ମିଫେପ୍ରିସ୍ଟୋନ

ମିଫେପ୍ରିସ୍ଟୋନ
Clinical data
Trade names	Mifeprex
AHFS/Drugs.com	monograph
MedlinePlus	a600042
Pregnancy; category	US: X (Contraindicated) ; Used for terminating pregnancy;
Routes of; administration	By mouth
ATC code	G03XB01 (WHO) ;
Legal status
Legal status	US: ℞-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	69%
Protein binding	98%
Metabolism	Liver
Elimination half-life	18 hours
Excretion	Fecal: 83%; Kidney: 9%
Identifiers
	IUPAC name 11β-[p-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one;
CAS Number	84371-65-3 ;
PubChem CID	55245;
IUPHAR/BPS	2805;
DrugBank	DB00834 ;
ChemSpider	49889 ;
UNII	320T6RNW1F;
KEGG	D00585 ;
ChEBI	CHEBI:50692 ;
ChEMBL	CHEMBL157 ;
ECHA InfoCard	100.127.911
Chemical and physical data
Formula	C29H35NO2
Molar mass	429.60 g/mol
3D model (JSmol)	Interactive image;
Density	1.189 g/cm3
Melting point	194 °C (381 °F)
Boiling point	629 °C (1,164 °F)
	SMILES O=C5\C=C4/C(=C3/[C@@H](c1ccc(N(C)C)cc1)C[C@]2([C@@H](CC[C@]2(C#CC)O)[C@@H]3CC4)C)CC5;
	InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1 ; Key:VKHAHZOOUSRJNA-GCNJZUOMSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Mifepristone

ମିଫେପ୍ରିସ୍ଟୋନ, ଅନ୍ୟ ନାମ ଆର‌ୟୁ-୪୮୬ (RU-486), ଏକ ଔଷଧ ଯାହା ଗର୍ଭପାତ କରିବା ନିମନ୍ତେ ମିସୋପ୍ରିସ୍ଟଲ ସ‌ହିତ ମିଶେଇ ଦିଆଯାଏ ।^[୧] ଏହି ସଂଯୁକ୍ତ ଔଷଧ ଗର୍ଭାବସ୍ଥାର ପ୍ରଥମ ୫୦ ଦିନ ମଧ୍ୟରେ ୯୫ % ଫଳପ୍ରଦ ରହେ । ଦ୍ୱିତୀୟ ତ୍ରୈମାସିକରେ ମଧ୍ୟ ଏହା ଫଳପ୍ରଦ ହୁଏ ।^[୨]^[୩] ବ୍ୟବ‌ହାରର ୨ ସପ୍ତାହ ପରେ ଏହାର ପ୍ରଭାବ ପରୀକ୍ଷା କରି ଦେଖିବା ଆବଶ୍ୟକ । ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୧]

ଏହାର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ମଧ୍ୟରେ ପେଟ ଯନ୍ତ୍ରଣା, ଥକ୍କା ଲାଗିବା ଓ ଯୋନୀରୁ ରକ୍ତସ୍ରାବ ହୁଏ । ସାଂଘାତିକ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ମଧ୍ୟରେ ଅତ୍ୟଧିକ ଯୋନୀ ରକ୍ତସ୍ରାବ, ଜୀବାଣୁ ସଂକ୍ରମଣ ଓ ଗର୍ଭପାତ ନ ହେଲେ ବିକଳାଙ୍ଗ ଶିଶୁ ସୃଷ୍ଟି ହୁଏ । ଉପ‌ଯୁକ୍ତ ଅନୁସରଣ ଯତ୍ନ ସୁବିଧା ଥିଲେ ଏହା ବ୍ୟବ‌ହାର କରିବା ଉଚିତ । ପ୍ରୋଜେସ୍ଟେରନର ପ୍ରଭାବ ବାଧା ଦେଇ ଏହା ଜରାୟୁ ସଙ୍କୋଚନ କରେ ।^[୧]

ସନ ୧୯୮୦ରେ ଏହା ପ୍ରସ୍ତୁତ ହୋଇ ଫ୍ରାନ୍ସରେ ସନ ୧୯୮୭ରେ ବ୍ୟବ‌ହାର କରାଗଲା ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହା ସନ ୨୦୦୦ରେ ଉପଲବ୍‌ଧ ହେଲା । ^[୨] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୫] ସନ ୨୦୧୪ ସୁଦ୍ଧା ଏହା କାନାଡ଼ା ଓ ଅଷ୍ଟ୍ରେଲିଆରେ ମିଳିପାରି ନାହିଁ । ^[୬] ବିକାଶଶୀଳ ପୃଥିବୀରେ ଏହାର ଅଧିକ ମୂଲ୍ୟ ଯୋଗୁ ମିଳୁନାହିଁ ।^[୭]^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହା ଡୋଜ ପ୍ରତି ସନ ୨୦୧୫ରେ ୨୦୦ଡଲାରରୁ ଅଧିକ ମୂଲ୍ୟ ହେଉଛି । ^[୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Mifepristone". The American Society of Health-System Pharmacists. Retrieved December 19, 2015.
↑ ^୨.୦ ^୨.୧ Rexrode, edited by Marlene Goldman, Rebecca Troisi, Kathryn (2012). Women and health (2nd ed.). Oxford: Academic. p. 236. ISBN 9780123849793. {{cite book}}: |first1= has generic name (help)CS1 maint: multiple names: authors list (link)
↑ Wildschut, H; Both, MI; Medema, S; Thomee, E; Wildhagen, MF; Kapp, N (19 January 2011). "Medical methods for mid-trimester termination of pregnancy". The Cochrane database of systematic reviews (1): CD005216. doi:10.1002/14651858.CD005216.pub2. PMID 21249669.
↑ Corey, E.J. (2012). "Mifepristone". Molecules and Medicine. John Wiley & Sons. ISBN 9781118361733.
↑ "19th WHO Model List of Essential Medicines (April 2015)" (PDF). WHO. April 2015. Retrieved May 10, 2015.
↑ Nelson, Erin (2014). "Access to Abortion Services". Law, Policy and Reproductive Autonomy. A&C Black. ISBN 9781782251569.
↑ Hussein, edited by Julia; McCaw-Binns,, Affette; Webber, Roger (2012). Maternal and perinatal health in developing countries. Wallingford, Oxfordshire: CABI. p. 104. ISBN 9781845937461. {{cite book}}: |first1= has generic name (help)CS1 maint: extra punctuation (link)
↑ Winikoff, B; Sheldon, W (September 2012). "Use of medicines changing the face of abortion". International perspectives on sexual and reproductive health. 38 (3): 164–6. doi:10.1363/3816412. PMID 23018138.
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 368. ISBN 9781284057560.

[AHFS2015-1] ୧.୦ ^୧.୧ ^୧.୨ "Mifepristone". The American Society of Health-System Pharmacists. Retrieved December 19, 2015.

[Rex2012-2] ୨.୦ ^୨.୧ Rexrode, edited by Marlene Goldman, Rebecca Troisi, Kathryn (2012). Women and health (2nd ed.). Oxford: Academic. p. 236. ISBN 9780123849793. {{cite book}}: |first1= has generic name (help)CS1 maint: multiple names: authors list (link)

[3] Wildschut, H; Both, MI; Medema, S; Thomee, E; Wildhagen, MF; Kapp, N (19 January 2011). "Medical methods for mid-trimester termination of pregnancy". The Cochrane database of systematic reviews (1): CD005216. doi:10.1002/14651858.CD005216.pub2. PMID 21249669.

[4] Corey, E.J. (2012). "Mifepristone". Molecules and Medicine. John Wiley & Sons. ISBN 9781118361733.

[WHO2015E-5] "19th WHO Model List of Essential Medicines (April 2015)" (PDF). WHO. April 2015. Retrieved May 10, 2015.

[6] Nelson, Erin (2014). "Access to Abortion Services". Law, Policy and Reproductive Autonomy. A&C Black. ISBN 9781782251569.

[7] Hussein, edited by Julia; McCaw-Binns,, Affette; Webber, Roger (2012). Maternal and perinatal health in developing countries. Wallingford, Oxfordshire: CABI. p. 104. ISBN 9781845937461. {{cite book}}: |first1= has generic name (help)CS1 maint: extra punctuation (link)

[8] Winikoff, B; Sheldon, W (September 2012). "Use of medicines changing the face of abortion". International perspectives on sexual and reproductive health. 38 (3): 164–6. doi:10.1363/3816412. PMID 23018138.

[Ric2015-9] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 368. ISBN 9781284057560.

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