PubChem CID	71616;
DrugBank	DB00582 ;
ChemSpider	64684 ;
UNII	JFU09I87TR;
KEGG	D00578 ;
ChEBI	CHEBI:10023 ;
ChEMBL	CHEMBL638 ;
ECHA InfoCard	100.157.870
Chemical and physical data
Formula	C16H14F3N5O
Molar mass	349.311 g/mol
3D model (JSmol)	Interactive image;
	SMILES Fc1cncnc1[C@@H]([C@@](O)(c2ccc(F)cc2F)Cn3ncnc3)C;
	InChI InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1 ; Key:BCEHBSKCWLPMDN-MGPLVRAMSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Voriconazole

ଭୋରିକୋନାଜୋଲ (ଇଂରାଜୀ ଭାଷାରେ Voriconazole, ଏକ ବିକ୍ରୟ ନାମ ଭିଫେଣ୍ଡ/ Vfend) ଏକ କବକ ବିରୋଧୀ ଔଷଧ (antifungal medication) ଯାହା ଅନେକ ସଂଖ୍ୟକ କବକ ସଂକ୍ରମଣର (fungal infections) ଚିକିତ୍ସା ନିମନ୍ତେ ଦିଆଯାଏ ।^[୩] ଆସପରଜିଲୋସିସ (aspergillosis), କ୍ୟାଣ୍ଡିଡିଆସିସ୍, କ‌କସିଡାୟୋଡୋମାଇକୋସିସ (coccidioidomycosis), ହିସ୍ଟୋପ୍ଲାଜମୋସିସ (histoplasmosis), ପେନିସିଲିଓସିସ(penicilliosis) ଇତ୍ୟାଦି ରୋଗ ଓ ସେଡୋସ୍ପୋରିଅମ (Scedosporium) ତ‌ଥା ଫୁସାରିଅମ (Fusarium) ସଂକ୍ରମଣରେ ଦିଆଯାଏ । ^[୩] ଏହି ଔଷଧ ପାଟିରେ ବା ଶିରାଭ୍ୟନ୍ତରରେ (injection into a vein) ଦିଆଯାଏ । ^[୩]

ଭୋରିକୋନାଜୋଲର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଦୃଷ୍ଟି ସମସ୍ୟା, ଅଇ, ଉଦର ଯନ୍ତ୍ରଣା, ରାସ, ମୁଣ୍ଡବିନ୍ଧା ଓ ହାଲୁସିନେସନ ଦେଖାଯାଇପାରେ (seeing or hearing things that are not present) ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ଶିଶୁର ହାନୀ ହୋଇପାରେ ।^[୩] ଏହା ଟ୍ରିଆଜୋଲ (triazole) ଶ୍ରେଣୀର ଏକ ଔଷଧ ।^[୩] ଏହା କୋଷ ପରଦାକୁ (cell membrane) ବା କବକର ମେଟାବୋଲିଜ୍ମ (metabolism) ପ୍ରଭାବିତ କରିପାରେ ।^[୩]

ଭୋରିକୋନାଜୋଲ ସନ ୨୦୦୨ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୪] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୫] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହେବାକୁ ଏହା ସ୍ୱୀକୃତିପ୍ରାପ୍ତ ହୋଇଛି ।^[୬] ସନ ୨୯୧୭ରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହି ଔଷଧ ବାବଦ ଦୈନିକ ପ୍ରାୟ ୧୪.୮୬ ଆମେରିକୀୟ ଡଲାର ଖର୍ଚ୍ଚ ହୁଏ ।^[୭]

ଆଧାର

↑ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names (Rec. INN): List 36" (PDF). WHO Drug Information. World Health Organization. 10 (3): 162. 1996. Retrieved 6 November 2016.
↑ "US voriconazole label" (PDF). FDA. June 2017. Retrieved 30 July 2017. For label updates see FDA index page for NDA 021630
1 2 3 4 5 6 7 "Voriconazole". The American Society of Health-System Pharmacists. Retrieved 8 December 2017.
↑ Kendig, Edwin L.; Wilmott, Robert W.; Chernick, Victor (2012). Kendig and Chernick's Disorders of the Respiratory Tract in Children (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 539. ISBN 1437719848.
↑ "WHO Model List of Essential Medicines (20th List)" (PDF). World Health Organization. March 2017. Retrieved 29 June 2017.
↑ "Generic Vfend Availability". Drugs.com. Retrieved 10 December 2017.
↑ "NADAC as of 2017-12-06". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2017-12-10. Retrieved 10 December 2017.

[INN-1] "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names (Rec. INN): List 36" (PDF). WHO Drug Information. World Health Organization. 10 (3): 162. 1996. Retrieved 6 November 2016.

[USlabel2017-2] "US voriconazole label" (PDF). FDA. June 2017. Retrieved 30 July 2017. For label updates see FDA index page for NDA 021630

[AHFS2017-3] 1 2 3 4 5 6 7 "Voriconazole". The American Society of Health-System Pharmacists. Retrieved 8 December 2017.

[4] Kendig, Edwin L.; Wilmott, Robert W.; Chernick, Victor (2012). Kendig and Chernick's Disorders of the Respiratory Tract in Children (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 539. ISBN 1437719848.

[WHO20th-5] "WHO Model List of Essential Medicines (20th List)" (PDF). World Health Organization. March 2017. Retrieved 29 June 2017.

[6] "Generic Vfend Availability". Drugs.com. Retrieved 10 December 2017.

[7] "NADAC as of 2017-12-06". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2017-12-10. Retrieved 10 December 2017.

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