ଏର୍ଟୁଗ୍ଲିଫ୍ଲୋଜିନ

ଏର୍ଟୁଗ୍ଲିଫ୍ଲୋଜିନ
Clinical data
Trade names	Steglatro
Synonyms	PF-04971729, ertugliflozin l-pyroglutamic acid
AHFS/Drugs.com	monograph
data	US DailyMed: Ertugliflozin;
Pregnancy; category	AU: D ; ;
Routes of; administration	By mouth
Legal status
Legal status	CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	~100%
Protein binding	93.6%
Metabolism	UGT1A9, UGT2B7
Metabolites	Glucuronides
Elimination half-life	~17 hours
Excretion	41% faeces, 50% urine
Identifiers
	IUPAC name (1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol;
ECHA InfoCard	100.237.989
Chemical and physical data
Formula	C22H25ClO7
Molar mass	୪୩୬.୮୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOc1ccc(cc1)Cc2cc(ccc2Cl)[C@@]34[C@@H]([C@H]([C@@H]([C@@](O3)(CO4)CO)O)O)O;
	InChI InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27)18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20+,21-,22-/m0/s1; Key:MCIACXAZCBVDEE-CUUWFGFTSA-N;

ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Ertugliflozin

ଏର୍ଟୁଗ୍ଲିଫ୍ଲୋଜିନ (ଇଂରାଜୀ ଭାଷାରେ Ertugliflozin), ଷ୍ଟେଗ୍ଲାଟ୍ରୋ ବ୍ରାଣ୍ଡ ଏହାର ଏକ ବେପାର ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଟାଇପ୍-୨ ମଧୁମେହର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ।^[୩] ^[୨] ଏହା ଉପ‌ଯୁକ୍ତ ଖାଦ୍ୟ ଏବଂ ବ୍ୟାୟାମ ସହିତ ଏକତ୍ର ବ୍ୟବହୃତ ହୁଏ ।^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩] ଟାଇପ୍-୧ ମଧୁମେହ ରୋଗୀଙ୍କ କ୍ଷେତ୍ରରେ ଏହା ବ୍ୟବହାର କରାଯିବା ଉଚିତ୍ ନୁହେଁ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଯୋନିପଥର କବକ ସଂକ୍ରମଣ ଏବଂ ମହିଳା ପ୍ରଜନନ ପ୍ରଣାଳୀର ଅନ୍ୟାନ୍ୟ ସଂକ୍ରମଣ ଅନ୍ତର୍ଭୁକ୍ତ ।^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଡାଏବେଟିକ କିଟୋଏସିଡୋସିସ (DKA), ଅଙ୍ଗପ୍ରତ୍ୟଙ୍ଗ ଅଙ୍ଗଛେଦନ ଏବଂ ଫୋର୍ନିୟର ଗ୍ୟାଙ୍ଗ୍ରିନ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୨] ^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କରିବାକୁ ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୨] ଏହା ଏକ ସୋଡ଼ିଅମ୍ ଗ୍ଲୁକୋଜ୍ କୋଟ୍ରାନ୍ସପୋର୍ଟର୍୨ (SGLT2) ଇନହିବିଟର ଯାହା ମୂତ୍ରରେ ବୋହିଯାଉଥିବା ଶର୍କରାରେ ପରିମାଣକୁ ବଢ଼େଇଥାଏ |^[୩] ^[୨]

୨୦୧୭ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୧୮ରେ ୟୁରୋପରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଏର୍ଟୁଗ୍ଲିଫୋଜିନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ^[୨] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ୪ ସପ୍ତାହର ଔଷଧ ଖର୍ଚ୍ଚ ପ୍ରାୟ ୩୦ ପାଉଣ୍ଡ ଥିଲା ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ହେଉଛି ୨୮୦ ଡଲାର ।^[୬]

ଆଧାର

↑ Australian Public Assessment Report for Ertugliflozin, Ertugliflozin / Sitagliptin, Ertugliflozin / Metformin (Report). https://www.tga.gov.au/sites/default/files/auspar-ertugliflozin-ertugliflozine-sitagliptin-ertugliflozin-metformin-190205.pdf. Retrieved 30 September 2021.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Steglatro EPAR". European Medicines Agency (EMA). Archived from the original on 8 October 2020. Retrieved 24 September 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ "Steglatro- ertugliflozin tablet, film coated". DailyMed. 30 January 2020. Archived from the original on 4 August 2020. Retrieved 24 September 2020.
↑ "Ertugliflozin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 January 2021. Retrieved 16 December 2021.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 749. ISBN 978-0857114105.
↑ "Steglatro Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 16 December 2021.

[Steglatro_AusPAR-1] Australian Public Assessment Report for Ertugliflozin, Ertugliflozin / Sitagliptin, Ertugliflozin / Metformin (Report). https://www.tga.gov.au/sites/default/files/auspar-ertugliflozin-ertugliflozine-sitagliptin-ertugliflozin-metformin-190205.pdf. Retrieved 30 September 2021.

[EPAR2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Steglatro EPAR". European Medicines Agency (EMA). Archived from the original on 8 October 2020. Retrieved 24 September 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[PI2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ "Steglatro- ertugliflozin tablet, film coated". DailyMed. 30 January 2020. Archived from the original on 4 August 2020. Retrieved 24 September 2020.

[AHFS2021-4] "Ertugliflozin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 January 2021. Retrieved 16 December 2021.

[BNF81-5] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 749. ISBN 978-0857114105.

[6] "Steglatro Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 16 December 2021.

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