ହାୟୋସିନ ବ୍ୟୁଟାଇଲବ୍ରୋମାଇଡ

ହାୟୋସିନ ବ୍ୟୁଟାଇଲବ୍ରୋମାଇଡ
Clinical data
Trade names	Buscopan
Pregnancy; category	AU: B2 ;
Routes of; administration	Oral, rectal, intravenous
ATC code	A03BB01 (WHO) ;
Legal status
Legal status	AU: S2 (Pharmacy only) ; UK: General sales list (GSL, OTC) ;
Pharmacokinetic data
Bioavailability	<1%
Protein binding	Low
Elimination half-life	5 hours
Excretion	Renal (50%) [ଆଧାର ଲୋଡ଼ା] and fecal
Identifiers
	IUPAC name [7(S)-(1α,2β,4β,5α,7β)]-9-butyl-7-(3-hydroxy-; 1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-; 9-azonitricyclo[3.3.1.0(2,4)]nonane;
CAS Number	149-64-4 ;
PubChem CID	160883;
DrugBank	DB09300 ;
ChemSpider	16736107 ;
UNII	2Z3E1OF81V;
ChEMBL	CHEMBL1256901 ;
ECHA InfoCard	100.005.223
Chemical and physical data
Formula	C21H30NO4+
Molar mass	360.467 g/mol
3D model (JSmol)	Interactive image;
	SMILES [Br-].OC[C@H](c1ccccc1)C(=O)O[C@@H]2C[C@@H]3[C@H]4O[C@H]4[C@H](C2)[N+]3(C)CCCC;
	InChI InChI=1S/C21H30NO4.BrH/c1-3-4-10-22(2)17-11-15(12-18(22)20-19(17)26-20)25-21(24)16(13-23)14-8-6-5-7-9-14;/h5-9,15-20,23H,3-4,10-13H2,1-2H3;1H/q+1;/p-1/t15-,16-,17-,18+,19-,20+,22?;/m1./s1 ; Key:HOZOZZFCZRXYEK-GSWUYBTGSA-M ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Hyoscine_butylbromide

ହାୟୋସିନ ବ୍ୟୁଟାଇଲବ୍ରୋମାଇଡ, ଅନ୍ୟ ନାମ ସ୍କୋପୋଲାମିନ ବ୍ୟୁଟାଇଲବ୍ରୋମାଇଡ, ^[୧] ବିକ୍ରୟ ନାମ ବୁସ୍କୋପାନ,^[୨] ଏକ ଔଷଧ ଯାହା ପେଶୀ ଶୂଳ ହେଉଥିବା ପେଟ ଯନ୍ତ୍ରଣା, ବୃକ୍କ ଶୂଳ (renal colic) ଓ ମୂତ୍ରାଶୟ ଅତିସଙ୍କୁଚନ (bladder spasm) ଇତ୍ୟାଦି ବେମାରୀରେ ଦିଆଯାଏ । ^[୨]^[୩] ଜୀବନ ଦୀପ ଲିଭିଆସୁଥିବା ବେଳେ ମୃତ୍ୟୁସ୍ୱନରେ ଉନ୍ନତି ଆଣିବା ନିମନ୍ତେ ଏହା ବ୍ୟବ‌ହାର କରାଯାଏ । ^[୪] ଏହା ପାଟିରେ, ମାଂସପେଶୀ ଓ ଶିରାଭ୍ୟନ୍ତର ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ । ^[୨]

ଏହାର ମୂଖ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାମାନ ଯଥାକ୍ରମେ ନିଦ୍ରାଳୁତା, ଦୃଷ୍ଟି ପରିବର୍ତ୍ତନ, ସାଂଘାତିକ ଆଲର୍ଜୀ ଓ ଗ୍ଲକୋମା ରୋଗ ସକ୍ରିୟ କରାଏ ।^[୨] ନିଦ୍ରାଳୁତା କମ ଦେଖାଯାଏ ।^[୫] ଗର୍ଭାବସ୍ଥାରେ ଏହାର ନିରାପତ୍ତା ସ୍ପଷ୍ଟ ନୁହେଁ ।^[୨] ଏହା ଏକ ଆଣ୍ଟିକଲିନର୍ଜିକ ଏଜେଣ୍ଟ,^[୨] ଯାହାର କେନ୍ଦ୍ରୀୟ ସ୍ନାୟୁମଣ୍ଡଳ ଉପରେ ବିଶେଷ ପ୍ରଭାବ ପଡ଼େନି ।^[୬]

ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ । ^[୭] ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ମିଳେନାହିଁ ।^[୮]ଗୋଟିଏ ପିଲ ପିଛା ଏହାର ମୂଲ୍ୟ ସନ ୨୦୧୪ରେ ୦.୦୦୪ରୁ ୦.୧୧ ଆମେରିକୀୟ ଡଲାର ଥିଲା ।^[୯] ଏହା ହାୟୋସିନରୁ ପ୍ରସ୍ତୁତ କରାଯାଏ ଯାହା ଆଟ୍ରୋପିନ ବେଲାଡୋନା ଗଛରେ ଥାଏ ।^[୧୦]

ଆଧାର

↑ Juo, Pei-Show (2001). Concise Dictionary of Biomedicine and Molecular Biology (2nd ed.). Hoboken: CRC Press. p. 570. ISBN 9781420041309.
1 2 3 4 5 6 "BUSCOPAN Tablets and Ampoules BUSCOPAN FORTE Tablets". TGA eBusiness Services. BOEHRINGER INGELHEIM PTY LIMITED. 8 November 2010. Retrieved 22 October 2013.
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 270. ISBN 9781284057560.
↑ Paice, Judith (2015). Care of the Imminently Dying. Oxford University Press. p. 43. ISBN 9780190244309.
↑ Handbook of Palliative Care (3rd ed.). New York: Wiley. 2012. p. 570. ISBN 9781118426814.
↑ Hanks, Geoffrey (2011). Oxford textbook of palliative medicine (4th ed.). Oxford [etc.]: Oxford University Press. p. 805. ISBN 9780199693146.
↑ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
↑ Territo, editor, Dennis A. Casciato ; associate editor, Mary C. (2012). Manual of clinical oncology (7th ed.). Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins Health. p. 146. ISBN 9781451115604. {{cite book}}: |first1= has generic name (help)CS1 maint: multiple names: authors list (link)
↑ "Hyoscine Butylbromide". International Drug Price Indicator Guide. Archived from the original on 10 May 2017. Retrieved 4 December 2015.
↑ Twycross, Robert (2003). Introducing palliative care (4th ed.). Oxford: Radcliffe Medical Press. p. 172. ISBN 9781857759150.

[Huo2001-1] Juo, Pei-Show (2001). Concise Dictionary of Biomedicine and Molecular Biology (2nd ed.). Hoboken: CRC Press. p. 570. ISBN 9781420041309.

[TGA2010-2] 1 2 3 4 5 6 "BUSCOPAN Tablets and Ampoules BUSCOPAN FORTE Tablets". TGA eBusiness Services. BOEHRINGER INGELHEIM PTY LIMITED. 8 November 2010. Retrieved 22 October 2013.

[Ric2015-3] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 270. ISBN 9781284057560.

[4] Paice, Judith (2015). Care of the Imminently Dying. Oxford University Press. p. 43. ISBN 9780190244309.

[5] Handbook of Palliative Care (3rd ed.). New York: Wiley. 2012. p. 570. ISBN 9781118426814.

[6] Hanks, Geoffrey (2011). Oxford textbook of palliative medicine (4th ed.). Oxford [etc.]: Oxford University Press. p. 805. ISBN 9780199693146.

[7] "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[8] Territo, editor, Dennis A. Casciato ; associate editor, Mary C. (2012). Manual of clinical oncology (7th ed.). Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins Health. p. 146. ISBN 9781451115604. {{cite book}}: |first1= has generic name (help)CS1 maint: multiple names: authors list (link)

[9] "Hyoscine Butylbromide". International Drug Price Indicator Guide. Archived from the original on 10 May 2017. Retrieved 4 December 2015.

[10] Twycross, Robert (2003). Introducing palliative care (4th ed.). Oxford: Radcliffe Medical Press. p. 172. ISBN 9781857759150.

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