ସାପ୍ରୋପ୍ଟେରିନ

Sapropterin
Clinical data
Trade names	Kuvan, Biopten, other
Synonyms	Tetrahydrobiopterin
AHFS/Drugs.com	monograph
MedlinePlus	a608020
data	EU EMA: yes; US DailyMed: Sapropterin;
Pregnancy; category	AU: B1 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; US: ℞-only ; ℞ (Prescription only);
Pharmacokinetic data
Elimination half-life	4 hours (healthy adults); 6–7 hours (PKU patients)
Duration of action	24 hours
Identifiers
	IUPAC name (6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(1H)-one;
ECHA InfoCard	100.164.121
Chemical and physical data
Formula	C9H15N5O3
Molar mass	୨୪୧.୨୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C(C1CNC2=C(N1)C(=O)N=C(N2)N)O)O;
	InChI InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,4+,6-/m0/s1 ; Key:FNKQXYHWGSIFBK-RPDRRWSUSA-N ;
(verify)

ସାପ୍ରୋପ୍ଟେରିନ, ଯାହାକୁ ଟେଟ୍ରାହାଇଡ୍ରୋବାୟୋପ୍ଟେରିନ (BH₄, THB ) ମଧ୍ୟ କୁହାଯାଏ, ଏକ ଔଷଧ ଯାହା ଫିନାଇଲକିଟୋନୁରିଆ କିମ୍ବା ଟେଟ୍ରାହାଇଡ୍ରୋବିଓପେରିନ ଅଭାବ ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ^[୩] ଏହା ଖାଦ୍ୟପେୟ ପରିବର୍ତ୍ତନ ସହିତ ଏକତ୍ର ଏହି ଔଷଧ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ପ୍ରଥମ ମାସରେ ଏହା ପ୍ରଭାବଶାଳୀ କି ନୁହେଁ ତାହା ଜାଣିବା ପାଇଁ ରକ୍ତରେ ଫିନାଇଲଆଲାନିନ ସ୍ତର ମାପ କରାଯାଏ ।^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା ଏବଂ ନାକରୁ ତରଳ ପଦାର୍ଥ ପ୍ରବାହିତ ହୁଏ ।^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲକ୍‌ସିସ, ପାକସ୍ଥଳୀ ପ୍ରଦାହ ଏବଂ ହାଇପରଆକ୍ଟିଭିଟି ହୋଇପାରେ।^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାରକୁ ବିଚାର କରାଯାଇପାରେ ଯଦି କେବଳ ଫିନାଇଲଆଲାନିନ ସ୍ତରକୁ ଉପ‌ଯୁକ୍ତ ଖାଦ୍ୟ ନିୟନ୍ତ୍ରଣ କରିପାରେ ନାହିଁ ।^[୪] ଏହା ଏକ କୋଫାକ୍ଟର ଯାହା ଫେନିଲାଲାନାଇନ୍ ହାଇଡ୍ରୋକ୍ସିଲେଜ୍ (PAH)ର କାର୍ଯ୍ୟକଳାପକୁ ଉନ୍ନତ କରିଥାଏ, ଯାହା ଫଳରେ ଫିନାଇଲଆଲାନିନ ଭାଙ୍ଗିଯାଏ ।^[୨]

୨୦୦୭ ମସିହାରେ ଆମେରିକାରେ,^[୨] ୨୦୦୮ରେ ୟୁରୋପରେ ^[୩] ଏବଂ ୨୦୧୦ରେ କାନାଡାରେ ଚିକିତ୍ସା ପାଇଁ ସାପ୍ରୋପ୍ଟେରିନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ୨୦୧୭ ମସିହାରେ ୬୮କିଲୋଗ୍ରାମ ବିଶିଷ୍ଟ ବ୍ୟକ୍ତିଙ୍କ ପାଇଁ କାନାଡ଼ାରେ ବର୍ଷକୁ ପ୍ରାୟ ୪୮,୦୦୦ରୁ ୧୬୮,୦୦୦ କାନାଡ଼ା ଡଲାର ଖର୍ଚ୍ଚ ହୋଇଥାଏ ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ବାର୍ଷିକ ଖର୍ଚ୍ଚ ୩୮,୦୦୦ରୁ ୧୫୨,୦୦୦ ଡଲାର ଥିବାବେଳେ ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ଏହି ବାବଦ ଖର୍ଚ୍ଚ ପ୍ରାୟ ୨୫,୦୦୦ରୁ, ୧୦୦,୦୦୦ ପାଉଣ୍ଡ ଅଟେ ।^[୭] ^[୮] ଏହା କୁଭାନ୍ ଏବଂ ବାୟୋପ୍ଟେନ ନାମରେ ବିକ୍ରି ହୁଏ । ^[୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Sapropterin (Kuvan) Use During Pregnancy". Drugs.com. 17 May 2019. Archived from the original on 29 October 2020. Retrieved 4 March 2020.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ ^୨.୭ "Sapropterin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 August 2021. Retrieved 10 October 2021.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "Kuvan". Archived from the original on 14 August 2020. Retrieved 10 October 2021.
↑ "Sapropterin (Kuvan) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 10 October 2021.
↑ Patient Group Input Submissions: sapropterin dihydrochloride (Kuvan) for Phenylketonuria (PKU). Canadian Agency for Drugs and Technologies in Health. 2017. Archived from the original on 12 October 2021. Retrieved 10 October 2021.
↑ "Sapropterin dihydrochloride (Kuvan)" (PDF). CADTH. September 2017. Archived (PDF) from the original on 11 February 2020. Retrieved 10 October 2021.
↑ "Sapropterin Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 August 2021. Retrieved 10 October 2021.
↑ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1139. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Australian Public Assessment Report for Sapropterin dihydrochloride" (PDF). Archived (PDF) from the original on 12 October 2021. Retrieved 10 October 2021.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ "Sapropterin (Kuvan) Use During Pregnancy". Drugs.com. 17 May 2019. Archived from the original on 29 October 2020. Retrieved 4 March 2020.

[AHFS2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ ^୨.୭ "Sapropterin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 August 2021. Retrieved 10 October 2021.

[EPAR2021-3] ୩.୦ ^୩.୧ ^୩.୨ "Kuvan". Archived from the original on 14 August 2020. Retrieved 10 October 2021.

[Preg2021-4] "Sapropterin (Kuvan) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 10 October 2021.

[5] Patient Group Input Submissions: sapropterin dihydrochloride (Kuvan) for Phenylketonuria (PKU). Canadian Agency for Drugs and Technologies in Health. 2017. Archived from the original on 12 October 2021. Retrieved 10 October 2021.

[CADTH2017-6] "Sapropterin dihydrochloride (Kuvan)" (PDF). CADTH. September 2017. Archived (PDF) from the original on 11 February 2020. Retrieved 10 October 2021.

[7] "Sapropterin Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 August 2021. Retrieved 10 October 2021.

[BNF80-8] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1139. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[9] "Australian Public Assessment Report for Sapropterin dihydrochloride" (PDF). Archived (PDF) from the original on 12 October 2021. Retrieved 10 October 2021.

[୧]

[୨]

[୩]

[୪]

[୫]

[୬]

[୭]

[୮]

[୯]