ଟ୍ରାଇମେଥୋପ୍ରିମ

ଟ୍ରାଇମେଥୋପ୍ରିମ (INN)
Clinical data
Pronunciation	/traɪˈmɛθəprɪm/
Trade names	Proloprim, Monotrim, Triprim, others
AHFS/Drugs.com	monograph
MedlinePlus	a684025
data	US FDA: Trimethoprim;
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Routes of; administration	Oral
ATC code	J01EA01 (WHO) QJ51EA01 (WHO);
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	90–100%
Protein binding	44%
Metabolism	hepatic
Elimination half-life	8-12 hours
Excretion	Urine (50–60%), faeces (4%)
Identifiers
	IUPAC name 5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine;
CAS Number	738-70-5 ;
PubChem CID	5578;
DrugBank	DB00440 ;
ChemSpider	5376 ;
UNII	AN164J8Y0X;
KEGG	D00145 ;
ChEBI	CHEBI:45924 ;
ChEMBL	CHEMBL22 ;
PDB ligand	TOP (PDBe, RCSB PDB);
ECHA InfoCard	100.010.915
Chemical and physical data
Formula	C14H18N4O3
Molar mass	290.32 g/mol
3D model (JSmol)	Interactive image;
	SMILES COc1cc(cc(c1OC)OC)Cc2cnc(nc2N)N;
	InChI InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) ; Key:IEDVJHCEMCRBQM-UHFFFAOYSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Trimethoprim

ଟ୍ରାଇମେଥୋପ୍ରିମ ଏକ ପ୍ରକାର ଆଣ୍ଟିବାୟୋଟିକ ଯାହା ମୂଖ୍ୟତଃ ମୁତ୍ରପଥ ସଂକ୍ରମଣର ଚିକିତ୍ସା ନିମନ୍ତେ ବ୍ୟବ‌ହାର କରାଯାଏ ।^[୧] ଅନ୍ୟ ରୋଗ ଯଥା:- ତୀବ୍ର ମଧ୍ୟ କର୍ଣ୍ଣ ସଂକ୍ରମଣ ଓ ପର୍ଯ୍ୟଟକ ତରଳ ଝାଡ଼ା ନିମନ୍ତେ ମଧ୍ୟ ବ୍ୟବ‌ହାର କରାଯାଏ । ଏଚଆଇବି ରୋଗୀଙ୍କର ନିମୋସିସ୍ଟକ ନିମୋନିଆ ହୋଇଥିଲେ ଟ୍ରାଇମେଥୋପ୍ରିମ ସ‌ହିତ ସଲଫାମେଥୋକ୍‌ସାଜୋଲ ବା ଡାପସୋନ ମିଶେଇ ଦିଆଯାଏ ।^[୧]^[୨] ଏହି ଔଷଧ ଖାଇବାକୁ ଦିଆଯାଏ ।^[୧]

ଟ୍ରାଇମେଥୋପ୍ରିମର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ମଧ୍ୟରେ ଅଇ, ସ୍ୱାଦ ପରିବର୍ତ୍ତନ ଓ ରାସ୍ ମୂଖ୍ୟ । କ୍ୱଚିତ ପ୍ଲାଟେଲେଟ ବା ଶ୍ୱେତ ରକ୍ତ କଣିକା ସଂଖ୍ୟା କମିଯିବା ଦେଖାଯାଏ । ଏହା ଯୋଗୁ ସୂର୍ଯ୍ୟାଲୋକ ସମ୍ବେଦନଶୀଳ ହୋଇପାରେ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ପଶୁମାନଙ୍କର ହାନୀ ହେଲେ ମଧ୍ୟ ମହିଳାଙ୍କର ହାନୀ ଦେଖାଯାଇ ନାହିଁ ।^[୩] ଜୀବାଣୁ ଦେହରେ ଫୋଲେଟ ମେଟାବୋଲିଜ୍ମ ପ୍ରତିରୋଧ କରି ଏହା ତାହାକୁ ମାରିଦିଏ ।^[୧]

ଟ୍ରାଇମେଥୋପ୍ରିମ ପ୍ରଥମେ ସନ ୧୯୬୨ରେ ବ୍ୟବ‌ହୃତ ହେଲା ।^[୪]ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୫] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ ଉପଲବ୍‌ଧ ହୁଏ ଓ ଦାମିକା ନୁହେଁ । ^[୬] ଆମେରିକାରେ ଏହାର ୧୦ ଦିନର ଖର୍ଚ୍ଚ ୨୧ ଆମେରିକୀୟ ଡଲାର ।^[୧]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Trimethoprim". The American Society of Health-System Pharmacists. Retrieved Aug 1, 2015.
↑ Masur, H; Brooks, JT; Benson, CA; Holmes, KK; Pau, AK; Kaplan, JE; National Institutes of, Health; Centers for Disease Control and, Prevention; HIV Medicine Association of the Infectious Diseases Society of, America (May 2014). "Prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: Updated Guidelines from the Centers for Disease Control and Prevention, National Institutes of Health, and HIV Medicine Association of the Infectious Diseases Society of America". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 58 (9): 1308–11. PMID 24585567.
↑ "Prescribing medicines in pregnancy database". Australian Government. 3 March 2014. Retrieved 22 April 2014.
↑ Huovinen, P (1 June 2001). "Resistance to trimethoprim-sulfamethoxazole". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 32 (11): 1608–14. PMID 11340533.
↑ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 113. ISBN 9781284057560.

[AHFS2015-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Trimethoprim". The American Society of Health-System Pharmacists. Retrieved Aug 1, 2015.

[2] Masur, H; Brooks, JT; Benson, CA; Holmes, KK; Pau, AK; Kaplan, JE; National Institutes of, Health; Centers for Disease Control and, Prevention; HIV Medicine Association of the Infectious Diseases Society of, America (May 2014). "Prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: Updated Guidelines from the Centers for Disease Control and Prevention, National Institutes of Health, and HIV Medicine Association of the Infectious Diseases Society of America". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 58 (9): 1308–11. PMID 24585567.

[TGA2014-3] "Prescribing medicines in pregnancy database". Australian Government. 3 March 2014. Retrieved 22 April 2014.

[Huo2001-4] Huovinen, P (1 June 2001). "Resistance to trimethoprim-sulfamethoxazole". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 32 (11): 1608–14. PMID 11340533.

[5] "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[Ric2015-6] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 113. ISBN 9781284057560.

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