ପାପାଭେରିନ

ପାପାଭେରିନ
Clinical data
Pronunciation	/pəˈpævəriːn/
Trade names	Pavabid, others
AHFS/Drugs.com	monograph
MedlinePlus	a682707
Pregnancy; category	AU: A ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth, intravenous, intramuscular, rectal, intracavernosal
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	80%
Protein binding	~90%
Metabolism	Liver
Elimination half-life	1.5–2 hours
Excretion	Kidney
Identifiers
	IUPAC name 1-(3,4-Dimethoxybenzyl)-7,8-dimethoxyisoquinoline;
ECHA InfoCard	100.000.361
Chemical and physical data
Formula	C20H21NO4
Molar mass	୩୩୯.୩୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc1ccc(cc1OC)Cc2c3cc(c(cc3ccn2)OC)OC;
	InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3 ; Key:XQYZDYMELSJDRZ-UHFFFAOYSA-N ;
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ପାପାଭେରିନ ହେଉଛି ଏକ ଔଷଧ ଯାହା ମୁଖ୍ୟତଃ ଧମନୀ ସ୍ପାଜ୍ମ ଏବଂ ପୌରୁଷ ଅସାମର୍ଥ୍ୟର (ଇଡି/ED) ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ଏହା ଇଡି ପାଇଁ ପ୍ରଥମ ଲାଇନ ଔଷଧ ନୁହେଁ ।^[୧] ଋତୁଶୂଳ ଏବଂ ପାକ-ଅନ୍ତନଳୀ ସ୍ପାମ୍ ଭଳି ରୋଗ ପାଇଁ ମଧ୍ୟ ବ୍ୟବ‌ହୃତ ହୁଏ ।^[୧] ଏହା ପାଟିରେ କିମ୍ବା ଇଞ୍ଜେକ୍ସନଦ୍ୱାରା ଦିଆଯାଏ ।^[୧] ଆରମ୍ଭ ଅପେକ୍ଷାକୃତ ଶୀଘ୍ର ହୁଏ ଏବଂ ଘଣ୍ଟା ଘଣ୍ଟା ଧରି ରହିଥାଏ ।^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, କୋଷ୍ଠକାଠିନ୍ୟ, ମୁଣ୍ଡବିନ୍ଧା, ପେଟ ଯନ୍ତ୍ରଣା, ଲାଲ ପଡ଼ିବା (ଫ୍ଲଶ୍), ନିମ୍ନ ରକ୍ତଚାପ ଏବଂ ପ୍ରାୟାପିଜ୍ମ ହୋଇପାରେ ।^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶ୍ୱାସକ୍ରିୟା ବନ୍ଦ, ଯକୃତ ସମସ୍ୟା, ଅପବ୍ୟବହାର ଏବଂ ଅନିୟମିତ ହୃତ୍‌ ସ୍ପନ୍ଦନହୋଇପାରେ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ ।^[୨]

ପାପାଭେରିନ ପ୍ରଥମେ ୧୮୪୮ ମସିହାରେ ଅଫିମରୁ ପ୍ରସ୍ତୁତ କରାଯାଇଥିଲା ।^[୩] ଅଫିମରୁ ତିଆରି ହେବା ସତ୍ତ୍ୱେ ଏଥିରେ ଅଫିମ ସମ୍ପର୍କୀୟ କୌଣସି କାର୍ଯ୍ୟକଳାପ ନାହିଁ ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ୬୦ ମିଗ୍ରା ମାତ୍ରାର ମୂଲ୍ୟ ପ୍ରାୟ ୪୦ ଡଲାର ଥିଲା ।^[୫]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Papaverine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 8 June 2021. Retrieved 26 October 2021.
↑ "DailyMed - PAPAVERINE HYDROCHLORIDE injection, solution". dailymed.nlm.nih.gov. Archived from the original on 26 October 2021. Retrieved 26 October 2021.
↑ Hanessian, Stephen (18 December 2013). Natural Products in Medicinal Chemistry (in ଇଂରାଜୀ). John Wiley & Sons. p. 227. ISBN 978-3-527-67655-2. Archived from the original on 26 October 2021. Retrieved 26 October 2021.
↑ Sdrales, Lorraine M.; Miller, Ronald D. (21 May 2012). Miller's Anesthesia Review: Expert Consult - Online and Print (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 66. ISBN 978-1-4377-2793-7. Archived from the original on 26 October 2021. Retrieved 26 October 2021.
↑ "Papaverine Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 31 July 2020. Retrieved 26 October 2021.

[AHFS2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Papaverine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 8 June 2021. Retrieved 26 October 2021.

[PI2021-2] "DailyMed - PAPAVERINE HYDROCHLORIDE injection, solution". dailymed.nlm.nih.gov. Archived from the original on 26 October 2021. Retrieved 26 October 2021.

[3] Hanessian, Stephen (18 December 2013). Natural Products in Medicinal Chemistry (in ଇଂରାଜୀ). John Wiley & Sons. p. 227. ISBN 978-3-527-67655-2. Archived from the original on 26 October 2021. Retrieved 26 October 2021.

[4] Sdrales, Lorraine M.; Miller, Ronald D. (21 May 2012). Miller's Anesthesia Review: Expert Consult - Online and Print (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 66. ISBN 978-1-4377-2793-7. Archived from the original on 26 October 2021. Retrieved 26 October 2021.

[5] "Papaverine Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 31 July 2020. Retrieved 26 October 2021.

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