ଏଟିଜୋଲାମ

Etizolam
Clinical data
Trade names	Etizest, Etilaam, Etizex, Depas, Sedekopan, Pasaden, others
Synonyms	Etiz, etizzy
Dependence; liability	Moderate
Routes of; administration	By mouth, under the tongue, rectal
Legal status
Legal status	DE: Anlage III (Prescription only) ; UK: Class C ; US: Unscheduled - Schedule I in Alabama, Arkansas, Florida, Louisiana, Mississippi, Ohio, Oregon, and Virginia; Schedule IV in Georgia, Texas, and South Carolina; scheduled in Arizona and Indiana; not FDA approved. ; UN: Psychotropic Schedule IV ;
Pharmacokinetic data
Bioavailability	93%
Metabolism	Liver
Elimination half-life	3.4 hours (main metabolite is 8.2 hours)
Duration of action	5-7 hours
Excretion	Kidney
Identifiers
	IUPAC name 4-(2-Chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine;
ECHA InfoCard	100.188.773
Chemical and physical data
Formula	C17H15ClN4S
Molar mass	୩୪୨.୮୫ g·mol−1
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ଏ

ଏଟିଜୋଲାମ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଡିପାସ୍, ହେଉଛି ଏକ ଔଷଦ ଯାହା ସାଧାରଣ ଉତ୍କଣ୍ଠା ବ୍ୟାଧି, ଆତଙ୍କିତ ବ୍ୟାଧି (ପ୍ୟାନିକ ଡିଜଅର୍ଡ଼ର) ଏବଂ ଅନିଦ୍ରା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ^[୮] ଏହା ସ୍ୱଳ୍ପ ମିଆଦି ବ୍ୟବହୃତ ହୋଇପାରେ କିନ୍ତୁ ବେଞ୍ଜୋଡାଏଜେପିନ୍ ଅପେକ୍ଷା ଭଲ କାମ କରେ ନାହିଁ ।^[୯] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୧]

ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ, ମାଂସପେଶୀ ଦୁର୍ବଳତା, ସମନ୍ୱୟ ଅଭାବ, ଚେତା ହରେଇବା, ମୁଣ୍ଡବିନ୍ଧା, ଦ୍ୱନ୍ଦ୍ୱ, ଥଙ୍ଗେଇ କଥାବାର୍ତ୍ତା ଏବଂ ଯୌନ ଅସୁବିଧା ହୋଇପାରେ ।^[୮] ଅପବ୍ୟବହାର ଏବଂ ନିର୍ଭରଶୀଳତାର ଆଶଙ୍କା ମଧ୍ୟ ଅଛି ।^[୮] ଏହା ଏକ ପ୍ରକାର ଥିଏନୋଡାଏଜେପିନ୍, ଯାହା ବେଞ୍ଜୋଡାଏଜେପିନ ସହିତ ସମତୁଲ ।^[୮] ଏହା ଜିଏବିଏ<sub id="mwLg">ଏ</sub> (GABA <sub id="mwLg">A</sub>) ରିସେପ୍ଟରର ବେଞ୍ଜୋଡାଏଜେପିନ ସ୍ଥାନ ମାଧ୍ୟମରେ କାର୍ଯ୍ୟ କରେ ।^[୧] ଏଥିରେ ଉତ୍କଣ୍ଠା କମ କରିବା, ବାତ ବିରୋଧୀ, ପ୍ରଶାନ୍ତି କାରକ, ନିଦ୍ରାକାରକ ଏବଂ ସ୍ୱେଚ୍ଛାକୃତ (କଙ୍କାଳ) ମାଂସପେଶୀ - ଆରାମଦାୟକ ପ୍ରଭାବ ରହିଛି ।^[୮]

ଇଟିଜୋଲାମ ୧୯୭୧ମସିହାରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୮୪ ମସିହାରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୧୦] ^[୮] ୨୦୨୦ ସୁଦ୍ଧା ଏହା ଜାପାନ, ଇଟାଲୀ ଏବଂ ଭାରତରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା କିନ୍ତୁ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ନୁହେଁ ।^[୧] ^[୮] ୟୁରୋପ ଏବଂ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଅପବ୍ୟବହାର ବୃଦ୍ଧି ନେଇ ଚିନ୍ତା ପ୍ରକଟ କରାଯାଇଛି। ^[୧] ଏହା ଏଟିଜ୍ ଏବଂ ଏଟିଜି ନାକମ ରାସ୍ତା ନାମ ସହିତ ମଧ୍ୟ ଜଣାଶୁଣା | ^[୧]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ ^୧.୭ "Etizolam (INN)" (PDF). WHO. November 2015. Archived (PDF) from the original on 11 July 2021. Retrieved 15 August 2021.
↑ "Controlled Substance Schedule | SCDHEC". www.scdhec.gov. Archived from the original on 2019-03-30. Retrieved 2019-03-20.
↑ "Arizona HB2033 | 2017 | Fifty-third Legislature 1st Regular". LegiScan. Archived from the original on 2020-11-17. Retrieved 2021-08-04.
↑ "Ellington's bill banning two deadly drugs could soon be law - State of Indiana House of Representatives". www.indianahouserepublicans.com. Archived from the original on 2020-11-17. Retrieved 2021-08-04.
↑ "Etizolam". www.drugbank.ca. Archived from the original on 2020-03-06. Retrieved 2020-09-03.
↑ U.S. Drug Enforcement Administration (March 2020). "Drug & Chemical Evaluation - Etizolam" (PDF). U.S. Department of Justice. Archived (PDF) from the original on September 2020. {{cite web}}: Check date values in: |archive-date= (help)
↑ Fracasso, C.; Confalonieri, S.; Garattini, S.; Caccia, S. (1991-02-01). "Single and multiple dose pharmacokinetics of etizolam in healthy subjects". European Journal of Clinical Pharmacology (in ଇଂରାଜୀ). 40 (2): 181–185. doi:10.1007/BF00280074 (inactive 31 May 2021). ISSN 1432-1041. PMID 2065698. Archived from the original on 2017-05-19. Retrieved 2021-08-04.{{cite journal}}: CS1 maint: DOI inactive as of ମଇ 2021 (link)
↑ ^୮.୦ ^୮.୧ ^୮.୨ ^୮.୩ ^୮.୪ ^୮.୫ ^୮.୬ "Etizolam" (PDF). Drug Enforcement Administration. March 2020. Archived from the original (PDF) on 3 September 2020. Retrieved 16 August 2021.
↑ Tripathi, K. D. (31 October 2018). Essentials of Medical Pharmacology (in ଇଂରାଜୀ). Jaypee Brothers Medical Publishers. p. 433. ISBN 978-93-5270-499-6. Archived from the original on 28 August 2021. Retrieved 16 August 2021.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 536. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2021-08-04. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[WHO2015-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ ^୧.୭ "Etizolam (INN)" (PDF). WHO. November 2015. Archived (PDF) from the original on 11 July 2021. Retrieved 15 August 2021.

[scdhec-2] "Controlled Substance Schedule | SCDHEC". www.scdhec.gov. Archived from the original on 2019-03-30. Retrieved 2019-03-20.

[3] "Arizona HB2033 | 2017 | Fifty-third Legislature 1st Regular". LegiScan. Archived from the original on 2020-11-17. Retrieved 2021-08-04.

[indianahouserepublicans.com-4] "Ellington's bill banning two deadly drugs could soon be law - State of Indiana House of Representatives". www.indianahouserepublicans.com. Archived from the original on 2020-11-17. Retrieved 2021-08-04.

[auto-5] "Etizolam". www.drugbank.ca. Archived from the original on 2020-03-06. Retrieved 2020-09-03.

[DEADiv-etiz-factsheet-6] U.S. Drug Enforcement Administration (March 2020). "Drug & Chemical Evaluation - Etizolam" (PDF). U.S. Department of Justice. Archived (PDF) from the original on September 2020. {{cite web}}: Check date values in: |archive-date= (help)

[auto1-7] Fracasso, C.; Confalonieri, S.; Garattini, S.; Caccia, S. (1991-02-01). "Single and multiple dose pharmacokinetics of etizolam in healthy subjects". European Journal of Clinical Pharmacology (in ଇଂରାଜୀ). 40 (2): 181–185. doi:10.1007/BF00280074 (inactive 31 May 2021). ISSN 1432-1041. PMID 2065698. Archived from the original on 2017-05-19. Retrieved 2021-08-04.{{cite journal}}: CS1 maint: DOI inactive as of ମଇ 2021 (link)

[DEA2020-8] ୮.୦ ^୮.୧ ^୮.୨ ^୮.୩ ^୮.୪ ^୮.୫ ^୮.୬ "Etizolam" (PDF). Drug Enforcement Administration. March 2020. Archived from the original (PDF) on 3 September 2020. Retrieved 16 August 2021.

[Tri2018-9] Tripathi, K. D. (31 October 2018). Essentials of Medical Pharmacology (in ଇଂରାଜୀ). Jaypee Brothers Medical Publishers. p. 433. ISBN 978-93-5270-499-6. Archived from the original on 28 August 2021. Retrieved 16 August 2021.

[Fis2006-10] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 536. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2021-08-04. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

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