କ୍ଲୋରଫେନାମାଇନ

କ୍ଲୋରଫେନାମାଇନ
Clinical data
Pronunciation	klor" fen ir' a meen
Trade names	Chlor-Trimeton; Piriton
Synonyms	Chlorpheniramine maleate
AHFS/Drugs.com	monograph
MedlinePlus	a682543
Pregnancy; category	AU: A ; US: B (No risk in non-human studies) ;
Routes of; administration	By mouth, IV, IM, SC
Legal status
Legal status	AU: S3 (Pharmacist only) ; UK: Pharmacy medicines ; US: OTC ;
Pharmacokinetic data
Bioavailability	25 to 50%
Protein binding	72%
Metabolism	Liver (CYP2D6)
Onset of action	With 6 hr
Elimination half-life	13.9–43.4 hours
Duration of action	~24 hr
Excretion	Kidney
Identifiers
	IUPAC name 3-(4-Chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine;
ECHA InfoCard	100.004.596
Chemical and physical data
Formula	C16H19ClN2
Molar mass	୨୭୪.୭୯ g·mol−1
3D model (JSmol)	Interactive image;
Solubility in water	0.55 g/100 mL, liquid mg/mL (20 °C)
	SMILES Clc1ccc(cc1)C(c2ncccc2)CCN(C)C;
	InChI InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3 ; Key:SOYKEARSMXGVTM-UHFFFAOYSA-N ;
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କ୍ଲୋରଫେନାମାଇନ ( ସିପି, ସିପିଏମ୍ ), ଯାହା କ୍ଲୋରଫେନିରାମାଇନ୍ ଭାବରେ ମଧ୍ୟ ଜଣାଶୁଣା, ଏକ ଆଣ୍ଟିହିସ୍ଟାମିନ ଯାହା ଆଲର୍ଜିକ ନାକପ୍ରଦାହ ପରି ଲକ୍ଷଣର ଚିକିତ୍ସା କରିବା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୨] ଏହି ଔଷଧ 6 ଘଣ୍ଟା ମଧ୍ୟରେ କାର୍ଯ୍ୟକାରୀ ହୁଏ ଏବଂ ପ୍ରାୟ ଏକ ଦିନ ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ । ^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରା, ଅସ୍ଥିରତା ଏବଂ ଦୁର୍ବଳତା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶୁଖିଲା ପାଟି ଏବଂ ଚକ୍କର ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୨] ଗର୍ଭଧାରଣର ପ୍ରଥମ ଦୁଇ ତ୍ରୈମାସିକରେ କ୍ଷତି ହେବାର କୌଣସି ପ୍ରମାଣ ନାହିଁ; ଯଦିଓ ପରବର୍ତ୍ତୀ ଗର୍ଭଧାରଣ ସମୟରେ ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୪] ^[୨] ଏହା ପ୍ରଥମ ପିଢ଼ିର ଆଣ୍ଟିହାଇଷ୍ଟାମାଇନ୍ ଏବଂ ଏଚ୧ (H1।) ରିସେପ୍ଟରକୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୨]

କ୍ଲୋରଫେନାମାଇନ ପ୍ୟାଟେଣ୍ଟ୍ ହୋଇଥିଲା ୧୯୪୮ ମସିହାରେ ଏବଂ ୧୯୪୯ ମସିହାରେ ଡାକ୍ତରୀ ବ୍ୟବହାରରେ ଆସିଥିଲା ।^[୫] ଏହା ଏକ ଜେନେରିକ୍ ଔଷଧ ଏବଂ ବିନା ପ୍ରେସକ୍ରିପସନରେ ଉପଲବ୍ଧ ।^[୨] ^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ୪ ମିଗ୍ରାର ୨୮ ଟାବଲେଟର ମୂଲ୍ୟ 2021 ସୁଦ୍ଧା ପ୍ରାୟ £୨ ଅଟେ। ^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶି ପ୍ରାୟ 0.୮୦ ଡଲାର ଅଟେ। ^[୭] ଏହା ଅନେକ ମିଶ୍ରଣ ଉତ୍ପାଦରେ ଉପସ୍ଥିତ ଏବଂ ସାଧାରଣ ଭାବରେ ବ୍ୟବହୃତ ହୁଏ । ^[୧]

ଆଧାର

1 2 3 "Brompheniramine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 January 2022. Retrieved 4 January 2022.
1 2 3 4 5 6 7 8 9 10 "Chlorpheniramine Maleate, Dexchlorpheniramine Maleate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 15 July 2019. Retrieved 15 July 2019.
↑ Yasuda SU, Wellstein A, Likhari P, Barbey JT, Woosley RL (1995). "Chlorpheniramine plasma concentration and histamine H1-receptor occupancy". Clin. Pharmacol. Ther. 58 (2): 210–20. doi:10.1016/0009-9236(95)90199-X. PMID 7648771.
1 2 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 299. ISBN 978-0857114105.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 546. ISBN 9783527607495. Archived from the original on 11 December 2019. Retrieved 3 March 2019.
↑ "Over-the-Counter Medicines for Allergies". HealthLink BC (in ଇଂରାଜୀ). Archived from the original on 15 July 2019. Retrieved 15 July 2019.
↑ "Compare Chlorpheniramine Prices - GoodRx". GoodRx. Retrieved 4 January 2022.

[Liv2022-1] 1 2 3 "Brompheniramine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 January 2022. Retrieved 4 January 2022.

[AHFS2019-2] 1 2 3 4 5 6 7 8 9 10 "Chlorpheniramine Maleate, Dexchlorpheniramine Maleate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 15 July 2019. Retrieved 15 July 2019.

[pmid7648771-3] Yasuda SU, Wellstein A, Likhari P, Barbey JT, Woosley RL (1995). "Chlorpheniramine plasma concentration and histamine H1-receptor occupancy". Clin. Pharmacol. Ther. 58 (2): 210–20. doi:10.1016/0009-9236(95)90199-X. PMID 7648771.

[BNF81-4] 1 2 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 299. ISBN 978-0857114105.

[Fis2006-5] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 546. ISBN 9783527607495. Archived from the original on 11 December 2019. Retrieved 3 March 2019.

[6] "Over-the-Counter Medicines for Allergies". HealthLink BC (in ଇଂରାଜୀ). Archived from the original on 15 July 2019. Retrieved 15 July 2019.

[7] "Compare Chlorpheniramine Prices - GoodRx". GoodRx. Retrieved 4 January 2022.

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