ଟୋବ୍ରାମାଇସିନ

ଟୋବ୍ରାମାଇସିନ
Clinical data
Trade names	Tobrex, Tobi, others
Synonyms	47663, SPRC-AB01
AHFS/Drugs.com	Systemic: monograph; Eyes: monograph
MedlinePlus	a682660
data	EU EMA: yes; US DailyMed: Tobramycin;
Pregnancy; category	AU: D; B3 ; US: N (Not classified yet) ; ;
Routes of; administration	IV, IM, inhalation, eye drop
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Protein binding	< 30%
Identifiers
	IUPAC name (2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol;
ECHA InfoCard	100.046.642
Chemical and physical data
Formula	C18H37N5O9
Molar mass	467.515
3D model (JSmol)	Interactive image;
	SMILES C1[C@@H]([C@H]([C@@H]([C@H]([C@@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)N)O)O)O[C@@H]3[C@@H](C[C@@H]([C@H](O3)CN)O)N)N;
	InChI InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1 ; Key:NLVFBUXFDBBNBW-PBSUHMDJSA-N ;
(verify)

ଟୋବ୍ରାମାଇସିନ ହେଉଛି ଏକ ଆଣ୍ଟିବାୟୋଟିକ୍ ଔଷଧ ଯାହା ସେପ୍ସିସ୍, ମେନିଞ୍ଜାଇଟିସ୍, ମୂତ୍ରାଙ୍ଗ ସଂକ୍ରମଣ, ଓଷ୍ଟିଓମାୟେଲାଇଟିସ ଏବଂ ଫୁସଫୁସ ସଂକ୍ରମଣ ସହିତ ବିଭିନ୍ନ ସଂକ୍ରମଣର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୪]^[୫] ସୁଡୋମୋନାସ ସଂକ୍ରମଣ ନିମନ୍ତ ମଧ୍ୟ ଏହା ଦିଆଯାଏ ।^[୫] ଏହା ଶିରା କିମ୍ବା ମାଂସପେଶୀରେ ଇଞ୍ଜେକ୍ସନ ଆକାରରେ ଦିଆଯାଏ କିମ୍ବା ଫୁସଫୁସ ମଧ୍ୟକୁ ପ୍ରଶ୍ୱାସରେ ଦିଆଯାଇପାରେ। ^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶ୍ରବଣହାନୀ, ସନ୍ତୁଳନ ସମସ୍ୟା ଏବଂ କିଡନୀ ସମସ୍ୟା ହୋଇପାରେ ।^[୫] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପକ୍ଷାଘାତ ଏବଂ ଆନାଫାଇଲକ୍‌ସିସ୍ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୫] ବୃକ୍‌କ ସମସ୍ୟା ଥିବା ଲୋକଙ୍କୁ କମ ମାତ୍ରା ଔଷଧ ଦେବା ଆବଶ୍ୟକ ।^[୫] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ ।^[୫] ଏହା ଏକ ଆମିନୋଗ୍ଲାଇକୋସାଇଡ୍ ଔଷଧ ।^[୫]

ଔଷଧଟୋବ୍ରାମାଇସିନ୍ ୧୯୬୫ ମସିହାରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୭୪ରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୬] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । ^[୪] ଇଞ୍ଜେକ୍ସନ୍ ପାଇଁ ୮୦ ମିଗ୍ରା ଔଷଧର ମୂଲ୍ୟ £ ୫ଥିବାବେଳେ ପ୍ରଶ୍ୱାସରେ ଦିଆଯାଉଥିବା ଔଷଧର ମୂଲ୍ୟ ପ୍ରାୟ £ 780 ଅଟେ | ^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ପ୍ରଶ୍ୱାସପ୍ରାପ୍ତ ଔଷଧର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ 4,900 ଡଲାର ଥିଲା ।^[୭] ଏହା ସ୍ଟ୍ରେପ୍ଟୋମାଇସେସ ଟେନେବ୍ରାରିୟସରୁ ତିଆରି ।^[୫]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Tobramycin Use During Pregnancy". Drugs.com. 11 November 2019. Archived from the original on 9 August 2020. Retrieved 28 April 2020.
↑ ^୨.୦ ^୨.୧ "Tobramycin ophthalmic Use During Pregnancy". Drugs.com. 24 December 2019. Archived from the original on 13 April 2020. Retrieved 28 April 2020.
↑ "Tobramycin 40mg/ml Injection - Summary of Product Characteristics (SmPC)". (emc). 9 October 2018. Archived from the original on 9 August 2020. Retrieved 28 April 2020.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 547. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ ^୫.୬ ^୫.୭ "Tobramycin (Systemic) Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 January 2021. Retrieved 4 October 2021.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 507. ISBN 9783527607495. Archived from the original on 1 August 2020. Retrieved 20 September 2020. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
↑ "Tobramycin Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 16 January 2021. Retrieved 5 October 2021.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ "Tobramycin Use During Pregnancy". Drugs.com. 11 November 2019. Archived from the original on 9 August 2020. Retrieved 28 April 2020.

[Drugs.com_pregnancy_ophthalmic-2] ୨.୦ ^୨.୧ "Tobramycin ophthalmic Use During Pregnancy". Drugs.com. 24 December 2019. Archived from the original on 13 April 2020. Retrieved 28 April 2020.

[Tobramycin_SmPC-3] "Tobramycin 40mg/ml Injection - Summary of Product Characteristics (SmPC)". (emc). 9 October 2018. Archived from the original on 9 August 2020. Retrieved 28 April 2020.

[BNF80-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 547. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[AHFS2021-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ ^୫.୬ ^୫.୭ "Tobramycin (Systemic) Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 January 2021. Retrieved 4 October 2021.

[Fis2006-6] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 507. ISBN 9783527607495. Archived from the original on 1 August 2020. Retrieved 20 September 2020. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[7] "Tobramycin Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 16 January 2021. Retrieved 5 October 2021.

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