ସେଫ୍ଟାରୋଲିନ ଫୋସାମିଲ

ସେଫ୍ଟାରୋଲିନ ଫୋସାମିଲ
Clinical data
Pronunciation	/sɛfˈtæroʊliːn/
Trade names	Teflaro, Zinforo
Synonyms	Ceftaroline, PPI 0903, TAK-599
AHFS/Drugs.com	monograph
MedlinePlus	a611014
data	EU EMA: yes; US DailyMed: Ceftaroline_fosamil;
Pregnancy; category	AU: B1 ; ;
Routes of; administration	Intravenous
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Protein binding	20%
Elimination half-life	2.5 hours
Excretion	Urine (88%), faeces (6%)
Identifiers
	IUPAC name (6R,7R)-7-[(2Z)-2-ethoxyimino-2-[5-(phosphonoamino)-1,2,4-thiadiazol-3-yl]acetyl]amino]-3-[4-(1-methylpyridin-1-ium-4-yl)-1,3-thiazol-2-yl]sulfanyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;
Chemical and physical data
Formula	C22H21N8O8PS4
Molar mass	୬୮୪.୬୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C4N3/C(=C(/Sc2nc(c1cc[n+](cc1)C)cs2)CS[C@@H]3[C@@H]4NC(=O)C(=N\OCC)/c5nc(sn5)NP(=O)(O)O)C([O-])=O;
	InChI InChI=1S/C22H21N8O8PS4/c1-3-38-26-13(16-25-21(43-28-16)27-39(35,36)37)17(31)24-14-18(32)30-15(20(33)34)12(9-40-19(14)30)42-22-23-11(8-41-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H4-,24,25,27,28,31,33,34,35,36,37)/b26-13-/t14-,19-/m1/s1 ; Key:ZCCUWMICIWSJIX-NQJJCJBVSA-N ;
(verify)

ସେଫ୍ଟାରୋଲିନ ଫୋସାମିଲ, ବିକ୍ରୟ ନାମ ଟେଫଲାରୋ ଏବଂ ଜିନ୍ଫୋରୋ, ଏକ ଔଷଧ ଯାହା ଚର୍ମ ଓ କୋମଳ ତନ୍ତୁମାନଙ୍କର ସଂକ୍ରମଣ ଏବଂ ନିମୋନିଆର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବ‌ହୃତ ହୁଏ ।^[୨] ^[୧] ମେଥିଇସିଲିନ୍-ପ୍ରତିରୋଧୀ <i id="mwGA">ଷ୍ଟାଫିଲୋକୋକସ୍ ଅରିଅସ୍</i> (MRSA) ଥିବା ରୋଗୀଙ୍କ ଚିକିତ୍ସା ପାଇଁ ଏହା ବ୍ୟବହୃତ ହୁଏ । ^[୧] ^[୩] ଏହା ଏକ ଶିରାରେ ଇଞ୍ଜେକ୍ସନ ଆକାରରରେ ଦିଆଯାଏ । ^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ବାନ୍ତି, ରାଶ, ଜ୍ୱର ହୋଇପାରେ ।^[୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲକ୍ସିସ୍, କ୍ଲୋଷ୍ଟ୍ରିଡିଏଡସ୍ ଡିଫାଇସିଲ୍ ସଂକ୍ରମଣ ଏବଂ ଲୋହିଯ ରକ୍ତ କଣିକା ଭାଙ୍ଗିପାରେ । ^[୨] ଗର୍ଭଧାରଣରେ କୌଣସି କ୍ଷତି ହେବାର କୌଣସି ପ୍ରମାଣ ନାହିଁ, କିନ୍ତୁ ଏହିପରି ବ୍ୟବହାର ଭଲ ଭାବରେ ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ । ^[୫] ଏହା ଏକ ସେଫାଲୋସ୍ପୋରିନ୍ ଏବଂ ଜୀବାଣୁ କୋଷର କାନ୍ଥକୁ ଭାଙ୍ଗିଦେଇ କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ । ^[୨] ^[୧]

୨୦୧୦ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୧୨ରେ ୟୁରୋପରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ସେଫ୍ଟାରୋଲିନ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୩] ^[୧] ଏହାକୁ 2019ରେ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ତାଲିକାରୁ ବାହାର କରାଯାଇଥିଲା। ^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ୫ ଦିନର ଚିକିତ୍ସା ପାଇଁ ୨୦୨୧ରେ ପ୍ରାୟ ୩୭୫ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୁଏ । ^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ୨୨୦୦ ଡଲାର । ^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Zinforo EPAR". European Medicines Agency (EMA). Archived from the original on 12 July 2019. Retrieved 1 March 2020.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Teflaro- ceftaroline fosamil powder, for solution". DailyMed. 24 September 2019. Archived from the original on 18 January 2021. Retrieved 1 March 2020.
↑ ^୩.୦ ^୩.୧ "Ceftaroline Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 1 January 2022.
↑ ^୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 562. ISBN 978-0857114105.
↑ "Ceftaroline (Teflaro) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 November 2020. Retrieved 2 January 2022.
↑ World Health Organization (2019). Executive summary: the selection and use of essential medicines 2019: report of the 22nd WHO Expert Committee on the selection and use of essential medicines. Geneva: World Health Organization. hdl:10665/325773. WHO/MVP/EMP/IAU/2019.05. License: CC BY-NC-SA 3.0 IGO.
↑ "Teflaro Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 November 2020. Retrieved 2 January 2022.

[EPAR2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Zinforo EPAR". European Medicines Agency (EMA). Archived from the original on 12 July 2019. Retrieved 1 March 2020.

[PI2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Teflaro- ceftaroline fosamil powder, for solution". DailyMed. 24 September 2019. Archived from the original on 18 January 2021. Retrieved 1 March 2020.

[AHFS2021-3] ୩.୦ ^୩.୧ "Ceftaroline Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 1 January 2022.

[BNF81-4] ୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 562. ISBN 978-0857114105.

[5] "Ceftaroline (Teflaro) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 November 2020. Retrieved 2 January 2022.

[6] World Health Organization (2019). Executive summary: the selection and use of essential medicines 2019: report of the 22nd WHO Expert Committee on the selection and use of essential medicines. Geneva: World Health Organization. hdl:10665/325773. WHO/MVP/EMP/IAU/2019.05. License: CC BY-NC-SA 3.0 IGO.

[7] "Teflaro Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 November 2020. Retrieved 2 January 2022.

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