ଆର୍ସେନିକ ଟ୍ରାଇଅକ୍ସାଇଡ

Arsenic trioxide
	Arsenic trioxide As3+ O2−
Clinical data
Trade names	Trisenox, others
Synonyms	Arsenic(III) oxide,; Arsenic sesquioxide,; Arseneous oxide,; Ratsbane,; Arseneous anhydride,; White arsenic,; Aqua Tofani
AHFS/Drugs.com	monograph
MedlinePlus	a608017
data	US DailyMed: Arsenic_trioxide;
Pregnancy; category	AU: X (High risk) ; ;
Routes of; administration	Intravenous
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Protein binding	75%
Excretion	Urine
Identifiers
	IUPAC name Diarsenic trioxide;
ECHA InfoCard	100.014.075
Chemical and physical data
Formula	As2O3
Molar mass	୧୯୭.୮୪ g·mol−1
3D model (JSmol)	Interactive image;
Density	3.74 g/cm3
Melting point	312.2 °C (594.0 °F)
Boiling point	465 °C (869 °F)
Solubility in water	20 g/L (25 °C); see text mg/mL (20 °C)
	SMILES O1[As]3O[As]2O[As](O3)O[As]1O2;
	InChI InChI=1S/As2O3/c3-1-4-2(3)5-1; ; Key:GOLCXWYRSKYTSP-UHFFFAOYSA-N;

ଆର୍ସେନିକ ଟ୍ରାଇଅକ୍ସାଇଡ ଏକ ଅଣ‌ଜୈବିକ ଯୌଗିକ ପଦାର୍ଥ ଓ ଔଷଧ ଯାହା ଟ୍ରାଇସେନ‌କ୍ସ ନାମରେ ବିକ୍ରୟ ହୁଏ ।^[୨] ଏକ ଶିଳ୍ପ ରାସାୟନିକ ଭାବରେ କାଠ ସୁରକ୍ଷାକାରୀ, କୀଟନାଶକ ଓ କାଚ ଜିନିଷ ତିଆରିରେ ବ୍ୟବ‌ହୃତ ହୁଏ । ^[୩] ଆକ୍ୟୁଟ ପ୍ରୋମାୟେଲୋସାଇଟିକ ଲିଉକେମିଆ କର୍କଟ ରୋଗର ଚିକିତ୍ସାରେ ବ୍ୟବ‌ହାର କରାଯାଏ | ^[୪] ଏହି ବ୍ୟବହାର ପାଇଁ ଏହା ଶିରାଭ୍ୟନ୍ତର ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ । | ^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ତରଳ ଝାଡ଼ା, ଫୁଲା, ଅଣନିଶ୍ୱାସ, ଏବଂ ମୁଣ୍ଡ ବିନ୍ଧା ହୋଇପାରେ | ^[୪] ଗୁରୁତର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରେଟିନୋଇକ ସିଣ୍ଡ୍ରୋମ ଏବଂ ହୃତ୍‌ପିଣ୍ଡ ସମସ୍ୟା ହୋଇପାରେ | ^[୪] ଗର୍ଭାବସ୍ଥାରେ କିମ୍ବା ସ୍ତନ୍ୟପାନ କରାଇବା ସମୟରେ ଏହା ଦେଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ | ^[୫] ^[୬] ଆର୍ସେନିକ ଟ୍ରାଇଅକ୍ସାଇଡର ରାସାୟନିକ ଫର୍ମୁଲା ଇଂରାଜୀରେ As₂O₃ କୁହାଯାଏ ।^[୭] କର୍କଟ ରୋଗରେ ଏହାର କାମ ପ୍ରଣାଳୀ ସଂପୂର୍ଣ୍ଣ ସ୍ପଷ୍ଟ ନୁହେଁ | ^[୪]

ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୦୦ମସିହାରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ଆର୍ସେନିକ୍ ଟ୍ରାଇକ୍ସାଇଡ ବ୍ୟବ‌ହାର ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୪] ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନ ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ତାଲିକାରେ ଏହାର ନାମ ଅଛି ।^[୮] ଏହା ବର୍ଷକୁ ପ୍ରାୟ ୫୦,୦୦୦ ଟନ ଉତ୍ପାଦିତ ହୁଏ | ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୧୮ ମସିହା ସୁଦ୍ଧା ଏକ ଡୋଜ ପିଛା ଏହାର ଖର୍ଚ୍ଚ ପ୍ରାୟ ୨୯୨ ପାଉଣ୍ଡ । ^[୯] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣ ୨୦୧୯ ସୁଦ୍ଧା ପ୍ରାୟ ୫୦୮ ଆମେରିକୀୟ ଡଲାର ଅଟେ। ^[୧୦] ଏହାର ବିଷାକ୍ତତା ହେତୁ ଅନେକ ଦେଶରେ ଏହାର ଉତ୍ପାଦନ ଏବଂ ବିକ୍ରୟ ପାଇଁ ନିୟମ କାନୁନ ରହିଛି | ^[୧୧]

ଆଧାର

↑ Shakhashiri, B. Z. "Chemical of the Week: Arsenic". University of Wisconsin-Madison Chemistry Dept. Archived from the original on 2008-08-02. Retrieved 2008-08-03.
↑ "Arsenic Trioxide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 15 November 2019.
↑ Landner, Lars (2012). Chemicals in the Aquatic Environment: Advanced Hazard Assessment (in ଇଂରାଜୀ). Springer Science & Business Media. p. 259. ISBN 9783642613340.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Arsenic Trioxide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 15 November 2019.
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 907. ISBN 9780857113382.
↑ "Arsenic trioxide (Trisenox) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Retrieved 16 November 2019.
↑ Sun, Hongzhe (2010). Biological Chemistry of Arsenic, Antimony and Bismuth. John Wiley & Sons. p. 295. ISBN 9780470976227.
↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 907. ISBN 9780857113382.
↑ "Arsenic trioxide Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 16 November 2019.
↑ Consolidated List of Products Whose Consumption And/or Sale Have Been Banned, Withdrawn, Severely Restricted Or Not Approved by Governments: Chemicals (in ଇଂରାଜୀ). United Nations Publications. 2009. p. 24. ISBN 9789211302196.

[1] Shakhashiri, B. Z. "Chemical of the Week: Arsenic". University of Wisconsin-Madison Chemistry Dept. Archived from the original on 2008-08-02. Retrieved 2008-08-03.

[AHFS2019-2] "Arsenic Trioxide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 15 November 2019.

[Land2012-3] Landner, Lars (2012). Chemicals in the Aquatic Environment: Advanced Hazard Assessment (in ଇଂରାଜୀ). Springer Science & Business Media. p. 259. ISBN 9783642613340.

[autogen2-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Arsenic Trioxide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 15 November 2019.

[BNF76-5] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 907. ISBN 9780857113382.

[6] "Arsenic trioxide (Trisenox) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Retrieved 16 November 2019.

[7] Sun, Hongzhe (2010). Biological Chemistry of Arsenic, Antimony and Bismuth. John Wiley & Sons. p. 295. ISBN 9780470976227.

[WHO21st-8] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[autogen1-9] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 907. ISBN 9780857113382.

[Price2019-10] "Arsenic trioxide Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 16 November 2019.

[11] Consolidated List of Products Whose Consumption And/or Sale Have Been Banned, Withdrawn, Severely Restricted Or Not Approved by Governments: Chemicals (in ଇଂରାଜୀ). United Nations Publications. 2009. p. 24. ISBN 9789211302196.

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