ଆଜେଲାଷ୍ଟାଇନ

ଆଜେଲାଷ୍ଟାଇନ
Clinical data
Trade names	Astelin, Optivar, Allergodil, others.
AHFS/Drugs.com	monograph
MedlinePlus	a603009
data	US DailyMed: Azelastine;
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	Eye drops, nasal spray, by mouth
Legal status
Legal status	AU: S2 (Pharmacy only) ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	40% (intranasal)
Elimination half-life	22 hours
Identifiers
	IUPAC name (RS)-4-[(4-Chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one;
ECHA InfoCard	100.133.278
Chemical and physical data
Formula	C22H24ClN3O
Molar mass	୩୮୧.୯0 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1)CC\3=N\N(C(=O)c2ccccc2/3)C4CCCN(C)CC4;
	InChI InChI=1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3 ; Key:MBUVEWMHONZEQD-UHFFFAOYSA-N ;
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ଆଜେଲାଷ୍ଟାଇନ, ଏକ ବିକ୍ରୟ ନାମ ଅପ୍ଟିଭାର୍, ଏକ ଔଷଧ ଯାହା ମୁଖ୍ୟତଃ ଆଲର୍ଜି ରାଇନାଇଟିସ୍ (ହେ ଜ୍ୱର)ର ଚିକିତ୍ସା ପାଇଁ ନାକ ସ୍ପ୍ରେ ଭାବରେ ବ୍ୟବହୃତ ହୁଏ ଏବଂ ଆଲର୍ଜି କଞ୍ଜକ୍ଟିଭାଇଟିସ୍ ପାଇଁ ଆଖିରେ ବୁନ୍ଦା ପକାଯାଏ | ^[୨] ^[୩] ଆଜ୍‌ମା ଏବଂ ଚର୍ମ ରାସ ନିମନ୍ତେ ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୪] ଆଖିରେ ବ୍ୟବହୃତ ହେଉଥିବା ସମୟରେ କିଛି ମିନିଟ ମଧ୍ୟରେ ଏବଂ ନାକରେ ବ୍ୟବହୃତ ହେଉଥିବା ବେଳେ ଏକ ଘଣ୍ଟା ମଧ୍ୟରେ ଏହାର ପ୍ରଭାବ ଆରମ୍ଭ ହୁଏ | ^[୫] ପ୍ରଭାବ ୧୨ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ | ^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା, ନିଦ୍ରାଳୁ, ସ୍ୱାଦ ପରିବର୍ତ୍ତନ ଏବଂ ଗଳା ଯନ୍ତ୍ରଣା ହୋଇପାରେ | ^[୩] ଗର୍ଭାବସ୍ଥାରେ କିମ୍ବା ସ୍ତନ୍ୟପାନ ସମୟରେ ବ୍ୟବହାର ନିରାପଦ କି ନୁହେଁ ତାହା ଅସ୍ପଷ୍ଟ ରହିଛି। ^[୬] ଏହା ଦ୍ୱିତୀୟ ପିଢ଼ୀର ଏକ ଆଣ୍ଟିହିଷ୍ଟାମିନ ଏବଂ ହିଷ୍ଟାମିନ ସ‌ହିତ ଆହୁରି ଅନେକ ପ୍ରଦାହ ମେଡିଏଟରକୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷନ ହୁଏ ।^[୪] ^[୫]

ଆଜେଲାଷ୍ଟାଇନ ୧୯୭୧ ମସିହାର ପେଟେଣ୍ଟ୍ ହୋଇଥିଲା ଏବଂ ୧୯୮୬ ମସିହାରେ ଡାକ୍ତରୀ ବ୍ୟବହାରରେ ଆସିଥିଲା |^[୭] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ୨୨ ମିଲିଲିଟର ବୋତଲ ୨୦୧୯ ସୁଦ୍ଧା ମୂଲ୍ୟ ୧୦.୫୦ ପାଉଣ୍ଡ ଥିଲା । ^[୨] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୮.୪୦ ଆମେରିକୀୟ ଡଲାର ଅଟେ । ^[୮] ୨୦୧୭ ମସିହାରେ ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୯୭ତମ ସାଧାରଣତ ପ୍ରେସକ୍ରିପସନ୍ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଏକ ମିଲିୟନରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା | ^[୯] ^[୧୦]

ଆଧାର

↑ Drugs.com Drugs.com international listings for azelastine Archived 2016-06-05 at the Wayback Machine. Page accessed June 28, 2015
↑ ^୨.୦ ^୨.୧ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1169. ISBN 9780857113382.
↑ ^୩.୦ ^୩.୧ "Azelastine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 2019-03-26. Retrieved 2019-03-26.
↑ ^୪.୦ ^୪.୧ Aronson, Jeffrey K. (2015). Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (in ଇଂରାଜୀ). Elsevier. p. 782. ISBN 9780444537164. Archived from the original on 2019-03-27. Retrieved 2019-03-26.
↑ ^୫.୦ ^୫.୧ ^୫.୨ "Azelastine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 2019-03-26. Retrieved 2019-03-26.
↑ "Azelastine ophthalmic (Optivar) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 March 2019. Retrieved 26 March 2019.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 548. ISBN 9783527607495. Archived from the original on 2020-03-06. Retrieved 2019-03-03.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
↑ "Azelastine Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 13 April 2020. Retrieved 11 April 2020.

[Names-1] Drugs.com Drugs.com international listings for azelastine Archived 2016-06-05 at the Wayback Machine. Page accessed June 28, 2015

[BNF76-2] ୨.୦ ^୨.୧ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1169. ISBN 9780857113382.

[AHFS2019-3] ୩.୦ ^୩.୧ "Azelastine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 2019-03-26. Retrieved 2019-03-26.

[Aron2015-4] ୪.୦ ^୪.୧ Aronson, Jeffrey K. (2015). Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (in ଇଂରାଜୀ). Elsevier. p. 782. ISBN 9780444537164. Archived from the original on 2019-03-27. Retrieved 2019-03-26.

[autogen4-5] ୫.୦ ^୫.୧ ^୫.୨ "Azelastine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 2019-03-26. Retrieved 2019-03-26.

[6] "Azelastine ophthalmic (Optivar) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 March 2019. Retrieved 26 March 2019.

[Fis2006-7] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 548. ISBN 9783527607495. Archived from the original on 2020-03-06. Retrieved 2019-03-03.

[NADAC2019-8] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[ref-9] "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.

[ref1-10] "Azelastine Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 13 April 2020. Retrieved 11 April 2020.

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