ଫାଇସୋଷ୍ଟିଗମିନ

ଫାଇସୋଷ୍ଟିଗମିନ
Clinical data
Trade names	Antilirium
AHFS/Drugs.com	monograph
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ;
Routes of; administration	intravenous, intramuscular, ophthalmic
ATC code	S01EB05 (WHO) V03AB19;
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Metabolism	Major metabolite: Eseroline
Identifiers
	IUPAC name (3aS,8aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl methylcarbamate;
CAS Number	57-47-6 ;
PubChem CID	5983;
IUPHAR/BPS	6598;
DrugBank	DB00981 ;
ChemSpider	5763 ;
UNII	9U1VM840SP;
KEGG	D00196 ;
ChEBI	CHEBI:27953 ;
ChEMBL	CHEMBL94 ;
ECHA InfoCard	100.000.302
Chemical and physical data
Formula	C15H21N3O2
Molar mass	୨୭୫.୩୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(Oc1cc2c(cc1)N([C@H]3N(CC[C@@]23C)C)C)NC;
	InChI InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1 ; Key:PIJVFDBKTWXHHD-HIFRSBDPSA-N ;
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ଫାଇସୋଷ୍ଟିଗମିନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଆଣ୍ଟିଲିରିୟମ୍, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଆଣ୍ଟିକୋଲିନର୍ଜିକ ପ୍ରଭାବକୁ ଓଲଟାଇବା ପାଇଁ ଏବଂ ଫ୍ରେଡରିକ ଆଟାକ୍ସିଆ ସହିତ ବଂଶଗତ ଆଟାକ୍ସିଆର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ଏହା ସାଧାରଣତଃ ଶିରା କିମ୍ବା ମାଂସପେଶୀରେ ଇଞ୍ଜେକ୍ସନ ଆକାରରେ ଦିଆଯାଏ ।^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ପେଟ ଯନ୍ତ୍ରଣା, ଛୋଟ ଆଖି ପୁଅ, ଝାଳ ଏବଂ ଅଣନିଶ୍ୱାସ ହୋଇପାରେ ।^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାତ, ବ୍ରଙ୍କୋସ୍ପାଜ୍ମ, କୋଲିନରଜିକ୍ ସଙ୍କଟ ଏବଂ ଆସିସ୍ଟୋଲ ହୋଇପାରେ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ ।^[୨] ଏହା ଏକ କୋଲିନଇଷ୍ଟରେଜ୍ ନିରୋଧକ ।^[୧]

ଫାଇସୋଷ୍ଟିଗମିନ ମୂଳତଃ କାଲାବର ବିନ୍‌ରୁ ପ୍ରସ୍ତୁତ ହୋଇଥିଲା ।^[୩] ଚିକିତ୍ସାରେ ଏହାର ବ୍ୟବହାର ୧୮୬୨ ମସିହାରେ ଏଡିନବର୍ଗ ୟୁନିଭରସିଟିରେ ଥୋମାସ୍ ରିଚାର୍ଡ ଫ୍ରେଜରଙ୍କ ଥେସିସରେ ଆଲୋଚନା କରାଯାଇଥିଲା।^[୩] ୧୯୩୫ ମସିହାରେ ଏହାର ଉତ୍ପାଦନ ପ୍ରଥମେ ପର୍ସି ଲାଭୋନ ଜୁଲିଆନ କରିଥିଲେ ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨ ମିଗ୍ରାର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୮୦ ଡଲାର ଥିଲା ।^[୫]

ଆଧାର

1 2 3 4 5 "Physostigmine Monograph for Professionals". Drugs.com. Archived from the original on 28 January 2021. Retrieved 28 October 2021.
↑ "Physostigmine (Antilirium) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2020. Retrieved 28 October 2021.
1 2 Doyle D (January 2009). "Sir Thomas Richard Fraser (1841–1920)" (PDF). JR Coll Physicians Edinb. 39: 283. Archived from the original (PDF) on 2021-01-25. Retrieved 2021-10-08.
↑ Sundberg, Richard J. (31 March 2017). The Chemical Century: Molecular Manipulation and Its Impact on the 20th Century (in ଇଂରାଜୀ). CRC Press. p. 331. ISBN 978-1-77188-367-2. Archived from the original on 28 October 2021. Retrieved 28 October 2021.
↑ "Physostigmine Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 28 October 2021.

[AHFS2021-1] 1 2 3 4 5 "Physostigmine Monograph for Professionals". Drugs.com. Archived from the original on 28 January 2021. Retrieved 28 October 2021.

[2] "Physostigmine (Antilirium) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2020. Retrieved 28 October 2021.

[His2009-3] 1 2 Doyle D (January 2009). "Sir Thomas Richard Fraser (1841–1920)" (PDF). JR Coll Physicians Edinb. 39: 283. Archived from the original (PDF) on 2021-01-25. Retrieved 2021-10-08.

[4] Sundberg, Richard J. (31 March 2017). The Chemical Century: Molecular Manipulation and Its Impact on the 20th Century (in ଇଂରାଜୀ). CRC Press. p. 331. ISBN 978-1-77188-367-2. Archived from the original on 28 October 2021. Retrieved 28 October 2021.

[5] "Physostigmine Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 28 October 2021.

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