ଭାଲାସାଇକ୍ଲୋଭିର

ଭାଲାସାଇକ୍ଲୋଭିର
Clinical data
Trade names	Valtrex, Zelitrex, others
AHFS/Drugs.com	monograph
MedlinePlus	a695010
data	US DailyMed: Valacyclovir;
Pregnancy; category	AU: B3 ; US: B (No risk in non-human studies) ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	55%
Protein binding	13–18%
Metabolism	Liver (to aciclovir)
Elimination half-life	<30 minutes (valaciclovir);; 2.5–3.6 hours (aciclovir)
Excretion	Kidney 40–50% (aciclovir),; faecal 47% (aciclovir)
Identifiers
	IUPAC name (S)-2-[(2-amino-6-oxo-6,9-dihydro-3H-purin-9-yl)methoxy]ethyl-2-amino-3-methylbutanoate;
ECHA InfoCard	100.114.479
Chemical and physical data
Formula	C13H20N6O4
Molar mass	୩୨୪.୩୪ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCCOCn1c2N\C(=N/C(=O)c2nc1)N)[C@@H](N)C(C)C;
	InChI InChI=1S/C13H20N6O4/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20)/t8-/m0/s1 ; Key:HDOVUKNUBWVHOX-QMMMGPOBSA-N ;
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ଭାଲାସିକ୍ଲୋଭିର, ଭାଲାସାଇକ୍ଲୋଭିର ମଧ୍ୟ ବନାନ କରାଯାଏ, ଏକ ଭୂତାଣୂରୋଧୀ ଔଷଧ ଯାହା ହର୍ପସ୍ ସିମ୍ପ୍ଲେକ୍‌ସ୍ କିମ୍ବା ହର୍ପିସ୍ ଜୋଷ୍ଟର (shingles)ର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୧] ବୃକ୍‌କ ପ୍ରତିରୋପଣ ପରେ ସାଇଟୋମେଗାଲୋଭୂତାଣୁ ସଂକ୍ରମଣ ପ୍ରତିରୋଧର ଉଚ୍ଚ ସଙ୍କଟ କ୍ଷେତ୍ରରେ ମଧ୍ୟ ବ୍ୟବହୃତ ହୁଏ | ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡ ବିନ୍ଧା ଏବଂ ବାନ୍ତି ହୋଇପାରେ | ^[୧] ଗୁରୁତର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବୃକ୍‌କ ସମସ୍ୟା ଦେଖାଯାଇପାରେ | ^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ନିରାପଦ ମନେହୁଏ | ^[୨] ଏହାକୁ ପ୍ରୋଡ୍ରଗ କୁହାଯାଏ ଯାହା ବ୍ୟକ୍ତିଙ୍କ ଶରୀରରେ ଆସାଇକ୍ଲୋଭିରରେ ପରିଣତ ହେବା ପରେ କାମ କରେ | ^[୨]

ଭାଲାସିକ୍ଲୋଭିର ୧୯୮୭ ମସିହାରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୯୫ ମସିହାର ଡାକ୍ତରୀ ବ୍ୟବହାରରେ ଆସିଥିଲା । ^[୩] ^[୪] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାସ ଯୋଗାଣ ଏନଏଚଏସକୁ ୨୦୧୯ ସୁଦ୍ଧା ପ୍ରାୟ £ ୩ ଖର୍ଚ୍ଚ କରିଥାଏ। ^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ $ ୨.୮୦ ଅଟେ। ^[୭] ୨୦୧୭ରେ, ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୫୨ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଚାରି ନିୟୁତରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା | ^[୮] ^[୯]

ଆଧାର

1 2 "Valacyclovir Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 17 March 2019.
1 2 3 4 5 "Valacyclovir Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 17 March 2019.
↑ Long, Sarah S.; Pickering, Larry K.; Prober, Charles G. (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 504. ISBN 9783527607495.
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 625–626. ISBN 9780857113382.
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 625–626. ISBN 9780857113382.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
↑ "Valacyclovir - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

[AHFS2019-1] 1 2 "Valacyclovir Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 17 March 2019.

[autogen1-2] 1 2 3 4 5 "Valacyclovir Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 17 March 2019.

[:0-3] Long, Sarah S.; Pickering, Larry K.; Prober, Charles G. (2012). Principles and Practice of Pediatric Infectious Disease. Elsevier Health Sciences. p. 1502. ISBN 978-1437727029.

[Fis2006-4] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 504. ISBN 9783527607495.

[BNF76-5] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 625–626. ISBN 9780857113382.

[autogen2-6] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 625–626. ISBN 9780857113382.

[NADAC2019-7] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[Top_300-8] "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.

[ClinCalc_Valacyclovir-9] "Valacyclovir - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

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