ନେଲଫିନାଭିର

ନେଲଫିନାଭିର
Clinical data
Trade names	Viracept
AHFS/Drugs.com	monograph
MedlinePlus	a697034
data	US DailyMed: Nelfinavir;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	Uncertain; increases when taking with food
Protein binding	>98%
Metabolism	Liver by CYP including CYP3A4 and CYP2C19
Elimination half-life	3.5–5 hours
Excretion	feces (87%), urine (1–2%)
Identifiers
	IUPAC name (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylphenyl)formamido]-4-(phenylsulfanyl)butyl]-decahydroisoquinoline-3-carboxamide;
Chemical and physical data
Formula	C32H45N3O4S
Molar mass	୫୬୭.୭୯ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	349.94 °C (661.89 °F)
	SMILES O=C(c1cccc(O)c1C)N[C@@H](CSc2ccccc2)[C@H](O)CN4[C@H](C(=O)NC(C)(C)C)C[C@@H]3CCCC[C@@H]3C4;
	InChI InChI=1S/C32H45N3O4S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39)/t22-,23+,26-,27-,29+/m0/s1 ; Key:QAGYKUNXZHXKMR-HKWSIXNMSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Nelfinavir

ନେଲଫିନାଭିର (ଇଂରାଜୀ ଭାଷାରେ Nelfinavir/ NFV), ଭାଇରାସେପ୍ଟ ଏହାର ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଏଚଆଇଭି/ଏଡସ ରୋଗର ଚିକିତ୍ସା କରିବା ପାଇଁ ବ୍ୟବ‌ହୃତ ହୁଏ ।^[୨] ଏହା ଅନ୍ୟାନ୍ୟ ଔଷଧ ସହିତ ଏକତ୍ର ବ୍ୟବହୃତ ହୁଏ ।^[୨] ଏହା ପ୍ରଥମ ଧାଡ଼ିର ଚିକିତ୍ସା ନୁହେଁ ।^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ଅଇ ଏବଂ ରାସ ହୋଇପାରେ ।^[୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଉଚ୍ଚ ରକ୍ତ ଶର୍କରା ଏବଂ ଶରୀରର ଚର୍ବିରେ ପରିବର୍ତ୍ତନ ହୋଇପାରେ ।^[୨] ଗର୍ଭାବସ୍ଥାରେ କୌଣସି ନିର୍ଦ୍ଦିଷ୍ଟ କ୍ଷତି ନଥିବାବେଳେ ଏହାଠାରୁ ଉନ୍ନତ ବିକଳ୍ପ ଉପଲବ୍ଧ ମିଳୁଛି ।^[୩] ଏହା ଏକ ଏଚ୍.ଆଇ.ଭି ପ୍ରୋଟିଏଜ ଇନହିବିଟର ।^[୨]

ନେଲଫିନାଭିର ୧୯୯୨ ମସିହାରେ ପେଟେଣ୍ଟ ହୋଇଥିଲେ ଏବଂ ୧୯୯୭ରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ୧୯୯୮ରେ ୟୁରୋପରେ ଏହା ଅନୁମୋଦିତ ହୋଇଥିବାବେଳେ ପରେ ଏହାକୁ ପ୍ରତ୍ୟାହାର କରି ନିଆଯାଇଥିଲା ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ଚିକିତ୍ସା ପିଛା ୨୦୨୧ ସୁଦ୍ଧା ମାସକୁ ପ୍ରାୟ ୧୨୦୦ ଡଲାର ଖର୍ଚ୍ଚ ହୁଏ ।^[୬]

ଆଧାର

↑ "Viracept (nelfinavir mesylate) Tablets and Oral Powder, for Oral Use. Full Prescribing Information" (PDF). ViiV Healthcare Company. Research Triangle Park, NC 27709. Archived (PDF) from the original on 4 March 2016. Retrieved 23 November 2015.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Nelfinavir Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 12 November 2021.
↑ "Nelfinavir (Viracept) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 12 November 2021.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 510. ISBN 9783527607495. Archived from the original on 2021-05-24. Retrieved 2021-04-24.
↑ "Viracept". Archived from the original on 23 October 2020. Retrieved 12 November 2021.
↑ "Nelfinavir Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 12 November 2021.

[1] "Viracept (nelfinavir mesylate) Tablets and Oral Powder, for Oral Use. Full Prescribing Information" (PDF). ViiV Healthcare Company. Research Triangle Park, NC 27709. Archived (PDF) from the original on 4 March 2016. Retrieved 23 November 2015.

[AHFS2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Nelfinavir Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 12 November 2021.

[3] "Nelfinavir (Viracept) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 12 November 2021.

[Fis2006-4] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 510. ISBN 9783527607495. Archived from the original on 2021-05-24. Retrieved 2021-04-24.

[5] "Viracept". Archived from the original on 23 October 2020. Retrieved 12 November 2021.

[6] "Nelfinavir Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 12 November 2021.

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