ଅର୍ଫେନାଡ୍ରାଇନ

ଅର୍ଫେନାଡ୍ରାଇନ
Clinical data
Trade names	Generic; many brands
Synonyms	Orphenadrine hydrochloride
AHFS/Drugs.com	monograph
MedlinePlus	a682162
Pregnancy; category	AU: B2 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth, intravenous, intramuscular
Legal status
Legal status	AU: S4 (Prescription only) ; CA: OTC ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	90%
Protein binding	95%
Metabolism	Liver demethylation
Elimination half-life	13-20 hours
Excretion	Kidney and biliary
Identifiers
	IUPAC name (RS)-N,N-Dimethyl-2-[(2-methylphenyl)-phenyl-methoxy]-ethanamine;
ECHA InfoCard	100.001.372
Chemical and physical data
Formula	C18H23NO
Molar mass	୨୬୯.୩୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O(CCN(C)C)C(c1ccccc1)c2ccccc2C;
	InChI InChI=1S/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16/h4-12,18H,13-14H2,1-3H3 ; Key:QVYRGXJJSLMXQH-UHFFFAOYSA-N ;
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ଅର୍ଫେନାଡ୍ରାଇନ, ଏକ ଔଷଧ ଯାହାକି ମାଂସପେଶୀ ଯନ୍ତ୍ରଣା ସ‌ହିତ କଟି ଯନ୍ତ୍ରଣା ଏବଂ ପାର୍କିନସୋନିଜିମ୍ ରୋଗର ଚିକିତ୍ସା କରିବା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୩] ^[୪] ଏହା ପାଟିରେ କିମ୍ବା ଇଞ୍ଜେକ୍ସନଦ୍ୱାରା ଦିଆଯାଏ | ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶୁଖିଲା ପାଟି, ଦ୍ରୁତ ହୃଦସ୍ପନ୍ଦନ, ମୂତ୍ର ଧାରଣ, ଅସ୍ପଷ୍ଟ ଦୃଷ୍ଟିଶକ୍ତି, ଅଇ, ନିଦ୍ରାଳୁ ଏବଂ କୋଷ୍ଠକାଠିନ୍ୟ ହୋଇପାରେ ।^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲାକ୍‌ସିସ ହୋଇପାରେ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ।^[୩] ଏହା ଏକ ଆଣ୍ଟିକୋଲିନରଜିକ୍ ଏବଂ ଆଣ୍ଟିହିଷ୍ଟାମାଇନ୍ ଶ୍ରେଣୀର ଔଷଧ ।^[୩] ଏହା କିପରି କାର୍ଯ୍ୟ କରେ ତାହା ସମ୍ପୂର୍ଣ୍ଣ ସ୍ପଷ୍ଟ ନୁହେଁ ।^[୩]

୧୯୪୦ ଦଶକରେ ଅର୍ଫେନାଡ୍ରାଇନ ବିକଶିତ ହୋଇଥିଲା ଏବଂ ୧୯୫୭ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ^[୩] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ୫୦ ମିଗ୍ରାର ୩୦ମାତ୍ରାର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ £୫୬ ଅଟେ ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ୨୦ ଡଲାରରୁ କମ୍ ଅଟେ ।^[୬]

ଆଧାର

↑ "Orphenadrine". Drugs.com international listings. Archived from the original on 5 March 2016. Retrieved 5 February 2016.
↑ Labout JJ, Thijssen C, Keijser GG, Hespe W (1982). "Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man". European Journal of Clinical Pharmacology. 21 (4): 343–50. doi:10.1007/BF00637624. PMID 7056281. S2CID 24631265. Archived from the original on 2021-10-26. Retrieved 2021-10-08.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ ^୩.୭ "Orphenadrine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 July 2021. Retrieved 9 November 2021.
↑ ^୪.୦ ^୪.୧ ^୪.୨ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 431. ISBN 978-0857114105.
↑ Deer, Timothy R.; Pope, Jason E.; Lamer, Tim J.; Provenzano, David (1 August 2019). Deer's Treatment of Pain: An Illustrated Guide for Practitioners (in ଇଂରାଜୀ). Springer. p. 185. ISBN 978-3-030-12281-2. Archived from the original on 9 November 2021. Retrieved 9 November 2021.
↑ "Orphenadrine Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 July 2021. Retrieved 9 November 2021.

[Drugs.com-1] "Orphenadrine". Drugs.com international listings. Archived from the original on 5 March 2016. Retrieved 5 February 2016.

[2] Labout JJ, Thijssen C, Keijser GG, Hespe W (1982). "Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man". European Journal of Clinical Pharmacology. 21 (4): 343–50. doi:10.1007/BF00637624. PMID 7056281. S2CID 24631265. Archived from the original on 2021-10-26. Retrieved 2021-10-08.

[AHFS2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ ^୩.୭ "Orphenadrine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 July 2021. Retrieved 9 November 2021.

[BNF81-4] ୪.୦ ^୪.୧ ^୪.୨ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 431. ISBN 978-0857114105.

[5] Deer, Timothy R.; Pope, Jason E.; Lamer, Tim J.; Provenzano, David (1 August 2019). Deer's Treatment of Pain: An Illustrated Guide for Practitioners (in ଇଂରାଜୀ). Springer. p. 185. ISBN 978-3-030-12281-2. Archived from the original on 9 November 2021. Retrieved 9 November 2021.

[6] "Orphenadrine Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 July 2021. Retrieved 9 November 2021.

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