Jump to content

ମେଟାମିଜୋଲ

ଉଇକିପିଡ଼ିଆ‌ରୁ
ମେଟାମିଜୋଲ
Clinical data
Trade namesNovalgin, others[୨][୩]
SynonymsDipyrone (BAN UK, USAN US)
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • Not assigned; no evidence of teratogenicity in animals, use in 3rd trimester may cause heart problems[୧]
Routes of
administration		By mouth, IM, IV, rectal
Legal status
Legal status
  • Over-the-counter (some countries); prescription-only (others); withdrawn (others)
Pharmacokinetic data
Bioavailability100% (active metabolites)[୪]
Protein binding48–58% (active metabolites)[୪]
MetabolismLiver[୪]
Elimination half-life14 minutes (parent compound; parenteral);[୧] metabolites: 2–4 hours[୪]
ExcretionUrine (96%, IV; 85%, oral), faeces (4%, IV).[୧]
Identifiers
  • [(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino] methanesulfonic acid
ECHA InfoCard100.000.631 Edit this at Wikidata
Chemical and physical data
FormulaC13H17N3O4S
Molar mass୩୧୧.୩୬ g·mol−1
3D model (JSmol)
  • c1ccccc1N2N(C)C(C)=C(C2=O)N(C)CS(=O)(=O)O
  • InChI=1S/C13H17N3O4S/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11/h4-8H,9H2,1-3H3,(H,18,19,20) ☒N
  • Key:LVWZTYCIRDMTEY-UHFFFAOYSA-N ☒N
  (verify)

ମେଟାମିଜୋଲ, ଯାହା ଡିପିରୋନ୍ ଭାବରେ ମଧ୍ୟ ଜଣାଶୁଣା, ଏକ ଯନ୍ତ୍ରଣା ନିବାରକ, ସ୍ପାଜମ ମୁକ୍ତିକାରୀ ଏବଂ ଜ୍ୱର ହ୍ରାସକାରୀ ଔଷଧ । [୫] ଯେତେବେଳେ ଅନ୍ୟ ଔଷଧ ପ୍ରଭାବଶାଳୀ ନଥାଏ ସେତେବେଳେ ଏହା ବ୍ୟବହୃତ ହୋଇପାରେ । [୫] ଆରମ୍ଭ ଶୀଘ୍ର ହୁଏ ଏବଂ ପ୍ରଭାବ ୮ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ । [୬] ଏହା ପାଟିରେ, ମଳଦ୍ୱାରରେ କିମ୍ବା ଇଞ୍ଜେକ୍ସନ‌ଦ୍ୱାରା ଦିଆଯାଇପାରେ | [୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ ଭାବ, ପେଟ ଅସ୍ୱାଭାବିକତା ଏବଂ ଅଇ ଲାଗେ । [୭] ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୋର ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା, ଆନାଫାଇଲକ୍ସିସ୍ ଏବଂ ନିମ୍ନ ଶ୍ୱେତ ରକ୍ତ କଣିକା ଅନ୍ତର୍ଭୁକ୍ତ | [୮] ପ୍ରାରମ୍ଭିକ ଗର୍ଭାବସ୍ଥାରେ ଏହା ଅପେକ୍ଷାକୃତ ନିରାପଦ ଦେଖାଯାଉଥିବାବେଳେ ପରବର୍ତ୍ତୀ ଗର୍ଭଧାରଣରେ ଚିନ୍ତାଜନ‌କ ହୋଇପାରେ ।[୫] ସ୍ତନ୍ୟପାନ କରାଇବା ସମୟରେ ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।[୫] ଏହା ଆମ୍ପିରୋନ୍ ପରିବାର ସଦସ୍ୟ । [୯] ଏହା ଏକ ଓପିଏଡ୍ ନୁହେଁ; ଓ ଏହାର ଉତ୍ସଗୁଡ଼ିକ ଭିନ୍ନ ହୋଇଥାଏ । [୧୦] [୬]

୧୯୨୨ ମସିହାରେ ମେଟାମିଜୋଲ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ପ୍ରଥମେ ଜର୍ମାନୀରେ ମେଡିକାଲରେ ବ୍ୟବହୃତ ହୋଇଥିଲା । [୧୧] [୧୨] ଏହାକୁ ବିଭିନ୍ନ ବାଣିଜ୍ୟ ନାମରେ ବିକ୍ରି କରାଯାଏ | [୩] ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ହେତୁ ୧୯୬୦ ଏବଂ ୭୦ଦଶକରେ ଆମେରିକା ଏବଂ ଯୁକ୍ତରାଜ୍ୟ ସମେତ ଅନେକ ଦେଶରେ ବଜାରରୁ ଏହା ପ୍ରତ୍ୟାହାର କରାଯାଇଥିଲା। [୧୩] [୭] ଯଦିଓ ଏହା ୨୦୧୯ ସୁଦ୍ଧା ୟୁରୋପର କିଛି ଅଂଶରେ ଏବଂ ବିକାଶଶୀଳ ଦେଶରେ ଉପଲବ୍ଧ ଅଛି। [୫] [୭]

ଆଧାର

[ସମ୍ପାଦନା]
  1. ↑ ୧.୦ ୧.୧ ୧.୨ "Fachinformation (Zusammenfassung der Merkmale des Arzneimittels) Novaminsulfon injekt 1000 mg Lichtenstein Novaminsulfon injekt 2500 mg Lichtenstein" (PDF). Winthrop Arzneimittel GmbH (in German). Zinteva Pharm GmbH. February 2013. Archived from the original on 16 October 2018. Retrieved 19 April 2014.{{cite web}}: CS1 maint: bot: original URL status unknown (link) CS1 maint: unrecognized language (link)
  2. ↑ Brune, K (1997). "The early history of non-opioid analgesics". Acute Pain. 1: 33–40. doi:10.1016/S1366-0071(97)80033-2.
  3. ↑ ୩.୦ ୩.୧ "Metamizole". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 7 May 2021. Retrieved 16 July 2021.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
  4. ↑ ୪.୦ ୪.୧ ୪.୨ ୪.୩ Jage J, Laufenberg-Feldmann R, Heid F (April 2008). "[Drugs for postoperative analgesia: routine and new aspects. Part 1: non-opioids]" [Drugs for postoperative analgesia: routine and new aspects. Part 1: non-opioids]. Der Anaesthesist (in German). 57 (4): 382–90. doi:10.1007/s00101-008-1326-x. PMID 18351305. S2CID 32814418.{{cite journal}}: CS1 maint: unrecognized language (link)
  5. ↑ ୫.୦ ୫.୧ ୫.୨ ୫.୩ ୫.୪ ୫.୫ "Metamizole containing medicinal products". www.ema.europa.eu. Archived from the original on 26 July 2021. Retrieved 16 July 2021.{{cite web}}: CS1 maint: bot: original URL status unknown (link)"Metamizole containing medicinal products". https://www.ema.europa.eu.
  6. ↑ ୬.୦ ୬.୧ Nikolova, Irina; Tencheva, Jasmina; Voinikov, Julian; Petkova, Valentina; Benbasat, Niko; Danchev, Nikolai (January 2012). "Metamizole: A Review Profile of a Well-Known "Forgotten" Drug. Part I: Pharmaceutical and Nonclinical Profile". Biotechnology & Biotechnological Equipment. 26 (6): 3329–3337. doi:10.5504/BBEQ.2012.0089.Nikolova, Irina; Tencheva, Jasmina; Voinikov, Julian; Petkova, Valentina; Benbasat, Niko; Danchev, Nikolai (January 2012).
  7. ↑ ୭.୦ ୭.୧ ୭.୨ Aronson, Jeffrey K. (22 December 2009). Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs (in ଇଂରାଜୀ). Elsevier. p. 198. ISBN 978-0-08-093294-1. Archived from the original on 28 August 2021. Retrieved 16 July 2021.{{cite book}}: CS1 maint: bot: original URL status unknown (link)
  8. ↑ Lutz, Mathias (November 2019). "Metamizole (Dipyrone) and the Liver: A Review of the Literature". The Journal of Clinical Pharmacology. 59 (11): 1433–1442. doi:10.1002/jcph.1512. PMID 31433499.
  9. ↑ Prabhakar, Hemanshu; Ali, Zulfiqar (15 April 2019). Textbook of Neuroanesthesia and Neurocritical Care: Volume I - Neuroanesthesia (in ଇଂରାଜୀ). Springer. p. 442. ISBN 978-981-13-3387-3. Archived from the original on 29 August 2021. Retrieved 16 July 2021.{{cite book}}: CS1 maint: bot: original URL status unknown (link)
  10. ↑ Jasiecka, A; Maślanka, T; Jaroszewski, JJ (2014). "Pharmacological characteristics of metamizole". Polish journal of veterinary sciences. 17 (1): 207–14. doi:10.2478/pjvs-2014-0030. PMID 24724493.
  11. ↑ Fischer, Jnos; Ganellin, C. Robin (2006). [web.archive.org/web/20210829150746/https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA530 Analogue-based Drug Discovery] (in ଇଂରାଜୀ). John Wiley & Sons. p. 530. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2020-09-04. {{cite book}}: Check |archive-url= value (help)
  12. ↑ Silverman, Milton; Lydecker, Mia; Lee, Philip (1 May 1992). Bad Medicine: The Prescription Drug Industry in the Third World (in ଇଂରାଜୀ). Stanford University Press. p. 90. ISBN 978-0-8047-6667-8. Archived from the original on 29 August 2021. Retrieved 16 July 2021.{{cite book}}: CS1 maint: bot: original URL status unknown (link)
  13. ↑ United Nations Department of Economic and Social Affairs (2005). Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted of Not Approved by Governments (PDF) (12th ed.). New York: United Nations. pp. 171–5. Archived from the original on 23 October 2012. Retrieved 3 April 2013.{{cite book}}: CS1 maint: bot: original URL status unknown (link)
"https://or.wikipedia.org/w/index.php?title=ମେଟାମିଜୋଲ&oldid=510690"ରୁ ଅଣାଯାଇଅଛି