ଇନସୁଲିନ ଲିସପ୍ରୋ

ଉଇକିପିଡ଼ିଆ‌ରୁ
ଇନସୁଲିନ ଲିସପ୍ରୋ
Clinical data
Trade namesHumalog, Liprolog, Admelog, others
SynonymsURLi, LY900014, LY-275585, insulin lispro-aabc
AHFS/Drugs.commonograph
MedlinePlusa697021
data
Pregnancy
category
Routes of
administration		Subcutaneous
Legal status
Legal status
Pharmacokinetic data
Onset of actionWithin 30 min[୩]
Duration of action~5 hrs[୩]
Chemical and physical data
FormulaC257H389N65O77S6
Molar mass5813.63
3D model (JSmol)
  • CCC(C)C(C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CS)C(=O)NC(CS)C(=O)NC(C(C)O)C(=O)NC(CO)C(=O)NC(C(C)CC)C(=O)NC(CS)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)N)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CS)C(=O)NC(CC(=O)N)C(=O)O)NC(=O)CN.CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CS)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CC2=CC=CC=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CC=C(C=C4)O)C(=O)NC(C(C)O)C(=O)NC(CCCCN)C(=O)N5CCCC5C(=O)NC(C(C)O)C(=O)O)NC(=O)C(C)NC(=O)C(CCC(=O)O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC6=CN=CN6)NC(=O)C(CO)NC(=O)CNC(=O)C(CS)NC(=O)C(CC(C)C)NC(=O)C(CC7=CN=CN7)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC8=CC=CC=C8)N
  • InChI=1S/C158H234N40O42S2.C99H155N25O35S4/c1-79(2)57-104(181-131(213)86(15)173-136(218)102(50-53-125(211)212)179-152(234)127(84(11)12)194-148(230)107(60-82(7)8)184-145(227)113(67-95-70-166-78-172-95)189-150(232)115(74-199)176-123(208)73-170-134(216)116(75-241)191-140(222)105(58-80(3)4)182-144(226)112(66-94-69-165-77-171-94)188-138(220)101(48-51-119(161)204)178-146(228)114(68-120(162)205)190-153(235)126(83(9)10)193-132(214)98(160)61-89-31-21-18-22-32-89)139(221)185-110(64-92-40-44-96(202)45-41-92)142(224)183-106(59-81(5)6)147(229)195-128(85(13)14)154(236)192-117(76-242)135(217)169-71-121(206)174-100(49-52-124(209)210)137(219)177-99(38-29-55-167-158(163)164)133(215)168-72-122(207)175-108(62-90-33-23-19-24-34-90)141(223)186-109(63-91-35-25-20-26-36-91)143(225)187-111(65-93-42-46-97(203)47-43-93)149(231)196-129(87(16)200)155(237)180-103(37-27-28-54-159)156(238)198-56-30-39-118(198)151(233)197-130(88(17)201)157(239)240;1-12-46(9)77(121-73(134)36-100)97(156)122-76(45(7)8)95(154)108-56(25-29-75(137)138)80(139)105-54(23-27-70(102)131)83(142)117-66(40-161)93(152)119-68(42-163)94(153)124-79(48(11)127)98(157)116-64(38-126)90(149)123-78(47(10)13-2)96(155)120-67(41-162)92(151)115-63(37-125)89(148)110-58(31-44(5)6)85(144)111-59(32-49-14-18-51(128)19-15-49)86(145)106-53(22-26-69(101)130)81(140)109-57(30-43(3)4)84(143)107-55(24-28-74(135)136)82(141)113-61(34-71(103)132)88(147)112-60(33-50-16-20-52(129)21-17-50)87(146)118-65(39-160)91(150)114-62(99(158)159)35-72(104)133/h18-26,31-36,40-47,69-70,77-88,98-118,126-130,199-203,241-242H,27-30,37-39,48-68,71-76,159-160H2,1-17H3,(H2,161,204)(H2,162,205)(H,165,171)(H,166,172)(H,168,215)(H,169,217)(H,170,216)(H,173,218)(H,174,206)(H,175,207)(H,176,208)(H,177,219)(H,178,228)(H,179,234)(H,180,237)(H,181,213)(H,182,226)(H,183,224)(H,184,227)(H,185,221)(H,186,223)(H,187,225)(H,188,220)(H,189,232)(H,190,235)(H,191,222)(H,192,236)(H,193,214)(H,194,230)(H,195,229)(H,196,231)(H,197,233)(H,209,210)(H,211,212)(H,239,240)(H4,163,164,167);14-21,43-48,53-68,76-79,125-129,160-163H,12-13,22-42,100H2,1-11H3,(H2,101,130)(H2,102,131)(H2,103,132)(H2,104,133)(H,105,139)(H,106,145)(H,107,143)(H,108,154)(H,109,140)(H,110,148)(H,111,144)(H,112,147)(H,113,141)(H,114,150)(H,115,151)(H,116,157)(H,117,142)(H,118,146)(H,119,152)(H,120,155)(H,121,134)(H,122,156)(H,123,149)(H,124,153)(H,135,136)(H,137,138)(H,158,159)/t86-,87+,88+,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,126-,127-,128-,129-,130-;46-,47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,76-,77-,78-,79-/m00/s1
  • Key:WNRQPCUGRUFHED-DETKDSODSA-N
  (verify)

ଇନସୁଲିନ ଲିସପ୍ରୋ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ହ୍ୟୁମାଲଗ ହେଉଛି ଏକ ଔଷଧ ଯାହା ମଧୁମେହ ଟାଇପ୍ ୧ ଏବଂ ଟାଇପ୍ ୨ ମଧୁମେହ ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | [୪] ସାଧାରଣତଃ ଏହାକୁ ଖାଇବା ସମୟରେ ଦିଆଯାଏ | [୩] ଏହା ଚର୍ମ ତଳ ଇଞ୍ଜେକସନ ଆକାରରେ କିମ୍ବା ଇନସୁଲିନ ପମ୍ପ ଆକାରରେ ବ୍ୟବହୃତ ହୁଏ ।| [୩] [୫] ପ୍ରଭାବ ଆରମ୍ଭ ସାଧାରଣତଃ ୩୦ ମିନିଟ୍ ମଧ୍ୟରେ ଘଟିଥାଏ ଏବଂ ପ୍ରାୟ ୫ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ | [୩] ଏନପିଏଚ ଇନସୁଲିନ ପରି ଏକ ଲମ୍ବା କାର୍ଯ୍ୟକ୍ଷମ ଇନସୁଲିନ୍ ମଧ୍ୟ ଆବଶ୍ୟକ ହୋଇପାରେ | [୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିମ୍ନ ରକ୍ତ ଶର୍କରା ହୋଇପାରେ | [୪] ଅନ୍ୟାନ୍ୟ ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କମ୍ ରକ୍ତ ପୋଟାସିୟମ୍ ହୋଇପାରେ | [୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଏବଂ ସ୍ତନ୍ୟପାନ କରାଇବା ସାଧାରଣତଃ ନିରାପଦ ଅଟେ | [୬] ଏହା ମାନବ ଦେହର ଇନସୁଲିନ ଭଳି କାମ କରେ ଯାହା ଯକୃତଦ୍ୱାରା ନିର୍ମିତ ଗ୍ଲୁକୋଜର ପରିମାଣକୁ ହ୍ରାସ କରିଥାଏ ଓ ତନ୍ତୁର ଗ୍ଲୁକୋଜ ଗ୍ରହଣକୁ ବୃଦ୍ଧି କରିଥାଏ | [୩]

୧୯୯୬ ମସିହାରେ ଇନସୁଲିନ ଲିସପ୍ରୋ ପ୍ରଥମେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।[୪] [୭] [୮] | ଏଥିରେ ମାନବ ଇନସୁଲିନର ଏକ ଆମିନୋ ଏସିଡ ବଦଳେଇ ଦେବା ପରେ ଉତ୍ପାଦନ କରାଯାଏ । [୯] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୧୯ ସୁଦ୍ଧା 100 ୟୁନିଟ୍ ପିଛା ୧.୮୯ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହେଉଛି | [୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୩୦ ଡଲାର ଅଟେ | [୧୦] ୨୦୧୭ ମସିହାରେ, ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୨୪ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଛଅ ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା | [୧୧] [୧୨]

ଆଧାର[ସମ୍ପାଦନା]

  1. ↑ ୧.୦ ୧.୧ "Insulin lispro Use During Pregnancy". Drugs.com. 7 October 2019. Archived from the original on 19 September 2020. Retrieved 23 February 2020.
  2. ↑ "Humalog 100 units/ml, solution for injection in vial - Summary of Product Characteristics (SmPC)". (emc). 30 January 2020. Archived from the original on 23 February 2020. Retrieved 23 February 2020.
  3. ↑ ୩.୦ ୩.୧ ୩.୨ ୩.୩ ୩.୪ ୩.୫ ୩.୬ ୩.୭ "Insulin Lispro Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  4. ↑ ୪.୦ ୪.୧ ୪.୨ "Insulin Lispro Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  5. ↑ ୫.୦ ୫.୧ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 698. ISBN 9780857113382.
  6. ↑ "Insulin lispro Pregnancy and Breastfeeding Warnings". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 19 September 2020. Retrieved 3 March 2019.
  7. ↑ "Humalog- insulin lispro injection, solution Humalog Kwikpen- insulin lispro injection, solution Humalog Junior Kwikpen- insulin lispro injection, solution Humalog Tempo Pen- insulin lispro injection, solution". DailyMed. 25 November 2019. Archived from the original on 24 September 2019. Retrieved 23 February 2020.
  8. ↑ "Humalog approval" (PDF). U.S. Food and Drug Administration (FDA). 14 June 1996. Archived from the original (PDF) on 24 February 2020. Retrieved 23 February 2020.
  9. ↑ Koivisto VA (June 1998). "The human insulin analogue insulin lispro". Annals of Medicine. 30 (3): 260–6. doi:10.3109/07853899809005853. PMID 9677011.
  10. ↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
  11. ↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  12. ↑ "Insulin Lispro - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.
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