ଉରସୋଡିଅକ୍ସିକୋଲିକ ଅମ୍ଳ

ଉରସୋଡିଅକ୍ସିକୋଲିକ ଅମ୍ଳ
Clinical data
Trade names	Actigall, Urso, others
Synonyms	Ursodiol
AHFS/Drugs.com	monograph
MedlinePlus	a699047
data	EU EMA: yes; US DailyMed: Ursodiol;
Pregnancy; category	AU: B3 ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ; ℞ (Prescription only);
Identifiers
	IUPAC name 3α,7β-dihydroxy-5β-cholan-24-oic acid; OR; (R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-; 10,13-dimethylhexadecahydro-; 1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;
ECHA InfoCard	100.004.437
Chemical and physical data
Formula	C24H40O4
Molar mass	392.56
3D model (JSmol)	Interactive image;
Melting point	203 °C (397 °F)
	SMILES O=C(O)CC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]4[C@H]2[C@@H](O)C[C@@H]3C[C@H](O)CC[C@@]34C)C;
	InChI InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1 ; Key:RUDATBOHQWOJDD-UZVSRGJWSA-N ;
(verify)

ଉରସୋଡିଅକ୍ସିକୋଲିକ ଅମ୍ଳ (ଇଂରାଜୀ ଭାଷାରେ Ursodeoxycholic acid ( UDCA ), ଯାହାକୁ ursodiol ମଧ୍ୟ କୁହାଯାଏ) ଏକ ପ୍ରାକୃତିକ ଭାବରେ ତିଆରି ହେଉଥିବା ପିତ୍ତ ଅମ୍ଳ ଯାହା ଯକୃତ ଓ ପିତ୍ତ ନଳୀର କେତେକ ରୋଗର ଚିକିତ୍ସା ନିମନ୍ତେ ବ୍ୟବହୃତ ହୁଏ ।^[୪] ଏଥିରେ ପ୍ରାଥମିକ ବିଲିଆରି ସିରୋସିସ୍ ବା କୋଲାଞ୍ଜାଇଟିସ ରୋଗର ଚିକିତ୍ସା ଏବଂ ପିତାସ୍ମରୀ ରୋକିବା କିମ୍ବା ଭାଙ୍ଗିବା ନିମନ୍ତେ ବ୍ୟବ‌ହୃତ ହୁଏ ।^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା ଏବଂ ଫିକା ମଳ ହୋଇପାରେ ।^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପେଟ ଯନ୍ତ୍ରଣା, ବାନ୍ତି ଏବଂ ଦାଗ ରାସ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୨] ଅଳ୍ପ ସଂଖ୍ୟକ ଗର୍ଭଧାରଣରେ ବ୍ୟବହାର ପରେ ଏହା ଅପେକ୍ଷାକୃତ ନିରାପଦ ମନେହୁଏ ।^[୫] ଶରୀରରେ ଉର୍ସୋଡୋକ୍ସିଚୋଲିକ୍ ଏସିଡ୍ ସାଧାରଣତଃ ଅଳ୍ପ ପରିମାଣରେ ଦେଖାଯାଏ । ^[୪] କୋଲେଷ୍ଟ୍ରଲ୍ର ମୁକ୍ତି ଏବଂ ଗ୍ରହଣକୁ ଅବରୋଧ କରି ଏହା ଆଂଶିକ ଭାବରେ କାମ କରିବ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ। ^[୪]

୧୯୮୭ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଉରସୋଡିଅକ୍ସିକୋଲିକ ଅମ୍ଳ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ଭାଲୁ ପିତ୍ତରେ ଏହା ଥିବା ଦେଖାଯାଇଥିଲା ।^[୬]^[୭] ଏହା ଏକ ସାଧାରଣ ଔଷଧଭାବରେ ଉପଲବ୍ଧ ।^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ୫୦୦ ମିଗ୍ରା ୧୦୦ ବଟିକାର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ £୫୦ ଥିବାବେଳେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶି ପ୍ରାୟ ୧୮୦ ଡଲାର୍ ।^[୨] ^[୮]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Ursodiol Use During Pregnancy". Drugs.com. 4 November 2019. Archived from the original on 20 February 2020. Retrieved 20 February 2020.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 96. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Ursodeoxycholic acid 300mg Tablets - Summary of Product Characteristics (SmPC)". (emc). 10 July 2019. Archived from the original on 13 August 2020. Retrieved 29 April 2020.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Ursodiol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 7 May 2021. Retrieved 13 September 2021.
↑ "Ursodiol Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 February 2020. Retrieved 13 September 2021.
↑ Sneader, Walter (23 June 2005). Drug Discovery: A History (in ଇଂରାଜୀ). John Wiley & Sons. p. 273. ISBN 978-0-471-89979-2. Archived from the original on 22 September 2021. Retrieved 13 September 2021.
↑ Chivian, Eric; Bernstein, Aaron (2 June 2008). Sustaining Life: How Human Health Depends on Biodiversity (in ଇଂରାଜୀ). Oxford University Press. p. 227. ISBN 978-0-19-972120-7. Archived from the original on 22 September 2021. Retrieved 13 September 2021.
↑ "Ursodiol Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 16 January 2021. Retrieved 13 September 2021.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ "Ursodiol Use During Pregnancy". Drugs.com. 4 November 2019. Archived from the original on 20 February 2020. Retrieved 20 February 2020.

[BNF80-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 96. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[3] "Ursodeoxycholic acid 300mg Tablets - Summary of Product Characteristics (SmPC)". (emc). 10 July 2019. Archived from the original on 13 August 2020. Retrieved 29 April 2020.

[AHFS2021-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Ursodiol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 7 May 2021. Retrieved 13 September 2021.

[Preg2021-5] "Ursodiol Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 February 2020. Retrieved 13 September 2021.

[6] Sneader, Walter (23 June 2005). Drug Discovery: A History (in ଇଂରାଜୀ). John Wiley & Sons. p. 273. ISBN 978-0-471-89979-2. Archived from the original on 22 September 2021. Retrieved 13 September 2021.

[7] Chivian, Eric; Bernstein, Aaron (2 June 2008). Sustaining Life: How Human Health Depends on Biodiversity (in ଇଂରାଜୀ). Oxford University Press. p. 227. ISBN 978-0-19-972120-7. Archived from the original on 22 September 2021. Retrieved 13 September 2021.

[8] "Ursodiol Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 16 January 2021. Retrieved 13 September 2021.

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