ବାକ୍ଲୋଫେନ

ବାକ୍ଲୋଫେନ
Clinical data
Trade names	Lioresal, Liofen, Gablofen, others
Synonyms	β-(4-chlorophenyl)-γ-aminobutyric acid (β-(4-chlorophenyl)-GABA)
AHFS/Drugs.com	monograph
MedlinePlus	a682530
data	US DailyMed: Baclofen;
Pregnancy; category	AU: B3 ;
Routes of; administration	By mouth, intrathecal
ATC code	M03BX01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	Well-absorbed
Protein binding	30%
Metabolism	85% excreted in urine/faeces unchanged. 15% metabolised by deamination
Elimination half-life	1.5 to 4 hours
Excretion	Kidney (70–80%)
Identifiers
	IUPAC name (RS)-4-Amino-3-(4-chlorophenyl)butanoic acid;
CAS Number	1134-47-0 ;
PubChem CID	2284;
IUPHAR/BPS	1084;
DrugBank	DB00181 ;
ChemSpider	2197 ;
UNII	H789N3FKE8;
KEGG	D00241 ;
ChEBI	CHEBI:2972 ;
ChEMBL	CHEMBL701 ;
ECHA InfoCard	100.013.170
Chemical and physical data
Formula	C10H12ClNO2
Molar mass	୨୧୩.୬୬ g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES NCC(CC(=O)O)c1ccc(Cl)cc1;
	InChI InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14) ; Key:KPYSYYIEGFHWSV-UHFFFAOYSA-N ;
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ବାକ୍ଲୋଫେନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବିକ୍ରୟ ନାମ ଲିଓରେସାଲ, ଏକ ଔଷଧ ଯାହା ଏକାଧିକ ସ୍କ୍ଲେରୋସିସ ଓ ମେରୁଦଣ୍ଡରେ ଜାତ ହେଉଥିବା ମାଂସପେଶୀର ସ୍ପାଷ୍ଟିସିଟିର ଚିକିତ୍ସା କରିବା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୬] ^[୭] ଏହା ଜୀବନର ଆନ୍ତିମ ଭାଗରେ ହେଉଥିବା ହିକ୍କା ଓ ମାଂସପେଶୀର ସ୍ପାଜ୍ମ ନିମନ୍ତେ ବ୍ୟବହୃତ ହୋଇପାରେ | ^[୮] ଏହା ପାଟିରେ କିମ୍ବା ସ୍ପାଇନାଲ କେନାଲ ଭିତରେ ଦିଆଯାଏ ।^[୯]

ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ ଭାବ, ଦୁର୍ବଳତା ଓ ମୁଣ୍ଡ ବୁଲା ହୋଇପାରେ ।.^[୬] ହଠାତ ଔଷଧ ସେବନ ବନ୍ଦ କରିଦେଲେ ଗମ୍ଭୀର ପ୍ରତିକ୍ରିୟାରେ ବାତ ଓ ରାବଡୋମାୟୋଲାଇସିସ ହୋଇପାରେ । ଗର୍ଭାବସ୍ଥାରେ ଏହାର ବିପଦ ଅସ୍ପଷ୍ଟ ରହିଛି କିନ୍ତୁ ସ୍ତନ୍ୟପାନ ନିମନ୍ତେ ବୋଧହୁଏ ବିପଦମୁକ୍ତ ଅଛି ।^[୧୦] ନିଉରୋଟ୍ରାନ୍ସମିଟ କମେଇ ଦେଇ କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।

୧୯୭୭ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ବ୍ୟାକ୍ଲୋଫେନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୬] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ^[୭] ଦିନକୁ ୫୦ ମିଗ୍ରା ମାତ୍ରାରେ ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାସ ଯୋଗାଣ ପାଇଁ ୨୦୧୦ ସୁଦ୍ଧା ୫.୫୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରିଥାଏ।^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୮.୪୦ ଆମେରିକୀୟ ଡଲାର ଅଟେ।^[୧୧] ୨୦୧୭ ରେ, ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୪୦ ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଚାରି ନିୟୁତରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା | ^[୧୨] ^[୧୩]

ଆଧାର

↑ ଆଧାର ଭୁଲ: ଅଚଳ <ref> ଚିହ୍ନ; Gablofen FDA label ନାମରେ ଥିବା ଆଧାର ଭିତରେ କିଛି ଲେଖା ନାହିଁ ।
↑ "Lioresal- baclofen injection". DailyMed. Retrieved 7 November 2021.
↑ "Ozobax- baclofen solution". DailyMed. Retrieved 7 November 2021.
↑ "Lyvispah- baclofen granule". DailyMed. Retrieved 19 December 2021.
↑ "Fleqsuvy- baclofen suspension". DailyMed. 4 February 2022. Retrieved 16 March 2022.
1 2 3 "Baclofen Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 26 April 2019. Retrieved 3 March 2019.
1 2 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1190-1191. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
1 2 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1190-1191. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Baclofen Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 26 April 2019. Retrieved 3 March 2019.
↑ "Baclofen Pregnancy and Breastfeeding Warnings". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2018. Retrieved 3 March 2019.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
↑ "Baclofen - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.

[Gablofen_FDA_label-1] ଆଧାର ଭୁଲ: ଅଚଳ <ref> ଚିହ୍ନ; Gablofen FDA label ନାମରେ ଥିବା ଆଧାର ଭିତରେ କିଛି ଲେଖା ନାହିଁ ।

[Lioresal_FDA_label-2] "Lioresal- baclofen injection". DailyMed. Retrieved 7 November 2021.

[Ozobax_FDA_label-3] "Ozobax- baclofen solution". DailyMed. Retrieved 7 November 2021.

[Lyvispah_FDA_label-4] "Lyvispah- baclofen granule". DailyMed. Retrieved 19 December 2021.

[5] "Fleqsuvy- baclofen suspension". DailyMed. 4 February 2022. Retrieved 16 March 2022.

[AHFS2019-6] 1 2 3 "Baclofen Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 26 April 2019. Retrieved 3 March 2019.

[BNF80-7] 1 2 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1190-1191. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[autogen2-8] 1 2 BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1190-1191. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[autogen3-9] "Baclofen Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 26 April 2019. Retrieved 3 March 2019.

[Preg2019-10] "Baclofen Pregnancy and Breastfeeding Warnings". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2018. Retrieved 3 March 2019.

[NADAC2019-11] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[ref-12] "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.

[ref1-13] "Baclofen - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.

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