ନିଲୋଟିନିବ

ନିଲୋଟିନିବ
Clinical data
Trade names	Tasigna, others
Synonyms	AMN107
AHFS/Drugs.com	monograph
MedlinePlus	a608002
data	EU EMA: yes; US FDA: Nilotinib;
Pregnancy; category	AU: D ; US: D (Evidence of risk) ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	30%
Protein binding	98%
Metabolism	Liver (mostly CYP3A4-mediated)
Elimination half-life	15-17 hours
Excretion	Faeces (93%)
Identifiers
	IUPAC name 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)- 5-(trifluoromethyl)phenyl]-3- [(4-pyridin-3-ylpyrimidin-2-yl) amino]benzamide;
ECHA InfoCard	100.166.395
Chemical and physical data
Formula	C28H22F3N7O
Molar mass	୫୨୯.୫୩ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1ccc(cc1Nc2nccc(n2)c3cccnc3)C(=O)Nc4cc(cc(c4)n5cc(nc5)C)C(F)(F)F;
	InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37) ; Key:HHZIURLSWUIHRB-UHFFFAOYSA-N ;
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ନିଲୋଟିନିବ, ବିକ୍ରୟ ନାମ ଟାସିଗନା, ହେଉଛି ଏକ ଔଷଧ ଯାହା କ୍ରନିକ୍ ମାଇଲୋଜେନସ୍ ଲ୍ୟୁକେମିଆ (ସିଏମଏଲ/ CML)ର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ଯେଉଁଥିରେ ଫିଲାଡେଲଫିଆ କ୍ରୋମୋଜୋମ ଥାଏ | ^[୨] କ୍ରନିକ୍ ପର୍ଯ୍ୟାୟ ସିଏମଏଲର ପ୍ରାରମ୍ଭିକ କ୍ଷେତ୍ର ଓ ତ୍ୱରିତ ତ‌ଥା କ୍ରନିକ ପର୍ଯ୍ୟାୟ ସିଏମଏଲରେ ବ୍ୟବହୃତ ହୋଇପାରେ ଯାହା ଇମାଟିନିବକୁ ପ୍ରତିକ୍ରିୟା କରିନଥାଏ | ^[୩] ^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କମ୍ ପ୍ଲାଟଲେଟ, କମ୍ ଶ୍ୱେତ ରକ୍ତ କଣିକା, ରକ୍ତହୀନତା, ରାସ୍, ବାନ୍ତି, ତରଳ ଝାଡ଼ା ଏବଂ ଗଣ୍ଠି ଯନ୍ତ୍ରଣା ହୋଇପାରେ | ^[୪] ଅନ୍ୟାନ୍ୟ ଗୁରୁତର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କ୍ୟୁଟି ବିସ୍ତାର, ଆକସ୍ମିକ ମୃତ୍ୟୁ, ଅଗ୍ନାଶୟ ପ୍ରଦାହ ଏବଂ ଯକୃତ ସମସ୍ୟା ହୋଇପାରେ | ^[୫] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ପାଇଁ ଏହା ନିରାପଦ ନୁହେଁ | ^[୫] ନିଲୋଟିନିବ ହେଉଛି ଏକ ବିସିଆର-ଏବିଏଲ ଟାଇରୋସିନ କାଇନେଜ ଇନହିବିଟର ଏବଂ କର୍କଟ କୋଷ ମଧ୍ୟରେ ସିଗନାଲରେ ହସ୍ତକ୍ଷେପ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ | ^[୫]

୨୦୦୭ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ନିଲୋଟିନିବ ଅନୁମୋଦିତ ହୋଇଥିଲା । ^[୪] ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ତାଲିକାରେ ଏହାର ନାମ ଅଛି ।^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୧୮ ସୁଦ୍ଧା ମାସକୁ ୨,୪୩୩ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହେଉଛି | ^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶି ୨୦୧୯ ସୁଦ୍ଧା ୧୪,୩୬୮ ଆମେରିକୀୟ ଡଲାର ଅଟେ। ^[୮]

ଆଧାର

1 2 3 4 5 "Tasigna (nilotinib) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 17 July 2021. Retrieved 25 January 2014.
↑ "Nilotinib". National Cancer Institute (in ଇଂରାଜୀ). 1 February 2008. Archived from the original on 14 July 2021. Retrieved 14 November 2019.
↑ "Nilotinib". National Cancer Institute (in ଇଂରାଜୀ). 1 February 2008. Archived from the original on 14 July 2021. Retrieved 14 November 2019.
1 2 3 "Nilotinib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 July 2021. Retrieved 14 November 2019.
1 2 3 4 "Nilotinib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 July 2021. Retrieved 14 November 2019.
↑ "World Health Organization model list of essential medicines: 21st list 2019". 2019. {{cite journal}}: Cite journal requires |journal= (help)
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 960. ISBN 9780857113382.
↑ "Tasigna Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 December 2019. Retrieved 14 November 2019.

[MSR-1] 1 2 3 4 5 "Tasigna (nilotinib) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 17 July 2021. Retrieved 25 January 2014.

[NCI2019-2] "Nilotinib". National Cancer Institute (in ଇଂରାଜୀ). 1 February 2008. Archived from the original on 14 July 2021. Retrieved 14 November 2019.

[autogen2-3] "Nilotinib". National Cancer Institute (in ଇଂରାଜୀ). 1 February 2008. Archived from the original on 14 July 2021. Retrieved 14 November 2019.

[AHFS2019-4] 1 2 3 "Nilotinib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 July 2021. Retrieved 14 November 2019.

[autogen3-5] 1 2 3 4 "Nilotinib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 July 2021. Retrieved 14 November 2019.

[WHO21st-6] "World Health Organization model list of essential medicines: 21st list 2019". 2019. {{cite journal}}: Cite journal requires |journal= (help)

[BNF76-7] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 960. ISBN 9780857113382.

[Price2019-8] "Tasigna Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 December 2019. Retrieved 14 November 2019.

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