ସେନୋବାମେଟ

ସେନୋବାମେଟ
Clinical data
Trade names	Xcopri, Ontozry
Synonyms	YKP3089
AHFS/Drugs.com	monograph
MedlinePlus	a620021
data	EU EMA: yes; US DailyMed: Cenobamate;
Routes of; administration	By mouth
Legal status
Legal status	US: Schedule V ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	≥88%
Protein binding	60%
Metabolism	Mainly glucuronidation via UGT2B7
Elimination half-life	50–60 hours
Excretion	Mainly via urine
Identifiers
	IUPAC name [(1R)-1-(2-chlorophenyl)-2-(tetrazol-2-yl)ethyl] carbamate;
Chemical and physical data
Formula	C10H10ClN5O2
Molar mass	୨୬୭.୬୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C(=C1)C(CN2N=CN=N2)OC(=O)N)Cl;
	InChI InChI=1S/C10H10ClN5O2/c11-8-4-2-1-3-7(8)9(18-10(12)17)5-16-14-6-13-15-16/h1-4,6,9H,5H2,(H2,12,17)/t9-/m0/s1; Key:GFHAXPJGXSQLPT-VIFPVBQESA-N;

ସେନୋବାମେଟ, ବେପାର ନାମ ଏକ୍ସକୋପ୍ରି (Xcopri) ଏବଂ ଓଣ୍ଟୋଜ୍ରି (Ontozry) ଏକ ଔଷଧ ଯାହା ଅପସ୍ମାରର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ, ବିଶେଷ ଭାବରେ ଫୋକାଲ୍-ଅନସେଟ୍ ଅପସ୍ମାର ନିମନ୍ତେ । ^[୨] ଏହା ଅନ୍ୟାନ୍ୟ ଔଷଧ ସହିତ ଏକତ୍ର ବ୍ୟବହୃତ କରାଯାଇପାରେ । ^[୧] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ ଭାବ, ମୁଣ୍ଡ ବୁଲାଇବା, ଥକାପଣ, ଦ୍ୱିତ ଦୃଷ୍ଟି, ଏବଂ ମୁଣ୍ଡବିନ୍ଧା ହୋଇପାରେ । ^[୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କ୍ଷୁଦ୍ର କ୍ୟୁଟି (QT), ଇଓସିନୋଫିଲିଆ ସ‌ହିତ ଔଷଧ ପ୍ରତିକ୍ରିୟା (DRESS) ଏବଂ ଆତ୍ମହତ୍ୟା ପ୍ରବଣ ହୋଇପାରେ । ^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ । ^[୨] ଏହା କିପରି କାର୍ଯ୍ୟ କରେ ତାହା ସମ୍ପୂର୍ଣ୍ଣ ସ୍ପଷ୍ଟ ନୁହେଁ; ତଥାପି, ଏହା ଆୟନ ଚ୍ୟାନେଲଗୁଡ଼ିକୁ ପରିବର୍ତ୍ତନ କରେ । ^[୨]

୨୦୧୯ ମସିହାରେ ଆମେରିକାରେ ଏବଂ ୨୦୨୧ରେ ୟୁରୋପରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ସେନୋବାମେଟ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ^[୧] ଏହା ନିୟନ୍ତ୍ରିତ ପଦାର୍ଥ ଅଧିନିୟମର ସିଡ୍ୟୁଲ୍ ୫ରେ (V) ଅଛି। ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୦୦ ମିଗ୍ରାର ୩୦ଟି ବଟିକାର ମୂଲ୍ୟ ୨୦୨୨ ସୁଦ୍ଧା ପ୍ରାୟ ୧୦୦୦ ଡଲାର ଅଟେ । ^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Ontozry EPAR". European Medicines Agency (EMA). 25 January 2021. Archived from the original on 4 June 2021. Retrieved 4 June 2021. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Xcopri Titration Pack- cenobamate kit Xcopri- cenobamate tablet, film coated Xcopri Maintenance Pack- cenobamate kit". DailyMed. Archived from the original on 11 August 2020. Retrieved 1 February 2021.
↑ "Schedules of Controlled Substances: Placement of Cenobamate in Schedule V". Federal Register. 10 March 2020. Archived from the original on 3 April 2021. Retrieved 4 August 2021.
↑ "Cenobamate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 January 2022.
↑ "2020 - Placement of Cenobamate in Schedule V". DEA Diversion Control Division. 10 March 2020. Archived from the original on 19 April 2020. Retrieved 11 March 2020.
↑ "Xcopri Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 19 October 2021. Retrieved 3 January 2022.

[EPAR2021-1] ୧.୦ ^୧.୧ ^୧.୨ "Ontozry EPAR". European Medicines Agency (EMA). 25 January 2021. Archived from the original on 4 June 2021. Retrieved 4 June 2021. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[PI2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Xcopri Titration Pack- cenobamate kit Xcopri- cenobamate tablet, film coated Xcopri Maintenance Pack- cenobamate kit". DailyMed. Archived from the original on 11 August 2020. Retrieved 1 February 2021.

[3] "Schedules of Controlled Substances: Placement of Cenobamate in Schedule V". Federal Register. 10 March 2020. Archived from the original on 3 April 2021. Retrieved 4 August 2021.

[AHFS2022-4] "Cenobamate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 January 2022.

[5] "2020 - Placement of Cenobamate in Schedule V". DEA Diversion Control Division. 10 March 2020. Archived from the original on 19 April 2020. Retrieved 11 March 2020.

[6] "Xcopri Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 19 October 2021. Retrieved 3 January 2022.

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