ଡିଡାନୋସିନ

ଡିଡାନୋସିନ
Clinical data
Pronunciation	dye dan' oh seen
Trade names	Videx
Synonyms	2′,3′-dideoxyinosine
AHFS/Drugs.com	monograph
MedlinePlus	a691006
Pregnancy; category	AU: B2 ;
Routes of; administration	By mouth
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	30 to 54%
Protein binding	Less than 5%
Elimination half-life	1.5 hours
Excretion	Kidney
Identifiers
	IUPAC name 9-((2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one;
ECHA InfoCard	100.129.182
Chemical and physical data
Formula	C10H12N4O3
Molar mass	୨୩୬.୨୩ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C3/N=C\Nc1c3ncn1[C@@H]2O[C@@H](CC2)CO;
	InChI InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1 ; Key:BXZVVICBKDXVGW-NKWVEPMBSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Didanosine

ଡିଡାନୋସିନ (ଇଂରାଜୀ ଭାଷାରେ Didanosine/ ddI ), ଭିଡେକ୍ସ ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏଚ୍.ଆଇ.ଭି/ଏଡସ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ।^[୨] ଏହାକୁ ଅନ୍ୟ ଏଚ.ଆଇ.ଭି ଔଷଧ ସହିତ ଦିଆଯାଏ। ।^[୨] ଏହା ପ୍ରଥମ ଧାଡ଼ିର ଚିକିତ୍ସା ନୁହେଁ ।^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ପେରିଫେରାଲ୍ ନ୍ୟୁରୋପାଥି, ଅଇ, ମୁଣ୍ଡବିନ୍ଧା ଏବଂ ରାସ ହୋଇପାରେ ।^[୧] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଗ୍ନାଶୟ ପ୍ରଦାହ, ଯକୃତ ସମସ୍ୟା, ଲାକ୍ଟିକ୍ ଏସିଡୋସିସ୍ ଏବଂ ଅପ୍ଟିକ୍ ନ୍ୟୁରାଇଟିସ୍ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ସାଧାରଣତଃ ଏହା ଅପେକ୍ଷା ଅନ୍ୟ ଔଷଧକୁ ଅଧିକ ପସନ୍ଦ କରାଯାଏ ।^[୩] ଏହା ଏକ ନ୍ୟୁକ୍ଲିଓସାଇଡ ରିଭର୍ସ-ଟ୍ରାନ୍ସକ୍ରିପଟେଜ ଇନହିବିଟର (NRTI) ।^[୨]

ଡିଡାନୋସିନ ପ୍ରଥମେ ୧୯୭୫ ମସିହାରେ ବର୍ଣ୍ଣନା କରାଯାଇଥିଲା ଏବଂ ୧୯୯୧ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ୪୦୦ ମିଗ୍ରା ବିଶିଷ୍ଟ ୩୦ଟି ବଟିକାର ମୂଲ୍ୟ ପ୍ରାୟ ୨୭୦ ଡଲାର୍ ଥିଲା ।^[୫] ପୂର୍ବରୁ ସାଧାରଣ ଭାବରେ ବ୍ୟବହୃତ ହେଉଥିବାବେଳେ, ଏହା ଅପେକ୍ଷା ଭଲ ସହନଶୀଳ ଔଷଧ ମିଳିବା ହେତୁ ଏହା କ୍ୱଚିତ୍ ବ୍ୟବହୃତ ହେଉଛି ।^[୬]

ଆଧାର

1 2 3 "DailyMed - DIDANOSINE capsule, delayed release pellets". dailymed.nlm.nih.gov. Archived from the original on 11 January 2022. Retrieved 24 December 2021.
1 2 3 4 "Didanosine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 November 2021. Retrieved 24 December 2021.
1 2 "Didanosine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 November 2021. Retrieved 24 December 2021.
↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 505. ISBN 9783527607495. Archived from the original on 2021-02-07. Retrieved 2021-04-27.
↑ "Didanosine Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 24 December 2021.
↑ "Didanosine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 January 2022. Retrieved 24 December 2021.

[PI2021-1] 1 2 3 "DailyMed - DIDANOSINE capsule, delayed release pellets". dailymed.nlm.nih.gov. Archived from the original on 11 January 2022. Retrieved 24 December 2021.

[AHFS2021-2] 1 2 3 4 "Didanosine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 November 2021. Retrieved 24 December 2021.

[Preg2021-3] 1 2 "Didanosine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 November 2021. Retrieved 24 December 2021.

[4] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 505. ISBN 9783527607495. Archived from the original on 2021-02-07. Retrieved 2021-04-27.

[5] "Didanosine Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 24 December 2021.

[Liv2021-6] "Didanosine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 January 2022. Retrieved 24 December 2021.

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