ଆକାଲାବ୍ରୁଟିନିବ

ଆକାଲାବ୍ରୁଟିନିବ
Clinical data
Trade names	Calquence
Synonyms	ACP-196
AHFS/Drugs.com	monograph
MedlinePlus	a618004
data	US DailyMed: Acalabrutinib;
Pregnancy; category	AU: C ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Identifiers
	IUPAC name 4-{8-Amino-3-[(2S)-1-(2-butynoyl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl}-N-(2-pyridinyl)benzamide;
ECHA InfoCard	100.247.121
Chemical and physical data
Formula	C26H23N7O2
Molar mass	୪୬୫.୫୨ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC#CC(=O)N1CCC[C@H]1c2nc(c3n2ccnc3N)c4ccc(cc4)C(=O)Nc5ccccn5;
	InChI InChI=1S/C26H23N7O2/c1-2-6-21(34)32-15-5-7-19(32)25-31-22(23-24(27)29-14-16-33(23)25)17-9-11-18(12-10-17)26(35)30-20-8-3-4-13-28-20/h3-4,8-14,16,19H,5,7,15H2,1H3,(H2,27,29)(H,28,30,35)/t19-/m0/s1; Key:WDENQIQQYWYTPO-IBGZPJMESA-N;

ଆକାଲାବ୍ରୁଟିନିବ, ବେପାର ନାମ କାଲକେନ୍ସ, ଏକ ଔଷଧ ଯାହା ମାଣ୍ଟ୍ଲ ସେଲ ଲିମ୍ଫୋମା (MCL) ଏବଂ କ୍ରୋନିକ୍ ଲିମ୍ଫୋସାଇଟିକ୍ ଲ୍ୟୁକେମିଆ (CLL)ର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୪] ^[୫] ଶେଷୋକ୍ତ (CLL) ରୋଗ ପାଇଁ ଏହା ପ୍ରାରମ୍ଭରୁ କିମ୍ବା ଅନ୍ୟ ଚିକିତ୍ସାରେ ବିଫଳ ହୋଇଥିବା ଲୋକମାନଙ୍କ ପାଇଁ ବ୍ୟବହୃତ ହୋଇପାରେ । ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୬]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା, ଥକ୍କା ଅନୁଭବ, କମ ଲୋହିତ ରକ୍ତ କଣିକା, କମ୍ ପ୍ଲାଲେଟ୍ ଏବଂ କମ ଶ୍ୱେତ ରକ୍ତ କଣିକା ହୋଇପାରେ । ^[୪] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସଂକ୍ରମଣ, ରକ୍ତସ୍ରାବ, ପରବର୍ତ୍ତୀ କର୍କଟ ଏବଂ ଆଟ୍ରିଆଲ୍ ଫିବ୍ରିଲେସନ୍ ହୋଇପାରେ । ^[୬] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ । ^[୩] ଏହା ଏକ ବ୍ରୁଟନ୍ ଟାଇରୋସିନ୍ କାଇନେଜ ଇନହିବିଟର, ଯାହା କର୍କଟ ରୋଗର କୋଷଗୁଡ଼ିକର ନିର୍ମାଣକୁ ମନ୍ଥର କରିଥାଏ । ^[୫]

୨୦୧୭ରେ ଆମେରିକାରେ ଏବଂ ୨୦୨୦ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଆକାଲାବ୍ରୁଟିନିବ ଅନୁମୋଦିତ ହୋଇଥିଲା । ^[୫] ^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ରେ ଦୋତିଏ ମାସର ଏହି ଔଷଧ ଖର୍ଚ୍ଚ ୫୧୦୦ ପାଉଣ୍ଡ ଥିଲା ।^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ପ୍ରାୟ ୧୫,୦୦୦ ଡଲାର ଅଟେ । ^[୮]

ଆଧାର[ସମ୍ପାଦନା]

↑ ^୧.୦ ^୧.୧ "Acalabrutinib (Calquence) Use During Pregnancy". Drugs.com. 23 October 2019. Archived from the original on 28 March 2020. Retrieved 28 March 2020.
↑ ^୨.୦ ^୨.୧ "Calquence EPAR". European Medicines Agency. 20 July 2020. Archived from the original on 17 November 2020. Retrieved 11 November 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ ^୩.୦ ^୩.୧ "Calquence- acalabrutinib capsule, gelatin coated". DailyMed. 22 November 2019. Archived from the original on 23 March 2021. Retrieved 11 November 2020.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "Acalabrutinib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 November 2019. Retrieved 16 March 2019.
↑ ^୫.୦ ^୫.୧ ^୫.୨ "Calquence EPAR". European Medicines Agency. 20 July 2020. Archived from the original on 17 November 2020. Retrieved 11 November 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ ^୬.୦ ^୬.୧ "Calquence- acalabrutinib capsule, gelatin coated". DailyMed. 22 November 2019. Archived from the original on 23 March 2021. Retrieved 11 November 2020.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1010. ISBN 978-0857114105.
↑ "Calquence Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 18 January 2021. Retrieved 13 January 2022.

[autogen1-1] ୧.୦ ^୧.୧ "Acalabrutinib (Calquence) Use During Pregnancy". Drugs.com. 23 October 2019. Archived from the original on 28 March 2020. Retrieved 28 March 2020.

[autogen2-2] ୨.୦ ^୨.୧ "Calquence EPAR". European Medicines Agency. 20 July 2020. Archived from the original on 17 November 2020. Retrieved 11 November 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[autogen3-3] ୩.୦ ^୩.୧ "Calquence- acalabrutinib capsule, gelatin coated". DailyMed. 22 November 2019. Archived from the original on 23 March 2021. Retrieved 11 November 2020.

[AHFS2019-4] ୪.୦ ^୪.୧ ^୪.୨ "Acalabrutinib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 November 2019. Retrieved 16 March 2019.

[EPAR2022-5] ୫.୦ ^୫.୧ ^୫.୨ "Calquence EPAR". European Medicines Agency. 20 July 2020. Archived from the original on 17 November 2020. Retrieved 11 November 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[PI2022-6] ୬.୦ ^୬.୧ "Calquence- acalabrutinib capsule, gelatin coated". DailyMed. 22 November 2019. Archived from the original on 23 March 2021. Retrieved 11 November 2020.

[BNF81-7] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1010. ISBN 978-0857114105.

[8] "Calquence Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 18 January 2021. Retrieved 13 January 2022.

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