ଲେଭୋରଫାନୋଲ

ଲେଭୋରଫାନୋଲ
Clinical data
Trade names	Levo-Dromoran
Synonyms	Ro 1-5431
AHFS/Drugs.com	monograph
MedlinePlus	a682020
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S8 (Controlled) ; CA: Schedule I ; DE: Anlage II (Prohibited) ; UK: Class A ; US: Schedule II ;
Pharmacokinetic data
Bioavailability	70% (by mouth); 100% (IV)
Protein binding	40%
Metabolism	Liver
Onset of action	With 1 hr
Elimination half-life	11–16 hours
Duration of action	Up to 8 hrs
Identifiers
	IUPAC name (1R,9R,10R)-17-Methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol;
ECHA InfoCard	100.000.912
Chemical and physical data
Formula	C17H23NO
Molar mass	୨୫୭.୩୮ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc4c3cc(O)cc4;
	InChI InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1 ; Key:JAQUASYNZVUNQP-USXIJHARSA-N ;
(verify)

ଲେଭୋରଫାନୋଲ, ଏକ ବିକ୍ରୟ ନାମ ଲେଭୋ-ଡ୍ରୋମୋରାନ, ହେଉଛି, ଏକ ଓପିଅଏଡ଼ ବା ଅଫିମ ସମ୍ପର୍କୀୟ ଔଷଧ ଯାହା ମଧ୍ୟମରୁ ପ୍ରବଳ ଯନ୍ତ୍ରଣାର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩] ଏହାର ସର୍ବାଧିକ ପ୍ରଭାବ ଏକ ଘଣ୍ଟା ମଧ୍ୟରେ ଆରମ୍ଭ ହୋଇ ପ୍ରାୟ ୮ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ ।^[୨] ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ଲାଲିମା, ମୂତ୍ରରୋଧ, ଗଲୁ ଏବଂ କୋଷ୍ଠକାଠିନ୍ୟ ହୋଇପାରେ ।^[୩] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସ୍ୱଳ୍ପ ଶ୍ୱାସକ୍ରିୟା ବା ଶ୍ୱାସକ୍ରିୟା ଅବସାଦ, ଅପବ୍ୟବହାର, ସେରୋଟୋନିନ ସିଣ୍ଡ୍ରୋମ ଏବଂ ନିମ୍ନ ରକ୍ତଚାପ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ ।^[୪]

ଲେଭୋରଫାନୋଲ ପ୍ରଥମେ ଜର୍ମାନୀରେ ୧୯୪୬ ମସିହାରେ ବର୍ଣ୍ଣନା କରାଯାଇଥିଲା ।^[୫] ୧୯୫୩ ମସିହା ପରଠାରୁ ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାରରେ ହେଉଛି ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦ ମିଗ୍ରାର ୯୦ ବଟିକା ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୧୧୦୦ ଡଲାର ଥିଲା ।^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ଏକ ଅନୁସୂଚୀତ ୨ ନିୟନ୍ତ୍ରିତ ପଦାର୍ଥ ଅଟେ ।^[୩]

ଆଧାର[ସମ୍ପାଦନା]

↑ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 656–. ISBN 978-1-4757-2085-3.
↑ ^୨.୦ ^୨.୧ Hogans, Beth B.; Barreveld, Antje M. (7 November 2019). Pain Care Essentials (in ଇଂରାଜୀ). Oxford University Press. p. PT164. ISBN 978-0-19-009142-2. Archived from the original on 11 December 2021. Retrieved 22 November 2021.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ "Levorphanol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 January 2021. Retrieved 22 November 2021.
↑ "Levorphanol (Levo-Dromoran) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 November 2020. Retrieved 22 November 2021.
↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 527. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2021-10-21.
↑ Gudin J, Fudin J, Nalamachu S (January 2016). "Levorphanol Use: Past, Present and Future". Postgraduate Medicine. 128 (1): 46–53. doi:10.1080/00325481.2016.1128308. PMID 26635068.
↑ "Levorphanol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 22 November 2021.

[Elks2014-1] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 656–. ISBN 978-1-4757-2085-3.

[Hog2019-2] ୨.୦ ^୨.୧ Hogans, Beth B.; Barreveld, Antje M. (7 November 2019). Pain Care Essentials (in ଇଂରାଜୀ). Oxford University Press. p. PT164. ISBN 978-0-19-009142-2. Archived from the original on 11 December 2021. Retrieved 22 November 2021.

[AHFS2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ "Levorphanol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 January 2021. Retrieved 22 November 2021.

[4] "Levorphanol (Levo-Dromoran) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 November 2020. Retrieved 22 November 2021.

[Fis2006-5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 527. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2021-10-21.

[Gud2016-6] Gudin J, Fudin J, Nalamachu S (January 2016). "Levorphanol Use: Past, Present and Future". Postgraduate Medicine. 128 (1): 46–53. doi:10.1080/00325481.2016.1128308. PMID 26635068.

[7] "Levorphanol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 22 November 2021.

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