ଆମୋଡିଆକୁଇନ

ଆମୋଡିଆକୁଇନ
Clinical data
Trade names	Amdaquine, Amobin, others
AHFS/Drugs.com	International Drug Names
ATC code	P01BA06 (WHO) ;
Identifiers
	IUPAC name 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol;
CAS Number	86-42-0 ;
PubChem CID	2165;
DrugBank	DB00613 ;
ChemSpider	2080 ;
UNII	220236ED28;
KEGG	D02922 ;
ChEBI	CHEBI:2674 ;
ChEMBL	CHEMBL682 ;
ECHA InfoCard	100.001.518
Chemical and physical data
Formula	C20H22ClN3O
Molar mass	355.861 g/mol
3D model (JSmol)	Interactive image;
	SMILES Clc1cc2nccc(c2cc1)Nc3cc(c(O)cc3)CN(CC)CC;
	InChI InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23) ; Key:OVCDSSHSILBFBN-UHFFFAOYSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Amodiaquine

ଆମୋଡିଆକୁଇନ ବା ଏକ୍ୟୁଡି (ଇଂରାଜୀ ଭାଷାରେ Amodiaquine ବା ADQ) ଔଷଧ ସମସ୍ତ ମ୍ୟାଲେରିଆ ରୋଗର ଚିକିତ୍ସା ନିମନ୍ତେ ଦିଆଯାଏ କେବଳ ଜଟିଳ ପ୍ଲାଜମୋଡିଅମ ଫାଲସିପ୍ୟାରମ ବ୍ୟତୀତ ।^[୨]^[୩] ପ୍ରତିରୋଧ ସଙ୍କଟ ନ ଆସିବା ନିମନ୍ତେ ଏହା ଆର୍ଟେସୁନେଟ (artesunate) ସ‌ହିତ ଦିଆଯାଏ । ଏହାର ସାଂଘାତିକ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ଯୋଗୁ ବିରଳ ହେଲେ ମଧ୍ୟ ସାଧାରଣତଃ ଦେବାକୁ ସୁପାରିସ କରାଯାଏ ନାହିଁ ।^[୨]

ଏହାର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ସାଧାରଣରୁ ମଧ୍ୟମ ଧରଣର ହୁଏ ଓ କ୍ଲୋରୋକୁଇନ (chloroquine) ଅନୁରୂପ ହୁଏ ।^[୩] ଯକୃତ ସମସ୍ୟା (liver problems) ଓ ଆଗ୍ରାନୁଲୋସାଇଟୋସିସ (low blood cell levels) ଦେଖାଯାଇପାରେ । ଔଷଧ ଅଧିକ ହୋଇଗଲେ ମୁଣ୍ଡବଥା, ଦୃଷ୍ଟି ସମସ୍ୟା, ବାତ (seizures) ଓ ହୃଦ୍‌ରୋଧ ହୋଇପାରେ ।^[୨] ଅଧିକ ଅନୁଶୀଳନ ହୋଇନଥିଲେ ମଧ୍ୟ ଗର୍ଭାବସ୍ଥାରେ ଏହା ନିରାପଦ ଜଣାଯାଏ ।^[୪]ଏହା ୪-ଆମିନୋକୁଇନୋଲିନ (4-aminoquinoline) ଶ୍ରେଣୀର ଔଷଧ ଯାହାର ଅନ୍ୟ ଏକ ଔଷଧର ନାମ କ୍ଲୋରୋକୁଇନ ।^[୨]

ସନ ୧୯୪୮ରେ ପ୍ରଥମେ ଆମୋଡିଆକୁଇନ ପ୍ରସ୍ତୁତ କରାଯାଇଥିଲା ।^[୫] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୬] ସନ ୨୦୧୪ରେ ଏହାର ହୋଲସେଲ ମୁଲ୍ୟ ୦.୦୧ ଆମେରିକୀୟ ଡଲାର ଥିଲା ।^[୭] ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଉପଲବ୍ଧ ନୁହେଁ,^[୮] କିନ୍ତୁ ଆଫ୍ରିକାରେ ବ‌ହୁଳ ଭାବରେ ଉପଲବ୍ଧ ।^[୨]^[୯]

ଆଧାର

↑ "Amodiaquine". drugs.com. Retrieved 27 November 2016.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ Nair, A; Abrahamsson, B; Barends, DM; Groot, DW; Kopp, S; Polli, JE; Shah, VP; Dressman, JB (December 2012). "Biowaiver monographs for immediate release solid oral dosage forms: amodiaquine hydrochloride". Journal of pharmaceutical sciences. 101 (12): 4390–401. PMID 22949374.
↑ ^୩.୦ ^୩.୧ Olliaro, P; Mussano, P (2003). "Amodiaquine for treating malaria". The Cochrane database of systematic reviews (2): CD000016. PMID 12804382.
↑ Tagbor, HK; Chandramohan, D; Greenwood, B (November 2007). "The safety of amodiaquine use in pregnant women". Expert opinion on drug safety. 6 (6): 631–5. PMID 17967151.
↑ Profiles of Drug Substances, Excipients and Related Methodology (in ଇଂରାଜୀ). Academic Press. 1992. p. 45. ISBN 9780080861166.
↑ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
↑ "Amodiaquine". International Drug Price Indicator Guide. Retrieved 4 December 2015.^{[permanent dead link]}
↑ "Amodiaquine". Livertox. Retrieved 27 November 2016.
↑ Centers for Disease Control, (CDC). (12 April 1985). "Revised recommendations for preventing malaria in travelers to areas with chloroquine-resistant Plasmodium falciparum". MMWR. Morbidity and mortality weekly report. 34 (14): 185–90, 195. PMID 3156271.

[1] "Amodiaquine". drugs.com. Retrieved 27 November 2016.

[Na2012-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ Nair, A; Abrahamsson, B; Barends, DM; Groot, DW; Kopp, S; Polli, JE; Shah, VP; Dressman, JB (December 2012). "Biowaiver monographs for immediate release solid oral dosage forms: amodiaquine hydrochloride". Journal of pharmaceutical sciences. 101 (12): 4390–401. PMID 22949374.

[Co2003-3] ୩.୦ ^୩.୧ Olliaro, P; Mussano, P (2003). "Amodiaquine for treating malaria". The Cochrane database of systematic reviews (2): CD000016. PMID 12804382.

[4] Tagbor, HK; Chandramohan, D; Greenwood, B (November 2007). "The safety of amodiaquine use in pregnant women". Expert opinion on drug safety. 6 (6): 631–5. PMID 17967151.

[5] Profiles of Drug Substances, Excipients and Related Methodology (in ଇଂରାଜୀ). Academic Press. 1992. p. 45. ISBN 9780080861166.

[6] "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[7] "Amodiaquine". International Drug Price Indicator Guide. Retrieved 4 December 2015.^{[permanent dead link]}

[8] "Amodiaquine". Livertox. Retrieved 27 November 2016.

[CDC1985-9] Centers for Disease Control, (CDC). (12 April 1985). "Revised recommendations for preventing malaria in travelers to areas with chloroquine-resistant Plasmodium falciparum". MMWR. Morbidity and mortality weekly report. 34 (14): 185–90, 195. PMID 3156271.

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