ସିଷ୍ଟିମାଇନ

ସିଷ୍ଟିମାଇନ
INN: mercaptamine
	Skeletal formula (top); Ball-and-stick model of the cysteamine
Clinical data
Trade names	Cystagon, Procysbi, Cystaran, others
Synonyms	Mercaptamine bitartrate, 2-Aminoethanethiol, β-Mercaptoethylamine, 2-Mercaptoethylamine, decarboxycysteine, thioethanolamine, cysteamine (USAN US)
AHFS/Drugs.com	monograph
data	EU EMA: yes; US DailyMed: Cysteamine;
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth, eye drops
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Identifiers
	IUPAC name 2-Aminoethane-1-thiol;
ECHA InfoCard	100.000.421
Chemical and physical data
Formula	C2H7NS
Molar mass	୭୭.୧୫ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	95 to 97 °C (203 to 207 °F)
	SMILES C(CS)N;
	InChI InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2 ; Key:UFULAYFCSOUIOV-UHFFFAOYSA-N;

ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Cysteamine

ସିଷ୍ଟିମାଇନ, ମର୍କାପ୍ଟାମାଇନ୍ ଭାବରେ ମଧ୍ୟ ଜଣାଶୁଣା, ଏକ ଔଷଧ ଯାହା ସିଷ୍ଟିନୋସିସ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୭] ବୃକ୍‌କର ଚିକିତ୍ସା କରିବା ପାଇଁ ପାଟିରେ ଔଷଧ ଦିଆଯାଏ ଏବଂ ଆଖି ପାଇଁ ଆଖି ବୁନ୍ଦା ପକାଯାଏ ।^[୧] ^[୬] ଶ୍ୱେତ ରକ୍ତ କଣିକାରେ ସିଷ୍ଟିନ ସ୍ତର ଉପରେ ଆଧାର କରି ଏହାର ମାତ୍ରା ସଜାଡ଼ିବା ଉଚିତ୍ ।^[୧]

ପାଟିରେ ଔଷଧ ଦେଲେ ସାଧାରଣତଃ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ତରଳ ଝାଡ଼ା ଏବଂ ଜ୍ୱର ହୋଇପାରେ ।^[୧] ଆଖିରେ ବୁନ୍ଦା ପକେଇଲେ ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଖିର ଉତ୍ତେଜନା, ଜଳୀୟ ଆଖି ଏବଂ ଅସ୍ପଷ୍ଟ ଦୃଷ୍ଟିଶକ୍ତି ହୋଇପାରେ ।^[୨] ଗର୍ଭାବସ୍ଥାରେ ନିରାପତ୍ତା ଅସ୍ପଷ୍ଟ, ଅନ୍ୟ ପ୍ରାଣୀମାନଙ୍କରେ କ୍ଷତି ହେବାର ପ୍ରମାଣ ଅଛି | ^[୮] ଏହା ସିଷ୍ଟିନ (cystine) ସ‌ହିତ ସିଷ୍ଟିମାଇନ ପ୍ରତିକ୍ରିୟା କରି ସିଷ୍ଟାଇନ୍ (cysteine) ଏବଂ ଶରୀର ଲୁଣ ପ୍ରସ୍ତୁତ କରେ ଯାହା ଦେହ ବାହାର କରିଦେଇପାରେ ।^[୧]

୧୯୯୪ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୧୯୯୭ରେ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ସିଷ୍ଟିମାଇନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୭] ^[୧] ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ୧୦୦ ମିଗ୍ରା ବିଶିଷ୍ଟ ୧୦୦ଟି ବଟିକାର ମୂଲ୍ୟ ପ୍ରାୟ ୧୯୦ ପାଉଣ୍ଡ; ୨୦୨୧ ମସିହା ସୁଦ୍ଧା ୫ ମିଲି ଆଖି ବୁନ୍ଦା ମୂଲ୍ୟ ପ୍ରାୟ ୮୬୫ ପାଉଣ୍ଡ ଅଟେ ।^[୯] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣ ବଟିକାର ମୂଲ୍ୟ ପ୍ରାୟ ୨୨,୨୦୦ ଡଲାର ଅଟେ ଓ ଆଖି ବୁନ୍ଦା ମୂଲ୍ୟ ପ୍ରାୟ ୨,୦୦୦ ଡଲାର୍ | ^[୧୦] ^[୧୧]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Cystagon EPAR".
↑ ^୨.୦ ^୨.୧ "Cystadrops EPAR".
↑ "Cystagon 150 mg hard capsules - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Archived from the original on 9 June 2021. Retrieved 28 April 2020.
↑ "Cystadrops 3.8 mg/mL eye drops solution - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Archived from the original on 9 June 2020. Retrieved 9 June 2020.
↑ "Procysbi 25 mg gastro-resistant hard capsules - Summary of Product Characteristics (SmPC)". (emc). 17 September 2019. Archived from the original on 22 January 2021. Retrieved 9 June 2020.
↑ ^୬.୦ ^୬.୧ "Cystaran- cysteamine hydrochloride solution".
↑ ^୭.୦ ^୭.୧ "Cysteamine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 January 2022. Retrieved 7 January 2022.
↑ "Cysteamine ophthalmic Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 7 January 2022.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1111. ISBN 978-0857114105.
↑ "Procysbi Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 16 January 2021. Retrieved 7 January 2022.
↑ "Cystadrops Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 7 January 2022.

[EPAR2022Mouth-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Cystagon EPAR".

[EPAR2022Eye-2] ୨.୦ ^୨.୧ "Cystadrops EPAR".

[3] "Cystagon 150 mg hard capsules - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Archived from the original on 9 June 2021. Retrieved 28 April 2020.

[4] "Cystadrops 3.8 mg/mL eye drops solution - Summary of Product Characteristics (SmPC)". (emc). 19 June 2019. Archived from the original on 9 June 2020. Retrieved 9 June 2020.

[5] "Procysbi 25 mg gastro-resistant hard capsules - Summary of Product Characteristics (SmPC)". (emc). 17 September 2019. Archived from the original on 22 January 2021. Retrieved 9 June 2020.

[USlabelEye-6] ୬.୦ ^୬.୧ "Cystaran- cysteamine hydrochloride solution".

[Liv2022-7] ୭.୦ ^୭.୧ "Cysteamine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 January 2022. Retrieved 7 January 2022.

[8] "Cysteamine ophthalmic Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 7 January 2022.

[BNF81-9] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1111. ISBN 978-0857114105.

[10] "Procysbi Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 16 January 2021. Retrieved 7 January 2022.

[11] "Cystadrops Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 7 January 2022.

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