ବେଲିନୋଷ୍ଟାଟ

ବେଲିନୋଷ୍ଟାଟ
Clinical data
Trade names	Beleodaq
Synonyms	PXD101
AHFS/Drugs.com	monograph
Pregnancy; category	US: D (Evidence of risk) ; ;
Routes of; administration	Intravenous (IV)
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	100% (IV)
Protein binding	92.9–95.8%
Metabolism	UGT1A1
Excretion	Urine
Identifiers
	IUPAC name (2E)-N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide;
Chemical and physical data
Formula	C15H14N2O4S
Molar mass	୩୧୮.୩୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(Nc1ccccc1)c2cc(\C=C\C(=O)NO)ccc2;
	InChI InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+ ; Key:NCNRHFGMJRPRSK-MDZDMXLPSA-N ;

ବେଲିନୋଷ୍ଟାଟ, ବେପାର ନାମ ବେଲୋଡାକ, ଏକ ଔଷଧ ଯାହା ପେରିଫେରାଲ ଟି-ସେଲ ଲିମ୍ଫୋମା ରୋଗର (PTCL)ର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୨] ଯେତେବେଳେ ଅନ୍ୟ ଚିକିତ୍ସା ବିଫଳ ହୁଏ ସେତେବେଳେ ଏହା ବ୍ୟବହୃତ ହୁଏ । ^[୩] ୨୦୨୦ ସୁଦ୍ଧା ଏହା ଆୟୁଷକୁ ଉନ୍ନତ କରେ କି ନାହିଁ ତାହା ବିଷୟରେ ଅସ୍ପଷ୍ଟ ଅଛି ।^[୪] ଏହା ଶିରାରେ ଇଞ୍ଜେକ୍ସନ ଆକାରରେ ଦିଆଯାଏ । ^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ଥକାପଣ, ଜ୍ୱର ଏବଂ ସ୍ୱଳ୍ପ ଲୋହିତ ରକ୍ତ କଣିକା ଅନ୍ତର୍ଭୁକ୍ତ । ^[୩] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଥ୍ରୋମ୍ବୋସାଇଟପେନିଆ, ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତ କଣିକା, ସଂକ୍ରମଣ, ଯକୃତ ସମସ୍ୟା ଏବଂ ଟ୍ୟୁମର ଲାଇସିସ୍ ସିଣ୍ଡ୍ରୋମ ଅନ୍ତର୍ଭୁକ୍ତ । ^[୪] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ | ^[୪] ଏହା ଏକ ହିଷ୍ଟୋନ୍ ଡିସିଟିଇଲେଜ ନିରୋଧକ । ^[୨]

୨୦୧୪ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ବେଲିନୋଷ୍ଟାଟକୁ ଅନୁମୋଦନ କରାଯାଇଥିଲା। ^[୩] ଏହାକୁ ୨୦୧୨ରେ ୟୁରୋପରେ ଏକ ଅନାଥ ନାମ ଦିଆଯାଇଥିଲା। ^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୨ ସୁଦ୍ଧା ଏକ ୫୦୦ ମିଗ୍ରା ଭାଏଲର ମୂଲ୍ୟ ପ୍ରାୟ ୨୧୦୦ ଡଲାର ଅଟେ । ^[୭]

ଆଧାର[ସମ୍ପାଦନା]

↑ "Beleodaq (belinostat) For Injection, For Intravenous Administration. Full Prescribing Information" (PDF). Spectrum Pharmaceuticals, Inc. Irvine, CA 92618. Archived from the original (PDF) on 4 March 2016. Retrieved 21 November 2015.
↑ ^୨.୦ ^୨.୧ "Belinostat Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 8 January 2022.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "DailyMed - BELEODAQ- belinostat injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 25 March 2021. Retrieved 8 January 2022.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "DailyMed - BELEODAQ- belinostat injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 25 March 2021. Retrieved 8 January 2022.
↑ "Belinostat Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 8 January 2022.
↑ "EU/3/12/1055: Orphan designation for the treatment of peripheral T-cell lymphoma (nodal, other extranodal and leukaemic/disseminated)". Archived from the original on 11 January 2022. Retrieved 8 January 2022.
↑ "Belinostat Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 8 January 2022.

[1] "Beleodaq (belinostat) For Injection, For Intravenous Administration. Full Prescribing Information" (PDF). Spectrum Pharmaceuticals, Inc. Irvine, CA 92618. Archived from the original (PDF) on 4 March 2016. Retrieved 21 November 2015.

[AHFS2022-2] ୨.୦ ^୨.୧ "Belinostat Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 8 January 2022.

[PI2022-3] ୩.୦ ^୩.୧ ^୩.୨ "DailyMed - BELEODAQ- belinostat injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 25 March 2021. Retrieved 8 January 2022.

[autogen1-4] ୪.୦ ^୪.୧ ^୪.୨ "DailyMed - BELEODAQ- belinostat injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 25 March 2021. Retrieved 8 January 2022.

[autogen3-5] "Belinostat Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 8 January 2022.

[6] "EU/3/12/1055: Orphan designation for the treatment of peripheral T-cell lymphoma (nodal, other extranodal and leukaemic/disseminated)". Archived from the original on 11 January 2022. Retrieved 8 January 2022.

[7] "Belinostat Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 8 January 2022.

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