ଆକ୍ସିଟିନିବ

ଆକ୍ସିଟିନିବ
Clinical data
Trade names	Inlyta, Axinix
Synonyms	AG013736
AHFS/Drugs.com	monograph
MedlinePlus	a612017
data	EU EMA: yes; US DailyMed: Axitinib;
Pregnancy; category	AU: D ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	58%
Protein binding	>99%
Metabolism	Liver (mostly CYP3A4/CYP3A5-mediated but with some contributions from CYP1A2, CYP2C19, UGT1A1)
Elimination half-life	2.5-6.1 hours
Excretion	Feces (41%; 12% as unchanged drug), urine (23%)
Identifiers
	IUPAC name N-Methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide;
ECHA InfoCard	100.166.384
Chemical and physical data
Formula	C22H18N4OS
Molar mass	୩୮୬.୪୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CNC(=O)c1ccccc1Sc4ccc3c(C=Cc2ccccn2)n[nH]c3c4;
	InChI InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+ ; Key:RITAVMQDGBJQJZ-FMIVXFBMSA-N ;
(verify)

ଆକ୍ସିଟିନିବ, ବେପାର ନାମ ଇନଲିଟା, ବୃକ୍‌କୀୟ ଜୀବକୋଷ କର୍କଟ (RCC)ର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୩] ଏହା ଏକାକୀ କିମ୍ବା ଆଭେଲୁମାବ କିମ୍ବା ପେମ୍ବ୍ରୋଲିଜୁମାବ ସହିତ ଅଗ୍ରବର୍ତ୍ତୀ ରୋଗରେ ବ୍ୟବହୃତ ହୁଏ । ^[୩] ସୋରାଫେନିବ ଗ୍ରହଣ କରୁଥିବା ବ୍ୟକ୍ତିଙ୍କ କ୍ଷେତ୍ରରେ ଏହା ୪.୭ ମାସରୁ ଏହା ୬.୭ ମାସ ପର୍ଯ୍ୟନ୍ତ ଖରାପ ହେବାକୁ ବିଳମ୍ବିତ କରେ । ^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ଉଚ୍ଚ ରକ୍ତଚାପ, ଥକ୍କା, ବାନ୍ତି, ଓଜନ ହ୍ରାସ, ଦୁର୍ବଳତା ଏବଂ କୋଷ୍ଠକାଠିନ୍ୟ ହୋଇପାରେ । ^[୩] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରକ୍ତ ଜମାଟ ବାନ୍ଧିବା, ରକ୍ତସ୍ରାବ, ହୃଦଘାତ, ଜଠରାନ୍ତ୍ର ଛିଦ୍ର, କମ୍ ଥାଇରଏଡ୍, ଖରାପ କ୍ଷତ ଆରୋଗ୍ୟ, ଯକୃତ ସମସ୍ୟା ଏବଂ ରିଭର୍ସିବଲ ପୋଷ୍ଟିରିଅର୍ ଲ୍ୟୁକୋଏନ୍‌ସ ଫାଲୋପାଥି ସିଣ୍ଡ୍ରୋମ (RPLS) ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ। ^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ | ^[୩] ଏହା ଏକ ଟାଇରୋସିନ୍ କାଇନେଜ ଇନହିବିଟର ଯାହା ଭାସ୍କୁଲାର ଏଣ୍ଡୋଥେଲିଆଲ୍ ବୃଦ୍ଧି କାରକ (VEGF)କୁ ଅବରୋଧ କରିଥାଏ | ^[୫]

୨୦୧୨ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଆକ୍ସିଟିନିବ ଅନୁମୋଦିତ ହୋଇଥିଲା । ^[୪] ^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ମୂଲ୍ୟ ପ୍ରାୟ ୧୭,୩୦୦ ଡଲାର ଅଟେ । ^[୬]

ଆଧାର

↑ "Inlyta- axitinib tablet, film coated". DailyMed. Pfizer Inc. Archived from the original on 27 November 2019. Retrieved 25 January 2014.
1 2 3 4 5 "Inlyta (axitinib) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 5 July 2018. Retrieved 25 January 2014.
1 2 3 4 5 6 7 "DailyMed - INLYTA- axitinib tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 27 June 2021. Retrieved 17 January 2022.
1 2 "Inlyta". Archived from the original on 8 October 2021. Retrieved 17 January 2022.
↑ "Axitinib". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 6 May 2021. Retrieved 17 January 2022.
↑ "Inlyta Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 19 April 2021. Retrieved 17 January 2022.

[Inlyta_FDA_label-1] "Inlyta- axitinib tablet, film coated". DailyMed. Pfizer Inc. Archived from the original on 27 November 2019. Retrieved 25 January 2014.

[MSR-2] 1 2 3 4 5 "Inlyta (axitinib) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 5 July 2018. Retrieved 25 January 2014.

[PI2022-3] 1 2 3 4 5 6 7 "DailyMed - INLYTA- axitinib tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 27 June 2021. Retrieved 17 January 2022.

[EPAR2022-4] 1 2 "Inlyta". Archived from the original on 8 October 2021. Retrieved 17 January 2022.

[Liv2022-5] "Axitinib". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 6 May 2021. Retrieved 17 January 2022.

[6] "Inlyta Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 19 April 2021. Retrieved 17 January 2022.

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