ପାଙ୍କୁରୋନିଅମ

Pancuronium
Clinical data
Synonyms	Pancuronium bromide
AHFS/Drugs.com	monograph
Pregnancy; category	AU: B2 ; US: C (Risk not ruled out) ;
Routes of; administration	Intravenous
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	NA
Protein binding	77 to 91%
Metabolism	Liver
Onset of action	2 to 3 min
Elimination half-life	1.5 to 2.7 hours
Duration of action	Up to 100 min
Excretion	Kidney and biliary
Identifiers
	IUPAC name [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-Acetyloxy-10,13-dimethyl-2,16-bis(pyridin-1-yl)-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate;
ECHA InfoCard	100.035.923
Chemical and physical data
Formula	C35H60N2O4
Molar mass	୫୭୨.୮୮ g·mol−1
	InChI InChI=1S/C35H60N2O4.2BrH/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36;;/h26-33H,7-23H2,1-6H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1 ; Key:NPIJXCQZLFKBMV-YTGGZNJNSA-L ;
(verify)

ପାଙ୍କୁରୋନିଅମ, ଏକ ବେପାର ନାମ ପାଭୁଲନ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଶାରୀରିକ ନିଶ୍ଚେତକ ଦେବା ସମୟରେ ମାଂସପେଶୀକୁ ଶିଥିଳ କରିବା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ଏବଂ ଏଣ୍ଡୋଟ୍ରାକିଆଲ ଇଣ୍ଟ୍ୟୁବେସନ ସମୟରେ ସାହାଯ୍ୟ କରିବାକୁ ଦିଆଯାଏ ।^[୧] ଏହା ଏକ ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୧] ଔଷଧର ପ୍ରଭାବର ଆରମ୍ଭ ୨ରୁ ୩ ମିନିଟ ମଧ୍ୟରେ ଧୀରେ ଧୀରେ ଆରମ୍ଭ ହୁଏ ଓ ପ୍ରଭାବ ୧୦୦ ମିନିଟ୍ ପର୍ଯ୍ୟନ୍ତ ରହିପାରେ । ^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମାଂସପେଶୀ ଦୁର୍ବଳତା ହୋଇଥାଏ ।^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲକ୍‌ସିସ ଏବଂ ହୃଦସ୍ପନ୍ଦନ ଗତି ବୃଦ୍ଧି ହୋଇପାରେ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ନିରାପଦ ମନେହୁଏ, କିନ୍ତୁ ଭଲ ଭାବରେ ଅଧ୍ୟୟନ କରାଯାଇନାହିଁ ।^[୨] ଏହାର ପ୍ରଭାବକୁ ଓଲଟାଇବା ପାଇଁ ନିଓଷ୍ଟିଗମିନ କିମ୍ବା ପାରିଡୋଷ୍ଟିଗମିନ ବ୍ୟବହାର କରାଯାଇପାରେ ।^[୩] ଏହା ଏକ ନ୍ୟୁରୋମସ୍କୁଲାର ବ୍ଲକିଂ ଏଜେଣ୍ଟ ।^[୩]

ପାଙ୍କୁରୋନିଅମ ପ୍ରଥମେ ୧୯୬୪ ମସିହାରେ ତିଆରି ହୋଇଥିଲା ଏବଂ ୧୯୭୨ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ଅନୁମୋଦନ କରାଯାଇଥିଲା ।^[୧] ^[୩] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରତି ୪ ମିଗ୍ରା ଔଷଧ ପାଇଁ ୫ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୁଏ ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣ ମୂଲ୍ୟ ପ୍ରାୟ ୩ ଡଲାର ଅଟେ।^[୫] ଏହା ଇଉଥାନାସିଆ ଏବଂ ମାରାତ୍ମକ ଇଞ୍ଜେକ୍ସନ ସମୟରେ ବ୍ୟବହୃତ ହୋଇଛି ।^[୬] ^[୭]

ଆଧାର

1 2 3 4 5 6 7 8 "Pancuronium Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 October 2021. Retrieved 26 October 2021.
↑ "Pancuronium (Pavulon) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 November 2020. Retrieved 26 October 2021.
1 2 3 Das GN, Sharma P, Maani CV (January 2021). "Pancuronium". StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID 30855929. Archived from the original on 2021-01-04. Retrieved 2021-08-22.
1 2 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1391. ISBN 978-0857114105.
↑ "Pancuronium Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 10 May 2019. Retrieved 26 October 2021.
↑ "US court backs lethal injection". BBC News. 16 April 2008. Archived from the original on 20 April 2008. Retrieved 22 August 2021.
↑ "Administration and Compounding Of Euthanasic Agents". The Hague: Royal Dutch Society for the Advancement of Pharmacy. Archived from the original on 7 June 2008. Retrieved 15 July 2008 – via ERGO!.

[AHFS2021-1] 1 2 3 4 5 6 7 8 "Pancuronium Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 October 2021. Retrieved 26 October 2021.

[2] "Pancuronium (Pavulon) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 November 2020. Retrieved 26 October 2021.

[Stat2021-3] 1 2 3 Das GN, Sharma P, Maani CV (January 2021). "Pancuronium". StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID 30855929. Archived from the original on 2021-01-04. Retrieved 2021-08-22.

[BNF81-4] 1 2 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1391. ISBN 978-0857114105.

[5] "Pancuronium Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 10 May 2019. Retrieved 26 October 2021.

[BBC2008-6] "US court backs lethal injection". BBC News. 16 April 2008. Archived from the original on 20 April 2008. Retrieved 22 August 2021.

[Ergo2008-7] "Administration and Compounding Of Euthanasic Agents". The Hague: Royal Dutch Society for the Advancement of Pharmacy. Archived from the original on 7 June 2008. Retrieved 15 July 2008 – via ERGO!.

[୧]

[୨]

[୩]

[୪]

[୫]

[୬]

[୭]