ଇପିଲିମୁମାବ

ଇପିଲିମୁମାବ
	Fab fragment of ipilimumab (blue) binding CTLA-4 (green). From PDB entry ଛାଞ୍ଚ:PDBe.
Monoclonal antibody
Type	Whole antibody
Source	Human
Target	CTLA-4
Clinical data
Pronunciation	i pi lim′ ue mab
Trade names	Yervoy
Synonyms	BMS-734016, MDX-010, MDX-101
AHFS/Drugs.com	monograph
MedlinePlus	a611023
data	EU EMA: yes; US DailyMed: Ipilimumab;
Pregnancy; category	AU: C ; US: N (Not classified yet) ; ;
Routes of; administration	Intravenous (IV)
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Chemical and physical data
Formula	C6742H9972N1732O2004S40
Molar mass	୧,୪୮,୬୩୪.୪୬ g·mol−1
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ଇପିଲିମୁମାବ, ଏକ ବେପାର ନାମ ୟେରଭୋଏ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ମେଲାନୋମା, ବୃକ୍‌କୀୟ ଜୀବକୋଷ କର୍କଟ, ମେସୋଥେଲିଓମା ଏବଂ ଅଣ-ଛୋଟ କୋଷ ଫୁସଫୁସ କର୍କଟର (NSCLC) ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ।^[୬] ^[୭] ଏହା ପ୍ରାୟ ନିଭୋଲୁମାବ ସହିତ ଏକତ୍ର ଦିଆଯାଏ ।^[୭] ଏହା ଧୀରେ ଧୀରେ ଏକ ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୭]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରାସ, ଗଲୁ, ଥକାପଣ, ତରଳ ଝାଡ଼ା, ଅଇ, ଜ୍ୱର, ଥାଇରଏଡ୍ ସମସ୍ୟା, ଅଣନିଶ୍ୱାସ, ଯକୃତ ପ୍ରଦାହ ଏବଂ ପେଟ ଯନ୍ତ୍ରଣା ହୋଇପାରେ ।^[୭] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅନ୍ତନଳୀ ପ୍ରଦାହ, ବିଷାକ୍ତ ଏପିଡର୍ମାଲ ନେକ୍ରୋଲାଇସିସ ଏବଂ

ନିଉରୋପାଥି ହୋଇପାରେ ।^[୬] ଏହା ଏକ ମୋନୋକ୍ଲୋନାଲ ଆଣ୍ଟିବଡି ଯାହା ସିଟିଏଲଏ-୪ (CTLA-4 ) ସ‌ହିତ ସଂଯୁକ୍ର ହୋଇ ଅବରୋଧ କରେ ଯାହା ଫଳରେ କର୍କଟ ରୋଗ ବିରୁଦ୍ଧରେ ଟି-କୋଷର କାର୍ଯ୍ୟକଳାପକୁ ବୃଦ୍ଧି କରେଇଥାଏ ।^[୭]

୨୦୧୧ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଇପିଲିମୁମାବ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୭] ^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ୨୦୦ ମିଗ୍ରା ପାଇଁ ପ୍ରାୟ ୧୫,୦୦୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୋଇଛି ।^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶି ପ୍ରାୟ ୩୨,୩୦୦ ଡଲାର ଅଟେ | ^[୯]

ଆଧାର

↑ "Yervoy, ipilimumab (BMS-734016) - Product Profile - BioCentury". BioCentury Online Intelligence. BioCentury Publications. Archived from the original on 12 August 2016. Retrieved 11 August 2016.
↑ USAN. "STATEMENT ON A NONPROPRIETARY NAME ADOPTED BY THE USAN COUNCIL - ipilimumab" (Press release). American Medical Association (AMA). Archived from the original on 2016-02-23. Retrieved 2013-01-12.
↑ "Yervoy EPAR". European Medicines Agency (EMA). Archived from the original on 28 September 2020. Retrieved 2 October 2020.
↑ "Yervoy 5 mg/ml concentrate for solution for infusion - Summary of Product Characteristics (SmPC)". (emc). 3 August 2020. Archived from the original on 22 January 2021. Retrieved 2 October 2020.
↑ "Yervoy- ipilimumab injection". DailyMed. 13 August 2020. Archived from the original on 4 August 2020. Retrieved 2 October 2020.
↑ ^୬.୦ ^୬.୧ ^୬.୨ "Ipilimumab Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 6 May 2021. Retrieved 28 November 2021.
↑ ^୭.୦ ^୭.୧ ^୭.୨ ^୭.୩ ^୭.୪ ^୭.୫ "Yervoy". Archived from the original on 28 September 2020. Retrieved 28 November 2021.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 918. ISBN 978-0857114105.
↑ "Yervoy Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 22 January 2021. Retrieved 28 November 2021.

[1] "Yervoy, ipilimumab (BMS-734016) - Product Profile - BioCentury". BioCentury Online Intelligence. BioCentury Publications. Archived from the original on 12 August 2016. Retrieved 11 August 2016.

[2] USAN. "STATEMENT ON A NONPROPRIETARY NAME ADOPTED BY THE USAN COUNCIL - ipilimumab" (Press release). American Medical Association (AMA). Archived from the original on 2016-02-23. Retrieved 2013-01-12.

[Yervoy_EPAR-3] "Yervoy EPAR". European Medicines Agency (EMA). Archived from the original on 28 September 2020. Retrieved 2 October 2020.

[4] "Yervoy 5 mg/ml concentrate for solution for infusion - Summary of Product Characteristics (SmPC)". (emc). 3 August 2020. Archived from the original on 22 January 2021. Retrieved 2 October 2020.

[Yervoy_FDA_label-5] "Yervoy- ipilimumab injection". DailyMed. 13 August 2020. Archived from the original on 4 August 2020. Retrieved 2 October 2020.

[AHFS2021-6] ୬.୦ ^୬.୧ ^୬.୨ "Ipilimumab Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 6 May 2021. Retrieved 28 November 2021.

[EPAR2021-7] ୭.୦ ^୭.୧ ^୭.୨ ^୭.୩ ^୭.୪ ^୭.୫ "Yervoy". Archived from the original on 28 September 2020. Retrieved 28 November 2021.

[BNF81-8] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 918. ISBN 978-0857114105.

[9] "Yervoy Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 22 January 2021. Retrieved 28 November 2021.

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