ଆମୋକ୍ସାପାଇନ

ଆମୋକ୍ସାପାଇନ
Clinical data
Pronunciation	a mox' a peen
Trade names	Asendin, others
AHFS/Drugs.com	monograph
MedlinePlus	a682202
data	US FDA: Amoxapine;
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	by mouth
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	>60%
Protein binding	90%
Metabolism	Liver (cytochrome P450 system)
Elimination half-life	8–10 hours (30 hours for chief active metabolite)
Excretion	Kidney (60%), feces (18%)
Identifiers
	IUPAC name 2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine;
ECHA InfoCard	100.034.411
Chemical and physical data
Formula	C17H16ClN3O
Molar mass	୩୧୩.୭୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc2ccc1Oc4c(/N=C(\c1c2)N3CCNCC3)cccc4;
	InChI InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2 ; Key:QWGDMFLQWFTERH-UHFFFAOYSA-N ;
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ଆମୋକ୍ସାପାଇନ, ଏକ ବେପାର ନାମ ଆସେଣ୍ଡିନ, ଅବସାଦ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ । ^[୪] ଏଥିରେ ସାଇକୋସିସ କିମ୍ବା ଉଦ୍‌ବେଗ ସହିତ ଉଦାସୀନତା ଅନ୍ତର୍ଭୁକ୍ତ ଅଟେ । ^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୪] ପ୍ରଭାବ ଆରମ୍ଭ ନିମନ୍ତେ ୨ ସପ୍ତାହ ଲାଗିପାରେ । ^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ ଭାବ, ମୁଣ୍ଡ ବୁଲାଇବା, ମୁଣ୍ଡବିନ୍ଧା, ଅସ୍ପଷ୍ଟ ଦୃଷ୍ଟିଶକ୍ତି, ଶୁଖିଲା ପାଟି ଏବଂ କମ୍ପନ ଅନ୍ତର୍ଭୁକ୍ତ | ^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଏକ୍ସଟ୍ରାପିରାମିଡାଲ ଲକ୍ଷଣ, ଟାର୍ଡିଭ୍ ଡିସକାଇନେସିଆ, ଆତ୍ମହତ୍ୟା ଚିନ୍ତାଧାରା, ହୃତ୍‌ପିଣ୍ଡ ଆରିଥମିଆ ଏବଂ ଦୁଗ୍ଧ ଉତ୍ପାଦନ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ । ^[୧] ଗର୍ଭାବସ୍ଥାରେ ନିରାପତ୍ତା ଅସ୍ପଷ୍ଟ ଥିବାବେଳେ ଅନ୍ୟ ପ୍ରାଣୀମାନଙ୍କରେ କ୍ଷତି ଦେଖିବାକୁ ମିଳିଛି। ^[୫] ଏହା ଏକ ଟେଟ୍ରାସାଇକ୍ଲିକ୍ ଆଣ୍ଟିଡିପ୍ରେସାଣ୍ଟ ଏବଂ ନରେପିନେଫ୍ରିନ‌କୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହେଉଥିବା ବିଶ୍ୱାସ କରାଯାଏ । ^[୧]

୧୯୮୦ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଆମୋକ୍ସାପାଇନ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା | ^[୪] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । ^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏକ ମାସର ଚିକିତ୍ସା ୨୦୨୨ ସୁଦ୍ଧା ପ୍ରାୟ ୫୦ ଡଲାର ଅଟେ । ^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Amoxapine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 14 January 2022. Retrieved 14 January 2022.
↑ ^୨.୦ ^୨.୧ ^୨.୨ "Asendin, (amoxapine) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 2 December 2013. Retrieved 26 November 2013.
↑ ^୩.୦ ^୩.୧ Kinney, JL; Evans, RL (September–October 1982). "Evaluation of amoxapine". Clinical Pharmacy. 1 (5): 417–24. PMID 6764165.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ "Amoxapine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2013. Retrieved 14 January 2022.
↑ "Amoxapine (Asendin) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 25 November 2020. Retrieved 14 January 2022.
↑ ^୬.୦ ^୬.୧ "Amoxapine Prices, Coupons & Savings Tips". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Archived from the original on 14 January 2022. Retrieved 14 January 2022.

[Liv2022-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Amoxapine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 14 January 2022. Retrieved 14 January 2022.

[MSR-2] ୨.୦ ^୨.୧ ^୨.୨ "Asendin, (amoxapine) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 2 December 2013. Retrieved 26 November 2013.

[pmid6764165-3] ୩.୦ ^୩.୧ Kinney, JL; Evans, RL (September–October 1982). "Evaluation of amoxapine". Clinical Pharmacy. 1 (5): 417–24. PMID 6764165.

[AHFS2022-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ "Amoxapine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2013. Retrieved 14 January 2022.

[5] "Amoxapine (Asendin) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 25 November 2020. Retrieved 14 January 2022.

[GX2022-6] ୬.୦ ^୬.୧ "Amoxapine Prices, Coupons & Savings Tips". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Archived from the original on 14 January 2022. Retrieved 14 January 2022.

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