ଫ୍ଲୁନିଟ୍ରାଜେପାମ

ଫ୍ଲୁନିଟ୍ରାଜେପାମ
Clinical data
Pronunciation	/ˌfluːnɪˈtræzɪpæm/
Trade names	Rohypnol, others
Synonyms	Circles, Forget Me Pill, La Rocha, Lunch Money Drug, Mexican Valium
Pregnancy; category	AU: C ; ;
Addiction; liability	High
Routes of; administration	By mouth
Legal status
Legal status	AU: S8 (Controlled) ; CA: Schedule I ; DE: Anlage III (Prescription only) ; UK: Class C ; US: Schedule IV ; UN: Psychotropic Schedule III ;
Pharmacokinetic data
Bioavailability	64–77% (by mouth); 50% (suppository)
Metabolism	Liver
Metabolites	7-aminoflunitrazepam, desmethylflunitrazepam and 3-hydroxydesmethylflunitrazepam
Onset of action	Rapid
Elimination half-life	18–26 hours
Excretion	Kidney
Identifiers
	IUPAC name 5-(2-fluorophenyl)-1-methyl-7-nitro-1H-benzo[e][1,4]diazepin-2(3H)-one;
ECHA InfoCard	100.015.089
Chemical and physical data
Formula	C16H12FN3O3
Molar mass	୩୧୩.୨୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [O-][N+](C1=CC2=C(C=C1)N(C)C(CN=C2C3=CC=CC=C3F)=O)=O;
	InChI InChI=1S/C16H12FN3O3/c1-19-14-7-6-10(20(22)23)8-12(14)16(18-9-15(19)21)11-4-2-3-5-13(11)17/h2-8H,9H2,1H3 ; Key:PPTYJKAXVCCBDU-UHFFFAOYSA-N ;
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ଫ୍ଲୁନିଟ୍ରାଜେପାମ, ଅନ୍ୟ ନାମମାନଙ୍କ ମଧ୍ୟରେ ରୋହିପ୍ନୋଲ୍ ଭାବରେ ମଧ୍ୟ ଜଣାଶୁଣା, ଏକ ବେଞ୍ଜୋଡାଏଜେପିନ ଯାହା ନିଦ୍ରାହୀନତା ଏବଂ ନିଶ୍ଚେତକ ଦେବାରେ ସାହାଯ୍ୟ କରିଥାଏ ।^[୧] ^[୪] ଏହା ପ୍ରାରମ୍ଭିକ ସୁପାରିଶ କରାଯାଇଥିବା ଚିକିତ୍ସା ନୁହେଁ ଏବଂ କେବଳ ସ୍ୱଳ୍ପକାଳୀନ ବ୍ୟବହାର ପାଇଁ ସୁପାରିଶ କରାଯାଏ ।^[୧] ^[୫]

ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅପବ୍ୟବହାର ସଙ୍କଟ, ରାତି ସମୟ ଖାଇବା, ଦ୍ୱନ୍ଦ୍ୱ ଏବଂ ପ୍ରତ୍ୟାହାର ଲକ୍ଷଣ ଅନ୍ତର୍ଭୁକ୍ତ ଯଦି ଦୀର୍ଘକାଳୀନ ବ୍ୟବହାର ପରେ ହଠାତ୍ ବନ୍ଦ କରିଦିଆଯାଏ । ^[୧] ^[୬] ^[୭] ଅଧିକ ମାତ୍ରା ସେବନ କଲେ ଶ୍ୱାସ କ୍ରିୟା ହ୍ରାସ ହେବା ଏବଂ ମୃତ୍ୟୁ ହୋଇପାରେ ।^[୭] ଦୀର୍ଘ ସମୟ ବ୍ୟବହାର କରିବା ପରେ ଧୀରେ ଧୀରେ ଔଷଧ କମେଇବା ପରେ ବନ୍ଦ କରାଯିବା ଆବଶ୍ୟକ। ^[୭]

ଫ୍ଲୁନିଟ୍ରାଜେପାମ ୧୯୬୨ ମସିହାରେ ପ୍ୟାଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୭୪ରେ ଚିକିତ୍ସା ବ୍ୟବହାରରେ ଆସିଥିଲା ।^[୮] ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ର, ଅଷ୍ଟ୍ରେଲିଆ ଏବଂ ନ୍ୟୁଜିଲ୍ୟାଣ୍ଡରେ ଆଇନଗତ ଭାବରେ ଉପଲବ୍ଧ ନୁହେଁ ଏବଂ ୟୁରୋପର କିଛି ଅଂଶରେ ଏହା ସୀମିତ ଅଟେ । ^[୬] ଏହାକୁ ଏକ ସମ୍ପର୍କ ବଳାତ୍କାର ଔଷଧ ବୋଲି କୁହାଯାଇଛି, ^[୯] ^[୧୦] ଯଦିଓ ଏଥିରେ ସମ୍ପୃକ୍ତ ବଳାତ୍କାର ମାମଲାର ରିପୋର୍ତ ବ‌ହୁତ କମ୍ । ^[୧୧]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Prescribing of Benzodiazepines Alprazolam and Flunitrazepam" (PDF). Pharmaceutical Services Branch. New South Wales Health. November 2013. Archived (PDF) from the original on October 20, 2020. Retrieved October 4, 2020.
↑ Drugs.com International brands for Flunitrazepam Archived September 18, 2020, at the Wayback Machine. Page accessed April 13, 2016
↑ "Rohypnol" (PDF). DEA. Archived (PDF) from the original on October 20, 2020. Retrieved 7 October 2020.
↑ Gahlinger, Paul (2003). Illegal Drugs (in ଇଂରାଜୀ). Penguin. p. 279. ISBN 978-1-4406-5024-6. Archived from the original on August 28, 2021. Retrieved October 7, 2020.
↑ Muir-Cochrane, Eimear; Barkway, Patricia; Nizette, Debra (2014). Mosby's Pocketbook of Mental Health - E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 99. ISBN 978-0-7295-8224-7. Archived from the original on August 28, 2021. Retrieved October 7, 2020.
↑ ^୬.୦ ^୬.୧ Aronson, Jeffrey K. (2016). Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (in ଇଂରାଜୀ). Elsevier. p. 364. ISBN 978-0-444-53716-4. Archived from the original on August 28, 2021. Retrieved October 7, 2020.
↑ ^୭.୦ ^୭.୧ ^୭.୨ Ignatavicius, Donna D.; Workman, M. Linda; Winkelman, Chris (2012). Clinical Companion for Medical-Surgical Nursing - E-Book: Patient-Centered Collaborative Care (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 81. ISBN 978-1-4557-7257-5. Archived from the original on August 28, 2021. Retrieved October 7, 2020.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 53X. ISBN 9783527607495. Archived from the original on August 28, 2021. Retrieved October 4, 2020.
↑ Schwartz, R. H.; Milteer, R.; LeBeau, M. A. (June 2000). "Drug-facilitated sexual assault ('date rape')". Southern Medical Journal. 93 (6): 558–561. doi:10.1097/00007611-200093060-00002. ISSN 0038-4348. PMID 10881768.
↑ Gautam, Lata; Sharratt, Sarah D.; Cole, Michael D. (2014-02-19). "Drug Facilitated Sexual Assault: Detection and Stability of Benzodiazepines in Spiked Drinks Using Gas Chromatography-Mass Spectrometry". PLOS ONE. 9 (2): e89031. Bibcode:2014PLoSO...989031G. doi:10.1371/journal.pone.0089031. ISSN 1932-6203. PMC 3929633. PMID 24586489.{{cite journal}}: CS1 maint: unflagged free DOI (link)
↑ European Monitoring Centre for Drugs and Drug Addiction Benzodiazepines drug profile Archived February 27, 2020, at the Wayback Machine..

[NSW-PSB-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Prescribing of Benzodiazepines Alprazolam and Flunitrazepam" (PDF). Pharmaceutical Services Branch. New South Wales Health. November 2013. Archived (PDF) from the original on October 20, 2020. Retrieved October 4, 2020.

[generics-2] Drugs.com International brands for Flunitrazepam Archived September 18, 2020, at the Wayback Machine. Page accessed April 13, 2016

[DEA2020-3] "Rohypnol" (PDF). DEA. Archived (PDF) from the original on October 20, 2020. Retrieved 7 October 2020.

[Gah2003-4] Gahlinger, Paul (2003). Illegal Drugs (in ଇଂରାଜୀ). Penguin. p. 279. ISBN 978-1-4406-5024-6. Archived from the original on August 28, 2021. Retrieved October 7, 2020.

[Mu2014-5] Muir-Cochrane, Eimear; Barkway, Patricia; Nizette, Debra (2014). Mosby's Pocketbook of Mental Health - E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 99. ISBN 978-0-7295-8224-7. Archived from the original on August 28, 2021. Retrieved October 7, 2020.

[Mey2016-6] ୬.୦ ^୬.୧ Aronson, Jeffrey K. (2016). Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (in ଇଂରାଜୀ). Elsevier. p. 364. ISBN 978-0-444-53716-4. Archived from the original on August 28, 2021. Retrieved October 7, 2020.

[Ig2012-7] ୭.୦ ^୭.୧ ^୭.୨ Ignatavicius, Donna D.; Workman, M. Linda; Winkelman, Chris (2012). Clinical Companion for Medical-Surgical Nursing - E-Book: Patient-Centered Collaborative Care (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 81. ISBN 978-1-4557-7257-5. Archived from the original on August 28, 2021. Retrieved October 7, 2020.

[Fis2006-8] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 53X. ISBN 9783527607495. Archived from the original on August 28, 2021. Retrieved October 4, 2020.

[9] Schwartz, R. H.; Milteer, R.; LeBeau, M. A. (June 2000). "Drug-facilitated sexual assault ('date rape')". Southern Medical Journal. 93 (6): 558–561. doi:10.1097/00007611-200093060-00002. ISSN 0038-4348. PMID 10881768.

[10] Gautam, Lata; Sharratt, Sarah D.; Cole, Michael D. (2014-02-19). "Drug Facilitated Sexual Assault: Detection and Stability of Benzodiazepines in Spiked Drinks Using Gas Chromatography-Mass Spectrometry". PLOS ONE. 9 (2): e89031. Bibcode:2014PLoSO...989031G. doi:10.1371/journal.pone.0089031. ISSN 1932-6203. PMC 3929633. PMID 24586489.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[EU-11] European Monitoring Centre for Drugs and Drug Addiction Benzodiazepines drug profile Archived February 27, 2020, at the Wayback Machine..

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