କ୍ୱିନିଡାଇନ

<span title="International nonproprietary name (INN): <nowiki>Mr. Ibrahem/Quinidine</nowiki>">Mr. Ibrahem/Quinidine
Clinical data
Trade names	Quinaglute, Quinidex
Other names	(2-Ethenyl-4-azabicyclo[2.2.2]oct-5-yl)-(6-methoxyquinolin-4-yl)-methanol
AHFS/Drugs.com	Monograph
Pregnancy; ; category	<abbr class="country-name" title="<nowiki>Australia</nowiki>">AU: C;
Routes of<br><br>administration	By mouth, intravenous
Drug class	class I antiarrhythmic agent (Ia)
Legal status
Legal status	<abbr class="country-name" title="<nowiki>Australia</nowiki>">AU: S4 (Prescription only); <abbr class="country-name" title="<nowiki>Canada</nowiki>">CA: ℞-only; <abbr class="country-name" title="<nowiki>United Kingdom</nowiki>">UK: POM (Prescription only); <abbr class="country-name" title="<nowiki>United States</nowiki>">US: ℞-only;
Pharmacokinetic data
Bioavailability	70–85%
Metabolism	50–90% (by liver)
Elimination <span class="nowrap">half-life</span>	6–8 hours
Excretion	By the liver (20% as unchanged quinidine via urine)
Identifiers
	IUPAC name (S)-(6-Methoxyquinolin-4-yl)[(1S,2R,4S,5R)-5-vinylquinuclidin-2-yl]methanol;
Chemical and physical data
Formula	C20H24N2O2
Molar mass	324.424 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O(c4cc1c(nccc1[C@H](O)[C@@H]2N3CC[C@@H](C2)[C@@H](/C=C)C3)cc4)C;
	InChI InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1 ; Key:LOUPRKONTZGTKE-LHHVKLHASA-N ;
	(what is this?) (verify)

କ୍ୱିନିଡାଇନ ହେଉଛି ଏକ ଔଷଧ ଯାହା ସୁପ୍ରାଭେଣ୍ଟ୍ରିକୁଲାର ଟାକିକାର୍ଡିଆ, ଅନିୟମିତ ହୃତ୍‌ ସ୍ପନ୍ଦନ ଏବଂ ମ୍ୟାଲେରିଆର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ଜୀବନ ପ୍ରତି ବିପଦ ନ ଥିବା ଆରିଥମିଆରେ ଔଷଧ ଦେଲେ ମୃତ୍ୟୁ ଆଶଙ୍କା ବଢ଼ିଯାଏ ।^[୧] ଏହା ପାଟିରେ ଦିଆଯାଏ କିମ୍ବା ଶିରାରେ ଇଞ୍ଜେକ୍ସନଦ୍ୱାରା ଦିଆଯାଏ ।^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଭାଡ଼ା, ଅଇ ଓ ମୁଣ୍ଡ ହାଲୁକା ଲାଗେ । ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କ୍ୟୁଟି ଲମ୍ବା ହୋଇଯାଏ ଓ ଆଲର୍ଜି ହୋଇପାରେ । ଗର୍ଭାବସ୍ଥାରେ ଏହା ଅପେକ୍ଷାକୃତ ବିପଦମୁକ୍ତ ମନେହୁଏ ।^[୨] ଏହା ଏକ ପ୍ରଥମ ଶ୍ରେଣୀର ଆଣ୍ଟିଆରିଦମିକ ଔଷଧ ଯାହା ହୃତ୍‌ପିଣ୍ଡରେ ବୈଦୁତିକ ଗତି ହାର କମ କରିଦିଏ ।

ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ଔଷଧ ୧୯୫୦ ମସିହାରେ ଡାକ୍ତରୀ ଚିକିତ୍ସା ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା । ୨୦୧୯ ସୁଦ୍ଧା ଯୁକ୍ତରାଷ୍ଟ୍ର ଓ ଯୁକ୍ତରାଜ୍ୟରେ ଏହା ଉପଲବ୍‌ଧ ହୋଇ ନାହିଁ ।^[୩]^[୪] ପ୍ରଥମେ ସିଙ୍କୋନା ବୃକ୍ଷର ଛାଲିରୁ ତିଆରି ହୋଇଥିବା ଏହି ଔଷଧ ହେଉଛି କୁଇନାଇନର ଏକ ସ୍ଟେରିଓଆଇସୋମର ।^[୫]

ଆଧାର[ସମ୍ପାଦନା]

↑ ^୧.୦ ^୧.୧ ^୧.୨ "QuiNIDine Monograph for Professionals". Drugs.com. Archived from the original on 3 June 2021. Retrieved 20 October 2021.
↑ "Quinidine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 20 October 2021.
↑ "CDC: Artesunate Now First-Line Treatment for Severe Malaria in the United States | CDC Online Newsroom | CDC". www.cdc.gov (in ଆମେରିକୀୟ ଇଂରାଜୀ). 28 March 2019. Archived from the original on 1 April 2019. Retrieved 6 April 2019.
↑ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1070. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information". druginfo.nlm.nih.gov (in ଇଂରାଜୀ). Archived from the original on 16 July 2021. Retrieved 20 October 2021.

[AHFS2021-1] ୧.୦ ^୧.୧ ^୧.୨ "QuiNIDine Monograph for Professionals". Drugs.com. Archived from the original on 3 June 2021. Retrieved 20 October 2021.

[2] "Quinidine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 20 October 2021.

[CDC2019-3] "CDC: Artesunate Now First-Line Treatment for Severe Malaria in the United States | CDC Online Newsroom | CDC". www.cdc.gov (in ଆମେରିକୀୟ ଇଂରାଜୀ). 28 March 2019. Archived from the original on 1 April 2019. Retrieved 6 April 2019.

[BNF80-4] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1070. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[5] "Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information". druginfo.nlm.nih.gov (in ଇଂରାଜୀ). Archived from the original on 16 July 2021. Retrieved 20 October 2021.

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