ଲର୍ବିନେକ୍ଟେଡିନ

ଲର୍ବିନେକ୍ଟେଡିନ
Clinical data
Pronunciation	/ˌlɜːrbɪˈnɛktɪdin/; LUR-BI-NEK-TI-deen
Trade names	Zepzelca
Synonyms	PM-01183
AHFS/Drugs.com	monograph
MedlinePlus	a620049
data	US DailyMed: Lurbinectedin;
Pregnancy; category	AU: D ;
Routes of; administration	Intravenous
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ;
Identifiers
	IUPAC name [(1R,2R,3R,11S,12S,14R,26R)-5,12-dihydroxy-6,6'-dimethoxy-7,21,30-trimethyl-27-oxospiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triaconta-4(9),5,7,15,20,22-hexaene-26,1'-2,3,4,9-tetrahydropyrido[3,4-b]indole]-22-yl] acetate;
Chemical and physical data
Formula	C41H44N4O10S
Molar mass	୭୮୪.୮୮ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC2=C([C@@H]3[C@@H]4[C@H]5C6=C(C(=C7C(=C6[C@@H](N4[C@H]([C@H](C2)N3C)O)COC(=O)[C@@]8(CS5)C9=C(CCN8)C2=C(N9)C=CC(=C2)OC)OCO7)C)OC(=O)C)C(=C1OC)O;
	InChI InChI=1S/C41H44N4O10S/c1-17-11-20-12-25-39(48)45-26-14-52-40(49)41(38-22(9-10-42-41)23-13-21(50-5)7-8-24(23)43-38)15-56-37(31(45)30(44(25)4)27(20)32(47)33(17)51-6)29-28(26)36-35(53-16-54-36)18(2)34(29)55-19(3)46/h7-8,11,13,25-26,30-31,37,39,42-43,47-48H,9-10,12,14-16H2,1-6H3/t25-,26-,30+,31+,37+,39-,41+/m0/s1; Key:YDDMIZRDDREKEP-HWTBNCOESA-N;

ଲର୍ବିନେକ୍ଟେଡିନ (ଇଂରାଜୀ ଭାଷାରେ Lurbinectedin), ଜେପଜେଲକା ଏହାର ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଛୋଟ କୋଷ ଫୁସଫୁସ କର୍କଟ (SCLC) ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ଅନ୍ୟାନ୍ୟ ଚିକିତ୍ସା ସତ୍ତ୍ୱେ ଏହି ରୋଗ ବ୍ୟାପୁଥିଲେ ଏହା ବ୍ୟବହୃତ ହୁଏ | ^[୨] ଏହା ଏକ ଶିରାରେ ଧୀରେ ଧୀରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।| ^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତ କଣିକା, ସ୍ୱଳ୍ପ ଲୋହିତ ରକ୍ତ କଣିକା, ବୃକ୍‌କ ସମସ୍ୟା, କମ ରକ୍ତ ପ୍ଲାଟେଲେଟ୍, ଅଇ, ମାଂସପେଶୀ ଯନ୍ତ୍ରଣା, ଅଣନିଶ୍ୱାସ, ଯକୃତ ପ୍ରଦାହ ଏବଂ କୋଷ୍ଠକାଠିନ୍ୟ ହୋଇପାରେ ।^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅନୁର୍ବରତା ହୋଇପାରେ ।^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୨] ଏହା ଏକ ଆଲକିଲେଟିଂ ଏଜେଣ୍ଟ ।^[୨] କୋଷ ବିଭାଜନ ପାଇଁ ଆବଶ୍ୟକ ଡିଏନଏ ପ୍ରତିରୂପ କରିବାରେ ହସ୍ତକ୍ଷେପ କରି ଏହା କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୩]

୨୦୨୦ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୨୧ରେ ଅଷ୍ଟ୍ରେଲିଆରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର କରିବା ପାଇଁ ଲର୍ବିନେକ୍ଟେଡିନ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ୪ ମିଗ୍ରାର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୭,୨୦୦ ଡଲାର ଥିଲା ।^[୫] ୨୦୨୧ ସୁଦ୍ଧା ଏହା ବ୍ରିଟେନ କିମ୍ବା ୟୁରୋପରେ ଉପଲବ୍ଧ ହୋଇନଥିଲା ।^[୬]

ଆଧାର

1 2 3 "Zepzelca". Therapeutic Goods Administration (TGA). 22 September 2021. Archived from the original on 30 September 2021. Retrieved 30 September 2021.
1 2 3 4 5 6 7 8 "Zepzelca- lurbinectedin injection, powder, lyophilized, for solution". DailyMed. 15 June 2020. Archived from the original on 24 January 2021. Retrieved 24 September 2020.
↑ "Lurbinectedin". National Cancer Institute. Archived from the original on 16 May 2020. Retrieved 15 June 2020.
↑ "Lurbinectedin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 24 November 2021.
↑ "Zepzelca Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 24 November 2021.
↑ "Lurbinectedin". SPS - Specialist Pharmacy Service. 13 September 2016. Archived from the original on 8 December 2021. Retrieved 24 November 2021.

[Au2021-1] 1 2 3 "Zepzelca". Therapeutic Goods Administration (TGA). 22 September 2021. Archived from the original on 30 September 2021. Retrieved 30 September 2021.

[PI2021-2] 1 2 3 4 5 6 7 8 "Zepzelca- lurbinectedin injection, powder, lyophilized, for solution". DailyMed. 15 June 2020. Archived from the original on 24 January 2021. Retrieved 24 September 2020.

[NCI2021-3] "Lurbinectedin". National Cancer Institute. Archived from the original on 16 May 2020. Retrieved 15 June 2020.

[AHFS2021-4] "Lurbinectedin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 24 November 2021.

[5] "Zepzelca Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 24 November 2021.

[6] "Lurbinectedin". SPS - Specialist Pharmacy Service. 13 September 2016. Archived from the original on 8 December 2021. Retrieved 24 November 2021.

[୧]

[୨]

[୩]

[୪]

[୫]

[୬]