ଟାପେଣ୍ଟାଡୋଲ

ଟାପେଣ୍ଟାଡୋଲ
Clinical data
Trade names	Nucynta, Palexia, Yantil, others
Synonyms	BN-200, CG-5503, R-331333
AHFS/Drugs.com	monograph
MedlinePlus	a610006
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Addiction; liability	High
Routes of; administration	By mouth
Legal status
Legal status	AU: S8 (Controlled) ; CA: Schedule I ; DE: Anlage III (Prescription only) ; UK: Class A (Schedule 2 CD) ; US: Schedule II ;
Pharmacokinetic data
Bioavailability	32% (by mouth)
Protein binding	20%
Metabolism	Liver (mostly via glucuronidation but also by CYP2C9, CYP2C19, CYP2D6)
Onset of action	30 min
Elimination half-life	4 hours< (duration 4-6 hours)
Duration of action	4 to 6 hr
Excretion	Urine and feces (1%)
Identifiers
	IUPAC name 3-[(1R,2R)-3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol;
ECHA InfoCard	100.131.247
Chemical and physical data
Formula	C14H23NO
Molar mass	୨୨୧.୩୪ g·mol−1
3D model (JSmol)	Interactive image;
Boiling point	(decomposes)
	SMILES Oc1cc(ccc1)[C@@H]([C@@H](C)CN(C)C)CC;
	InChI InChI=1S/C14H23NO/c1-5-14(11(2)10-15(3)4)12-7-6-8-13(16)9-12/h6-9,11,14,16H,5,10H2,1-4H3/t11-,14+/m0/s1 ; Key:KWTWDQCKEHXFFR-SMDDNHRTSA-N ;
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ଟାପେଣ୍ଟାଡୋଲ, ବେପାର ନାମ ନ୍ୟୁସିଣ୍ଟା, ହେଉଛି ଏକ ଓପିଓଏଡ ଯନ୍ତ୍ରଣା ନିବାରକ ଔଷଧ ।^[୧] ଏହା ସ୍ୱଳ୍ପ କିମ୍ବା ଦୀର୍ଘକାଳୀନ ହେଉଥିବା ମଧ୍ୟମରୁ ପ୍ରବଳ ଯନ୍ତ୍ରଣା ପାଇଁ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୧] ^[୬] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୧] ଏହାର ପ୍ରଭାବର ଆରମ୍ଭ ପ୍ରାୟ ୩୦ ମିନିଟ ମଧ୍ୟରେ ହୁଏ ଏବଂ ୪-୬ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ ।^[୪] ^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ନିଦ୍ରାଳୁ ଭାବ, କୋଷ୍ଠକାଠିନ୍ୟ ଏବଂ ଗଲୁ ହୋଇପାରେ ।^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାତ, ନିମ୍ନ ରକ୍ତଚାପ, ନିଶାଗ୍ରସ୍ତ, ସେରୋଟୋନିନ ସିଣ୍ଡ୍ରୋମ ଏବଂ ଶ୍ୱାସକ୍ରିୟା ଅଭାବ (ଶ୍ୱାସକ୍ରିୟା ଅବସାଦ) ହୋଇପାରେ। ^[୧] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୧] ଅପବ୍ୟବହାର ହେବାର ଆଶଙ୍କା ଅନ୍ୟ ଶକ୍ତିଶାଳୀ ଓପିଓଏଡ୍ ସହିତ ସମାନ ।^[୧] ଯଦିଓ ଏହାର କାର୍ଯ୍ୟ ପ୍ରଣାଳୀ ସମ୍ପୂର୍ଣ୍ଣ ସ୍ପଷ୍ଟ ନୁହେଁ, ଏହା μ- ଓପିଓଏଡ୍ ରିସେପ୍ଟର ଉପରେ କାର୍ଯ୍ୟ କରିଥାଏ ଏବଂ ଉଭୟ ସେରୋଟୋନିନ୍ ଏବଂ ନରଏପିନେଫ୍ରିନ ସ୍ତରକୁ ବୃଦ୍ଧି କରିଥାଏ ।^[୧]

୨୦୦୮ରେ ଆମେରିକାରେ,^[୧] ୨୦୧୦ରେ ଅଷ୍ଟ୍ରେଲିଆରେ,^[୭] ଏବଂ ୨୦୧୧ରେ ବ୍ରିଟେନ ଏବଂ ଭାରତରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଟାପେଣ୍ଟାଡୋଲକୁ ଅନୁମୋଦନ କରାଯାଇଥିଲା ।^[୮] ^[୯] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୫୦ ମି:ଗ୍ରା ବିଶିଷ୍ଟ ୩୦ଟି ବଟିକାର ମୂଲ୍ୟ ୨୩୦ ଡଲାର ।^[୧୦] ଏହି ପରିମାଣର ଔଷଧର ମୂଲ୍ୟ ଯୁକ୍ତରାଜ୍ୟରେ ମୂଲ୍ୟ £୧୫ । ^[୬] ଏହା ଧୀର ନିଷ୍କାସନ ଆକାରରେ ବାହାରିଥାଏ । ^[୬]

ଆଧାର

↑ ^୧.୦୦ ^୧.୦୧ ^୧.୦୨ ^୧.୦୩ ^୧.୦୪ ^୧.୦୫ ^୧.୦୬ ^୧.୦୭ ^୧.୦୮ ^୧.୦୯ ^୧.୧୦ "Tapentadol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 March 2021. Retrieved 22 September 2021.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ Fidman, B; Nogid, A (2010). "Role of Tapentadol Immediate Release (Nucynta) in the Management Of Moderate-to-Severe Pain". Pharmacy and Therapeutics. 35 (6): 330–357. PMC 2888545.
↑ Brayfield, A, ed. (14 November 2011). "Tapentadol". Martindale: The Complete Drug Reference. Pharmaceutical Press. Archived from the original on 29 August 2021. Retrieved 2 April 2014.
↑ ^୪.୦ ^୪.୧ Emmett, Stevan R.; Hill, Nicola; Dajas-Bailador, Federico (30 October 2019). Clinical Pharmacology for Prescribing (in ଇଂରାଜୀ). Oxford University Press. p. 441. ISBN 978-0-19-258564-6. Archived from the original on 22 September 2021. Retrieved 22 September 2021.
↑ ^୫.୦ ^୫.୧ Fischer, János; Ganellin, C. Robin; Rotella, David P. (15 October 2012). Analogue-based Drug Discovery III (in ଇଂରାଜୀ). John Wiley & Sons. p. 44. ISBN 978-3-527-65110-8. Archived from the original on 22 September 2021. Retrieved 22 September 2021.
↑ ^୬.୦ ^୬.୧ ^୬.୨ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 491. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "TGA eBS - Product and Consumer Medicine Information Licence". www.ebs.tga.gov.au. Archived from the original on 30 March 2020. Retrieved 22 September 2021.
↑ "Palexia film coated tablets". electronic Medicines Compendium. Grunenthal Ltd. 13 November 2013. Archived from the original on 7 April 2014. Retrieved 2 April 2014.
↑ Mukherjee, Diptadhi; Shukla, Lekhansh; Saha, Priyanka; Mahadevan, Jayant; Kandasamy, Arun; Chand, Prabhat; Benegal, Vivek; Murthy, Pratima (March 2020). "Tapentadol abuse and dependence in India". Asian Journal of Psychiatry (in ଇଂରାଜୀ). 49: 101978. doi:10.1016/j.ajp.2020.101978. PMID 32120298.
↑ "Nucynta Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 10 March 2021. Retrieved 22 September 2021.

[AHFS2021-1] ୧.୦୦ ^୧.୦୧ ^୧.୦୨ ^୧.୦୩ ^୧.୦୪ ^୧.୦୫ ^୧.୦୬ ^୧.୦୭ ^୧.୦୮ ^୧.୦୯ ^୧.୧୦ "Tapentadol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 March 2021. Retrieved 22 September 2021.

[Fidman2010rev-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ Fidman, B; Nogid, A (2010). "Role of Tapentadol Immediate Release (Nucynta) in the Management Of Moderate-to-Severe Pain". Pharmacy and Therapeutics. 35 (6): 330–357. PMC 2888545.

[MD-3] Brayfield, A, ed. (14 November 2011). "Tapentadol". Martindale: The Complete Drug Reference. Pharmaceutical Press. Archived from the original on 29 August 2021. Retrieved 2 April 2014.

[Onset2019-4] ୪.୦ ^୪.୧ Emmett, Stevan R.; Hill, Nicola; Dajas-Bailador, Federico (30 October 2019). Clinical Pharmacology for Prescribing (in ଇଂରାଜୀ). Oxford University Press. p. 441. ISBN 978-0-19-258564-6. Archived from the original on 22 September 2021. Retrieved 22 September 2021.

[Duration2012-5] ୫.୦ ^୫.୧ Fischer, János; Ganellin, C. Robin; Rotella, David P. (15 October 2012). Analogue-based Drug Discovery III (in ଇଂରାଜୀ). John Wiley & Sons. p. 44. ISBN 978-3-527-65110-8. Archived from the original on 22 September 2021. Retrieved 22 September 2021.

[BNF80-6] ୬.୦ ^୬.୧ ^୬.୨ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 491. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[7] "TGA eBS - Product and Consumer Medicine Information Licence". www.ebs.tga.gov.au. Archived from the original on 30 March 2020. Retrieved 22 September 2021.

[8] "Palexia film coated tablets". electronic Medicines Compendium. Grunenthal Ltd. 13 November 2013. Archived from the original on 7 April 2014. Retrieved 2 April 2014.

[Dip2020-9] Mukherjee, Diptadhi; Shukla, Lekhansh; Saha, Priyanka; Mahadevan, Jayant; Kandasamy, Arun; Chand, Prabhat; Benegal, Vivek; Murthy, Pratima (March 2020). "Tapentadol abuse and dependence in India". Asian Journal of Psychiatry (in ଇଂରାଜୀ). 49: 101978. doi:10.1016/j.ajp.2020.101978. PMID 32120298.

[GX2021-10] "Nucynta Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 10 March 2021. Retrieved 22 September 2021.

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