ଫେକ୍ସୋଫେନାଡାଇନ

ଫେକ୍ସୋଫେନାଡାଇନ
Clinical data
Trade names	Allegra, FX 24, others
AHFS/Drugs.com	monograph
MedlinePlus	a697035
data	EU EMA: yes; US DailyMed: Fexofenadine;
Pregnancy; category	AU: B2 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S2 (Pharmacy only) ; CA: OTC ; UK: POM (Prescription only) ; US: OTC / Rx-only;
Pharmacokinetic data
Bioavailability	30-41%
Protein binding	60-70%
Metabolism	Liver (≤5% of dose)
Onset of action	< 3 hrs
Elimination half-life	14.4 hours
Duration of action	12 hrs
Excretion	Feces (~80%) and urine (~10%) as unchanged drug
Identifiers
	IUPAC name (±)-4-[1-Hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-butyl]-α, α-dimethyl benzeneacetic acid;
ECHA InfoCard	100.228.648
Chemical and physical data
Formula	C32H39NO4
Molar mass	୫୦୧.୬୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)C(c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4)(C)C;
	InChI InChI=1S/C32H39NO4/c1-31(2,30(35)36)25-17-15-24(16-18-25) 29(34)14-9-21-33-22-19-28(20-23-33)32(37, 26-10-5-3-6-11-26)27-12-7-4-8-13-27/h3-8, 10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36) ; Key:RWTNPBWLLIMQHL-UHFFFAOYSA-N ;
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ଫେକ୍ସୋଫେନାଡାଇନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଆଲେଗ୍ରା, ହେଉଛି ଏକ ଆଣ୍ଟିହିଷ୍ଟାମିନ ଔଷଧ ହେ ଫିଭର ଏବଂ ଅର୍ଟିକାରିଆ ଭଳି ଆଲର୍ଜି ଲକ୍ଷଣମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୭] ^[୮] ଏହା ପାଟିରେଦ୍ୱାରା ନିଆଯାଏ | ^[୯] ପ୍ରଭାବ ସାଧାରଣତ ୩ ଘଣ୍ଟା ମଧ୍ୟରେ ଆରମ୍ଭ ହୁଏ ଏବଂ ପ୍ରାୟ ୧୨ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ | ^[୬]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ ଭାବ, ମୁଣ୍ଡବିନ୍ଧା, ବାନ୍ତି, ଏବଂ ମୁଣ୍ଡ ବୁଲାଇବା ହୋଇପାରେ | ^[୭] ପ୍ରଥମ ଜେନେରେସନର ଆଣ୍ଟିହାଇଷ୍ଟାମାଇନ୍ ଅପେକ୍ଷା ଏଥିରେ କମ ନିଦ୍ରା ହୁଏ | ^[୯] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ | ^[୬] ଏହା ଦ୍ୱିତୀୟ ପିଢ଼ୀର ଆଣ୍ଟିହିଷ୍ଟିମିନ ଭାବରେ ଶ୍ରେଣୀଭୁକତ ହୋଇଛି ଏବଂ ଏକ ଚୟନକାରୀ ଏଚ୧-ବ୍ଲକର (H1- ବ୍ଲକର୍) ଭାବରେ କାର୍ଯ୍ୟ କରେ | ^[୬]

ଫେକ୍ସୋଫେନାଡାଇନ ୧୯୭୯ ମସିହାରେ ପେଟେଣ୍ଟ୍ ହୋଇଥିଲା ଏବଂ ୧୯୯୬ ମସିହାରେ ଡାକ୍ତରୀ ବ୍ୟବହାରରେ ଆସିଥିଲା |^[୧୦] ୨୦୧୧ଠାରୁ ଏହା ଏକ ଜେନେରିକ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ହେଲା । ^[୧୧] | ଯୁକ୍ତରାଜ୍ୟରେ ୩୦ ଟାବଲେଟକୁ ପ୍ରାୟ ୨ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରୁଥିବାବେଳେ ୨୦୨୦ ମସିହାରେ ଆମେରିକାରେ ଏହି ରାଶି ପ୍ରାୟ ୯ ଡଲାର ଥିଲା ।^[୧୨] ^[୭] ୨୦୧୭ ମସିହାରେ ଏହା ୨୪୫ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ୍ ଔଷଧ ଥିଲା ଯାହା ଏକ ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ଥିଲା | ^[୧୩] ^[୧୪]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Fexofenadine Use During Pregnancy". Drugs.com. 1 April 2019. Archived from the original on 26 July 2020. Retrieved 26 July 2020.
↑ "Fexofenadine - international brand names". Drugs.com. Archived from the original on 21 April 2021. Retrieved 18 January 2017.
↑ "Fexofenadine hydrochloride 180mg film-coated Tablets - Summary of Product Characteristics (SmPC)". (emc). 26 September 2018. Archived from the original on 26 July 2020. Retrieved 26 July 2020.
↑ ^୪.୦ ^୪.୧ ^୪.୨ Smith, SM; Gums, JG (July 2009). "Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders". Expert Opinion on Drug Metabolism & Toxicology. 5 (7): 813–22. doi:10.1517/17425250903044967. PMID 19545214. S2CID 19048690.
↑ Lappin G, Shishikura Y, Jochemsen R, Weaver RJ, Gesson C, Houston B, Oosterhuis B, Bjerrum OJ, Rowland M, Garner C (May 2010). "Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability". Eur J Pharm Sci. 40 (2): 125–31. doi:10.1016/j.ejps.2010.03.009. PMID 20307657.
↑ ^୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ ^୬.୪ "Fexofenadine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 June 2020. Retrieved 10 November 2020.
↑ ^୭.୦ ^୭.୧ ^୭.୨ BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 288. ISBN 9780857113658.
↑ Bachert, C (May 2009). "A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis". Clin Ther. 31 (5): 921–44. doi:10.1016/j.clinthera.2009.05.017. PMID 19539095.
↑ ^୯.୦ ^୯.୧ "Fexofenadine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 June 2020. Retrieved 10 November 2020.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 548. ISBN 9783527607495. Archived from the original on 2020-08-13. Retrieved 2020-07-26.
↑ "Dr. Reddy's announces the launch of Over-the-Counter Fexofenadine HCl and Pseudoephedrine HCl extended release tablets". Dr. Reddy's Laboratories Ltd. 30 August 2011. Archived from the original on 12 October 2016. Retrieved 27 May 2016.
↑ "Compare Fexofenadine Prices". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Archived from the original on 22 April 2020. Retrieved 10 November 2020.
↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
↑ "Fexofenadine Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ "Fexofenadine Use During Pregnancy". Drugs.com. 1 April 2019. Archived from the original on 26 July 2020. Retrieved 26 July 2020.

[Brands-2] "Fexofenadine - international brand names". Drugs.com. Archived from the original on 21 April 2021. Retrieved 18 January 2017.

[3] "Fexofenadine hydrochloride 180mg film-coated Tablets - Summary of Product Characteristics (SmPC)". (emc). 26 September 2018. Archived from the original on 26 July 2020. Retrieved 26 July 2020.

[phk09-4] ୪.୦ ^୪.୧ ^୪.୨ Smith, SM; Gums, JG (July 2009). "Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders". Expert Opinion on Drug Metabolism & Toxicology. 5 (7): 813–22. doi:10.1517/17425250903044967. PMID 19545214. S2CID 19048690.

[5] Lappin G, Shishikura Y, Jochemsen R, Weaver RJ, Gesson C, Houston B, Oosterhuis B, Bjerrum OJ, Rowland M, Garner C (May 2010). "Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability". Eur J Pharm Sci. 40 (2): 125–31. doi:10.1016/j.ejps.2010.03.009. PMID 20307657.

[AHFS2020-6] ୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ ^୬.୪ "Fexofenadine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 June 2020. Retrieved 10 November 2020.

[BNF79-7] ୭.୦ ^୭.୧ ^୭.୨ BNF 79 : March 2020. London: Royal Pharmaceutical Society. 2020. p. 288. ISBN 9780857113658.

[8] Bachert, C (May 2009). "A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis". Clin Ther. 31 (5): 921–44. doi:10.1016/j.clinthera.2009.05.017. PMID 19539095.

[autogen1-9] ୯.୦ ^୯.୧ "Fexofenadine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 June 2020. Retrieved 10 November 2020.

[Fis2006-10] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 548. ISBN 9783527607495. Archived from the original on 2020-08-13. Retrieved 2020-07-26.

[11] "Dr. Reddy's announces the launch of Over-the-Counter Fexofenadine HCl and Pseudoephedrine HCl extended release tablets". Dr. Reddy's Laboratories Ltd. 30 August 2011. Archived from the original on 12 October 2016. Retrieved 27 May 2016.

[GX2020-12] "Compare Fexofenadine Prices". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Archived from the original on 22 April 2020. Retrieved 10 November 2020.

[ref-13] "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.

[ref1-14] "Fexofenadine Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

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