ଟ୍ରାଇମିପ୍ରାମାଇନ

ଟ୍ରାଇମିପ୍ରାମାଇନ
Clinical data
Trade names	Surmontil, others
Synonyms	Trimeproprimine; IF-6120; IL-6001; RP-7162; 2'-Methylimipramine; β-Methylimipramine
AHFS/Drugs.com
MedlinePlus	a602010
data	US FDA: Trimipramine;
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ;
Routes of; administration	By mouth, intramuscular injection, intravenous
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	41%
Protein binding	94.9%
Metabolism	Liver
Elimination half-life	23–24 hours
Excretion	Kidney
Identifiers
	IUPAC name (±)-3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N,2-trimethylpropan-1-amine;
ECHA InfoCard	100.010.917
Chemical and physical data
Formula	C20H26N2
Molar mass	୨୯୪.୪୪ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1cc3c(cc1)CCc2c(cccc2)N3CC(C)CN(C)C;
	InChI InChI=1S/C20H26N2/c1-16(14-21(2)3)15-22-19-10-6-4-8-17(19)12-13-18-9-5-7-11-20(18)22/h4-11,16H,12-15H2,1-3H3 ; Key:ZSCDBOWYZJWBIY-UHFFFAOYSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Trimipramine

ଟ୍ରାଇମିପ୍ରାମାଇନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ସରମୋଣ୍ଟିଲ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ମୁଖ୍ୟତଃ ପ୍ରମୁଖ ଅବସାଦ ବେମାରୀ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୫] ଅନ୍ୟାନ୍ୟ ବ୍ୟବହାରରେ ପିଲାମାନଙ୍କ ଶୋଇବା ସମସ୍ୟା ଏବଂ ବିଛଣା ମୂତ୍ରତ୍ୟାଗ ଚିକିତ୍ସା ନିମନ୍ତେ ଦିଆଯାଏ ।^[୫] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୫] ଔଷଧ କାର୍ଯ୍ୟକ୍ଷମ ହେବାକୁ ଦୁଇ ସପ୍ତାହରୁ ଅଧିକ ଆବଶ୍ୟକ ହୋଇପାରେ ।^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରା, ଶୁଖିଲା ପାଟି, କୋଷ୍ଠକାଠିନ୍ୟ, ଛିଡ଼ା ହେବା ସହିତ ନିମ୍ନ ରକ୍ତଚାପ, ଏବଂ ଓଜନ ବୃଦ୍ଧି ହୋଇପାରେ ।^[୫] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରକ୍ତରେ ଉଚ୍ଚ ଶର୍କରା ସ୍ତର, ଯକୃତ ସମସ୍ୟା, ଆତ୍ମହତ୍ୟା ପ୍ରବଣତା ଏବଂ ଯୌନ ଅସୁବିଧା ହୋଇପାରେ।^[୬] ଏହା ଏକ ଟ୍ରାଇସାଇକ୍ଲିକ୍ ଆଣ୍ଟିଡେପ୍ରେସାଣ୍ଟ (TCA); ତଥାପି, ଏହା କିପରି କାର୍ଯ୍ୟ କରେ ତାହା ସମ୍ପୂର୍ଣ୍ଣ ସ୍ପଷ୍ଟ ନୁହେଁ ।^[୫]

୧୯୭୯ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ଚିକିତ୍ସାରେ ବ୍ୟବହାର ପାଇଁ ଟ୍ରାଇମିପ୍ରାମାଇନ ଅନୁମୋଦିତ ହୋଇଥିଲା ^[୫] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ୫୦ ମିଗ୍ରା ବିଶିଷ୍ଟ ୨୮ ବଟିକାର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୨୨୦ ପାଉଣ୍ଡ ଥିଲା ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୫୦ ଡଲାର ଥିଲା ।^[୭]

ଆଧାର

1 2 3 4 5 "PRODUCT INFORMATION SURMONTIL® Tablets and Capsules" (PDF). TGA eBusiness Services. Aspen Pharmacare Australia Pty Ltd. 28 November 2012. Archived from the original on 1 November 2016. Retrieved 30 November 2013.
1 2 3 4 5 "SURMONTIL (trimipramine maleate) capsule [Duramed Pharmaceuticals Inc]". DailyMed. Duramed Pharmaceuticals Inc. December 2012. Archived from the original on 4 July 2013. Retrieved 30 November 2013.
1 2 3 4 5 "Surmontil, Trimip (trimipramine) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 3 December 2013. Retrieved 30 November 2013.
1 2 3 4 5 "Trimipramine 50mg Capsules - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Zentiva. 19 November 2012. Archived from the original on 3 December 2013. Retrieved 30 November 2013.
1 2 3 4 5 6 7 "Trimipramine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 20 September 2021.
1 2 3 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 396. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Trimipramine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 June 2016. Retrieved 20 September 2021.

[TGA-1] 1 2 3 4 5 "PRODUCT INFORMATION SURMONTIL® Tablets and Capsules" (PDF). TGA eBusiness Services. Aspen Pharmacare Australia Pty Ltd. 28 November 2012. Archived from the original on 1 November 2016. Retrieved 30 November 2013.

[DM-2] 1 2 3 4 5 "SURMONTIL (trimipramine maleate) capsule [Duramed Pharmaceuticals Inc]". DailyMed. Duramed Pharmaceuticals Inc. December 2012. Archived from the original on 4 July 2013. Retrieved 30 November 2013.

[MSR-3] 1 2 3 4 5 "Surmontil, Trimip (trimipramine) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 3 December 2013. Retrieved 30 November 2013.

[EMC-4] 1 2 3 4 5 "Trimipramine 50mg Capsules - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Zentiva. 19 November 2012. Archived from the original on 3 December 2013. Retrieved 30 November 2013.

[AHFS2021-5] 1 2 3 4 5 6 7 "Trimipramine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 20 September 2021.

[BNF80-6] 1 2 3 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 396. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[7] "Trimipramine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 June 2016. Retrieved 20 September 2021.

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