ଟ୍ରିଆଜୋଲାମ

ଟ୍ରିଆଜୋଲାମ
Clinical data
Trade names	Halcion, others
AHFS/Drugs.com	monograph
MedlinePlus	a684004
data	US DailyMed: Triazolam;
Pregnancy; category	AU: C ; US: X (Contraindicated) ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: Schedule IV ; DE: Rx-only/Anlage III ; UK: Class C ; US: Schedule IV ; UN: N IV ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	44% (oral route), 53% (sublingual), 98% (intranasal) []
Metabolism	Liver
Onset of action	30 min
Elimination half-life	1.5–5.5 hours
Duration of action	Up to 4 hrs
Excretion	Kidney
Identifiers
	IUPAC name 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine;
ECHA InfoCard	100.044.811
Chemical and physical data
Formula	C17H12Cl2N4
Molar mass	୩୪୩.୨୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES ClC1=CC=CC=C1C2=NCC3=NN=C(C)N3C4=CC=C(Cl)C=C42;
	InChI InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3 ; Key:JOFWLTCLBGQGBO-UHFFFAOYSA-N ;
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ଟ୍ରିଆଜୋଲାମ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ହାଲସିଅନ୍, ହେଉଛି ଏକ ବେଞ୍ଜୋଡାଏଜେପିନ (BZD) ଶ୍ରେଣୀର ଔଷଧ ଯାହା ନିଦ୍ରାହୀନତା ସମସ୍ୟା ନିମନ୍ତେ ସ୍ୱଳ୍ପ କାଲ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୪] ଏହା ୧୦ ଦିନରୁ ଅଧିକ ସମୟ ପାଇଁ ବ୍ୟବହାର କରିବାକୁ ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୪] ଏହାର ପ୍ରଭାବ ପ୍ରାୟ ୩୦ ମିନିଟରୁ ଆରମ୍ଭ ହୋଇ 4 ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ | ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ, ସମନ୍ୱୟ ଅଭାବ ଏବଂ ବାନ୍ତି ହୋଇପାରେ ।^[୪] ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସ୍ୱଳ୍ପ ଶ୍ୱାସକ୍ରିୟା, ଆତ୍ମହତ୍ୟା, ଆନାଫାଇଲକ୍ସିସ୍, ନିଶାଶକ୍ତ, ଉତ୍ତେଜନା ଏବଂ ନୂତନ ସ୍ମୃତି ଗଠନ କରିବାରେ ଅକ୍ଷମତା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୪] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ | ^[୪] ଏହା ଜିଏବିଏ (GABA) ନ୍ୟୁରୋଟ୍ରାନ୍ସମିଟରର ପ୍ରଭାବକୁ ବୃଦ୍ଧି କରି କାର୍ଯ୍ୟକ୍ଷମ ହେଉଥିବା ପରି ଜଣାଯାଏ ।^[୪]

ଟ୍ରିଆଜୋଲାମ ପ୍ରଥମେ ୧୯୭୦ରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୭୭ରେ ନେଦରଲ୍ୟାଣ୍ଡରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା କିନ୍ତୁ ୧୯୮୦ରେ ସେଠାକାର ବଜାରରୁ ପ୍ରତ୍ୟାହାର କରାଯାଇଥିଲା । ^[୫] ^[୬] ୧୯୮୨ ମସିହାର ମସିହାରେ ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ବିକ୍ରି ହେବାକୁ ଲାଗିଲା। ^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ୨୮୦ତମ ସାଧାରଣ ବିକ୍ରୟ ଔଷଧ । ^[୭] ^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ଡୋଜ ପିଛା ପ୍ରାୟ ୧ ଡଲାର ଖର୍ଚ୍ଚ ହୁଏ | ^[୯] ୧୯୩୩ ମସିହାରେ ବ୍ରିଟେନରେ ଏହାର ବିକ୍ରୟ ନିଷେଧ କରାଯାଇଛି ।^[୧୦]

ଆଧାର

1 2 "Triazolam (Halcion) Use During Pregnancy". Drugs.com. 18 September 2020. Archived from the original on 26 October 2020. Retrieved 24 October 2020.
↑ Lui, CY; Amidon, GL; Goldberg, A (1991). "Intranasal absorption of flurazepam, midazolam, and triazolam in dogs". J Pharm Sci. 80 (12): 1125–9. doi:10.1002/jps.2600801207. PMID 1815070.
1 2 3 Newman, Michael G.; Takei, Henry; Klokkevold, Perry R.; Carranza, Fermin A. (29 May 2018). Newman and Carranza's Clinical Periodontology E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 871. ISBN 978-0-323-53323-2. Archived from the original on 23 September 2021. Retrieved 19 September 2021.
1 2 3 4 5 6 7 "Triazolam Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 September 2020. Retrieved 17 September 2021.
↑ Halcion : an independent assessment of safety and efficacy data. Washington, D.C.: National Academy Press. 1997. p. Chp 3. ISBN 9780309059763. Archived from the original on 22 September 2020. Retrieved 19 September 2021.
1 2 Shorter, Edward (2005). "B". A Historical Dictionary of Psychiatry. Oxford University Press. ISBN 9780190292010. Archived from the original on 2021-08-28. Retrieved 2020-09-20.
↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
↑ "Triazolam - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.
↑ "Triazolam Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 9 November 2016. Retrieved 19 September 2021.
↑ Dyer, C (13 February 1999). "Edinburgh university fined forlack of safety checks". BMJ (Clinical research ed.). 318 (7181): 418B. doi:10.1136/bmj.318.7181.418b. PMID 9974447.

[Drugs.com_pregnancy-1] 1 2 "Triazolam (Halcion) Use During Pregnancy". Drugs.com. 18 September 2020. Archived from the original on 26 October 2020. Retrieved 24 October 2020.

[2] Lui, CY; Amidon, GL; Goldberg, A (1991). "Intranasal absorption of flurazepam, midazolam, and triazolam in dogs". J Pharm Sci. 80 (12): 1125–9. doi:10.1002/jps.2600801207. PMID 1815070.

[New2018-3] 1 2 3 Newman, Michael G.; Takei, Henry; Klokkevold, Perry R.; Carranza, Fermin A. (29 May 2018). Newman and Carranza's Clinical Periodontology E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 871. ISBN 978-0-323-53323-2. Archived from the original on 23 September 2021. Retrieved 19 September 2021.

[AHFS2021-4] 1 2 3 4 5 6 7 "Triazolam Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 September 2020. Retrieved 17 September 2021.

[5] Halcion : an independent assessment of safety and efficacy data. Washington, D.C.: National Academy Press. 1997. p. Chp 3. ISBN 9780309059763. Archived from the original on 22 September 2020. Retrieved 19 September 2021.

[Ed2005-6] 1 2 Shorter, Edward (2005). "B". A Historical Dictionary of Psychiatry. Oxford University Press. ISBN 9780190292010. Archived from the original on 2021-08-28. Retrieved 2020-09-20.

[7] "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.

[8] "Triazolam - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.

[9] "Triazolam Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 9 November 2016. Retrieved 19 September 2021.

[10] Dyer, C (13 February 1999). "Edinburgh university fined forlack of safety checks". BMJ (Clinical research ed.). 318 (7181): 418B. doi:10.1136/bmj.318.7181.418b. PMID 9974447.

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