ଏଭେରୋଲିମସ

ଏଭେରୋଲିମସ
Clinical data
Pronunciation	Everolimus /ˌɛvəˈroʊləməs/
Trade names	Afinitor, Zortress, others
Synonyms	42-O-(2-hydroxyethyl)rapamycin, RAD001
AHFS/Drugs.com	monograph
MedlinePlus	a609032
data	EU EMA: yes; US DailyMed: Everolimus;
Pregnancy; category	AU: C ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Elimination half-life	~30 hours
Identifiers
	IUPAC name Dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0 hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone;
ECHA InfoCard	100.149.896
Chemical and physical data
Formula	C53H83NO14
Molar mass	୯୫୮.୨୪ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OCCO[C@@H]1CC[C@H](C[C@H]1OC)C[C@@H](C)[C@@H]4CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(/C)[C@@H](OC)C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N3CCCC[C@H]3C(=O)O4;
	InChI InChI=1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1 ; Key:HKVAMNSJSFKALM-GKUWKFKPSA-N ;
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ଏଭେରୋଲିମସ ହେଉଛି ଏକ ଔଷଧ ଯାହା କେତେକ ପ୍ରକାରର କର୍କଟ ରୋଗର ଚିକିତ୍ସା ପାଇଁ କରାଯାଉଥିବା ଅଙ୍ଗ ପ୍ରତିରୋପଣ ପରେ ପ୍ରତ୍ୟାଖ୍ୟାନ‌କୁ ରୋକିବା ପାଇଁ ବ୍ୟବ‌ହାର କରାଯାଏ ।^[୩] ବୃକ୍‌କ, ହୃତ୍‌ପିଣ୍ଡ ଓ ଯକୃତ ପ୍ରତିରୋପଣ ପରେ ବିଶେଷତଃ ଏହା ଦିଆଯାଏ ।^[୪] ଏହା ସ୍ତନ ଏବଂ ନ୍ୟୁରୋଏଣ୍ଡୋକ୍ରାଇନ ଅର୍ବୁଦ ପାଇଁ ମଧ୍ୟ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୫] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପାଟି ପ୍ରଦାହ, ଶ୍ୱାସନଳୀ ସଂକ୍ରମଣ, ଥକ୍କା, ବାନ୍ତି ଏବଂ ତରଳ ଝାଡ଼ା ହୋଇପାରେ ।^[୩] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କେଶ ଝଡ଼ିବା, ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତ କଣିକା, ରକ୍ତସ୍ରାବ, ବୃକ୍‌କ ସମସ୍ୟା, ରକ୍ତ ଜମାଟ ବାନ୍ଧିବା ଏବଂ ହୃଦ୍‌ପାତ ହୋଇପାରେ ।^[୪] ସମ୍ଭବତଃ ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ^[୬] ଏହା ସିରୋଲିମସର ଏକ ଉତ୍ପାଦନ ଏବଂ ସମାନ ଭାବରେ କାର୍ଯ୍ୟ କରେ; ରାପାମାଇସିନର (mTOR) ସ୍ତନ୍ୟପାୟୀ ଲକ୍ଷ୍ୟକୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୫] ^[୭]

୨୦୦୯ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଏଭେରୋଲିମସ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୩] ^[୫] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୪] ଏହା ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଜରୁରୀ ଔଷଧ ତାଲିକାରେ ଅଛି | ^[୮] ଯୁକ୍ତରାଜ୍ୟରେ ପ୍ରତିରୋପଣ ପରବର୍ତ୍ତୀ ଏକ ମାସର ଚିକିତ୍ସାର ଖର୍ଚ୍ଚ ପ୍ରାୟ ୪୫୦ ପାଉଣ୍ଡ ଥିବାବେଳେ କେତେକ ପ୍ରକାରର କର୍କଟ ରୋଗ ପାଇଁ ୨୦୨୦ ସୁଦ୍ଧା ୨,୯୦୦ ପାଉଣ୍ଡ ହୋଇପାରେ ।^[୪] ^[୯] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ଖର୍ଚ୍ଚ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୪୫୦ ଡଲାର ଥିଲା । ୨୦୨୧ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ଏକ ଜେନେରିକ୍ ସଂସ୍କରଣ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୧୦]

ଆଧାର

↑ ^୧.୦ ^୧.୧ Use During Pregnancy and Breastfeeding
↑ Formica RN, Lorber KM, Friedman AL, Bia MJ, Lakkis F, Smith JD, Lorber MI (March 2004). "The evolving experience using everolimus in clinical transplantation". Transplantation Proceedings. 36 (2 Suppl): 495S–499S. doi:10.1016/j.transproceed.2004.01.015. PMID 15041395.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Everolimus Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 April 2021. Retrieved 23 July 2021.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1034. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ ^୫.୦ ^୫.୧ ^୫.୨ "Afinitor". Archived from the original on 8 April 2021. Retrieved 23 July 2021.
↑ "Everolimus Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 April 2021. Retrieved 23 July 2021.
↑ Wheeler, Derek S.; Wong, Hector R. (2007). Pediatric Critical Care Medicine: Basic Science And Clinical Evidence (in ଇଂରାଜୀ). Springer Science & Business Media. p. 1391. ISBN 978-1-84628-463-2. Archived from the original on 2021-08-28. Retrieved 2021-07-23.
↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
↑ "Everolimus Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 23 July 2021.
↑ Research, Center for Drug Evaluation and (10 February 2022). "2021 First Generic Drug Approvals". FDA (in ଇଂରାଜୀ). Archived from the original on 21 June 2022. Retrieved 22 October 2022.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ Use During Pregnancy and Breastfeeding

[2] Formica RN, Lorber KM, Friedman AL, Bia MJ, Lakkis F, Smith JD, Lorber MI (March 2004). "The evolving experience using everolimus in clinical transplantation". Transplantation Proceedings. 36 (2 Suppl): 495S–499S. doi:10.1016/j.transproceed.2004.01.015. PMID 15041395.

[AHFS2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Everolimus Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 April 2021. Retrieved 23 July 2021.

[BNF80-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1034. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[EMA2021-5] ୫.୦ ^୫.୧ ^୫.୨ "Afinitor". Archived from the original on 8 April 2021. Retrieved 23 July 2021.

[Preg2021-6] "Everolimus Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 April 2021. Retrieved 23 July 2021.

[7] Wheeler, Derek S.; Wong, Hector R. (2007). Pediatric Critical Care Medicine: Basic Science And Clinical Evidence (in ଇଂରାଜୀ). Springer Science & Business Media. p. 1391. ISBN 978-1-84628-463-2. Archived from the original on 2021-08-28. Retrieved 2021-07-23.

[WHO22nd-8] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[GX2021-9] "Everolimus Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 23 July 2021.

[10] Research, Center for Drug Evaluation and (10 February 2022). "2021 First Generic Drug Approvals". FDA (in ଇଂରାଜୀ). Archived from the original on 21 June 2022. Retrieved 22 October 2022.

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