ଅକ୍ସାଜେପାମ

ଅକ୍ସାଜେପାମ
Clinical data
Trade names	Serax, Alepam, others
AHFS/Drugs.com	monograph
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: Schedule IV ; DE: Rx-only/Anlage III ; US: Schedule IV ;
Pharmacokinetic data
Bioavailability	92.8%
Metabolism	Liver (glucuronidation)
Elimination half-life	6–9 h
Excretion	Kidney
Identifiers
	IUPAC name 7-Chloro-3-hydroxy-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one;
ECHA InfoCard	100.009.161
Chemical and physical data
Formula	C15H11ClN2O2
Molar mass	୨୮୬.୭୧ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	205 to 206 °C (401 to 403 °F)
	SMILES OC1N=C(C2=C(NC1=O)C=CC(Cl)=C2)C3=CC=CC=C3;
	InChI InChI=1S/C15H11ClN2O2/c16-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)18-15(20)14(19)17-12/h1-8,15,18,20H ; Key:IMAUTQQURLXUGJ-UHFFFAOYSA-N ;
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ଅକ୍ସାଜେପାମ ହେଉଛି ଏକ ପ୍ରକାର ବେଞ୍ଜୋଡାଏଜେପିନ ଔଷଧ ଯାହା ଉଦ୍‌ବେଗ, ଶୋଇବାରେ ଅସୁବିଧା ଏବଂ ମଦ୍ୟପାନ ପ୍ରତ୍ୟାହାର ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୫] ^[୬] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୬] ଏହାର ପ୍ରଭାବ ଅପେକ୍ଷାକୃତ ଧୀରେ ଆରମ୍ଭ ହୁଏ କିନ୍ତୁ ଦୀର୍ଘସ୍ଥାୟୀ ପ୍ରଭାବ ରହେ ।^[୭]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ, ମୁଣ୍ଡ ବୁଲାଇବା ଏବଂ ମୁଣ୍ଡବିନ୍ଧା ହୋଇପାରେ ।^[୬] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅପବ୍ୟବହାର, ଉତ୍ତେଜନା, ସ୍ମୃତି ଶକ୍ତି ହ୍ରାସ, ଆତ୍ମହତ୍ୟା ପ୍ରବଣତା ଏବଂ ଅସ୍ପଷ୍ଟ କଥାବାର୍ତ୍ତା ହୋଇପାରେ ।^[୫] ପ୍ରାରମ୍ଭିକ ଗର୍ଭଧାରଣ ସମୟରେ ବ୍ୟବହାର କରିବାକୁ ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୬] ଓପିଓଏଡ୍ ସହିତ ବ୍ୟବହାର କରିବାକୁ ସାଧାରଣତଃ ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୬] ଏହା ଜିଏବିଏ (GABA) ନ୍ୟୁରୋଟ୍ରାନ୍ସମିଟର ମାଧ୍ୟମରେ କାମ କରେ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ ।^[୬]

ଅକ୍ସାଜେପାମ ୧୯୬୨ ମସିହାରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୬୪ରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୮] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ୧୫ମିଗ୍ରାର ୨୮ଟି ବଟିକାର ମୂଲ୍ୟ ୨୦୨୧ ମସିହାରେ ପ୍ରାୟ £୬ ଥିଲା ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣ ଔଷଧର ମୂଲ୍ୟ ପ୍ରାୟ ୩୦ ଡଲାର ଅଟେ। ।^[୯]

ଆଧାର

↑ "Encadré 1. Anxiolytiques à demi-vie courte (< 20 heures) et sans métabolite actif par ordre alphabétique de DCI" (PDF). Archived (PDF) from the original on 2021-06-28. Retrieved 2021-09-06.
↑ Sonne, J; Loft, S; Døssing, M; Vollmer-Larsen, A; Olesen, KL; Victor, M; Andreasen, F; Andreasen, PB (1988). "Bioavailability and pharmacokinetics of oxazepam". European Journal of Clinical Pharmacology. 35 (4): 385–9. doi:10.1007/bf00561369. PMID 3197746. S2CID 31007311.
↑ Sonne, J; Boesgaard, S; Poulsen, H E; Loft, S; Hansen, J M; Døssing, M; Andreasen, F (November 1990). "Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism". British Journal of Clinical Pharmacology. 30 (5): 737–742. doi:10.1111/j.1365-2125.1990.tb03844.x. PMC 1368175. PMID 2271373.
↑ CID 4616 from PubChem
1 2 3 4 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. X. ISBN 978-0857114105.
1 2 3 4 5 6 "Oxazepam Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 10 February 2018. Retrieved 10 November 2021.
↑ Fitzgerald, Margaret A. (14 March 2017). Nurse Practitioner Certification Examination and Practice Preparation (in ଇଂରାଜୀ). F.A. Davis. p. 346. ISBN 978-0-8036-6917-8. Archived from the original on 10 November 2021. Retrieved 10 November 2021.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 536. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2021-09-06.
↑ "Oxazepam Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 April 2021. Retrieved 10 November 2021.

[1] "Encadré 1. Anxiolytiques à demi-vie courte (< 20 heures) et sans métabolite actif par ordre alphabétique de DCI" (PDF). Archived (PDF) from the original on 2021-06-28. Retrieved 2021-09-06.

[pmid3197746-2] Sonne, J; Loft, S; Døssing, M; Vollmer-Larsen, A; Olesen, KL; Victor, M; Andreasen, F; Andreasen, PB (1988). "Bioavailability and pharmacokinetics of oxazepam". European Journal of Clinical Pharmacology. 35 (4): 385–9. doi:10.1007/bf00561369. PMID 3197746. S2CID 31007311.

[3] Sonne, J; Boesgaard, S; Poulsen, H E; Loft, S; Hansen, J M; Døssing, M; Andreasen, F (November 1990). "Pharmacokinetics and pharmacodynamics of oxazepam and metabolism of paracetamol in severe hypothyroidism". British Journal of Clinical Pharmacology. 30 (5): 737–742. doi:10.1111/j.1365-2125.1990.tb03844.x. PMC 1368175. PMID 2271373.

[4] CID 4616 from PubChem

[BNF81-5] 1 2 3 4 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. X. ISBN 978-0857114105.

[AHFS2021-6] 1 2 3 4 5 6 "Oxazepam Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 10 February 2018. Retrieved 10 November 2021.

[7] Fitzgerald, Margaret A. (14 March 2017). Nurse Practitioner Certification Examination and Practice Preparation (in ଇଂରାଜୀ). F.A. Davis. p. 346. ISBN 978-0-8036-6917-8. Archived from the original on 10 November 2021. Retrieved 10 November 2021.

[Fis2006-8] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 536. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2021-09-06.

[9] "Oxazepam Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 April 2021. Retrieved 10 November 2021.

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