ଆର୍ଟିକେନ

ଆର୍ଟିକେନ
Clinical data
Trade names	Septocaine, Ultracain, others
Synonyms	Carticaine, articaine hydrochloride/epinephrine
AHFS/Drugs.com	monograph
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	Subcutaneous
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Metabolism	Liver, plasma
Onset of action	Within 6 min
Elimination half-life	30 min
Duration of action	1 hr
Excretion	Liver and unspecific plasma estearases
Identifiers
	IUPAC name (RS)-Methyl 4-methyl-3-(2-propylaminopropanoylamino)thiophene-2-carboxylate;
ECHA InfoCard	100.115.711
Chemical and physical data
Formula	C13H20N2O3S
Molar mass	284.37 g/mol; 320.836 g/mol (HCl)
3D model (JSmol)	Interactive image;
	SMILES O=C(Nc1c(scc1C)C(=O)OC)C(NCCC)C;
	InChI InChI=1S/C13H20N2O3S/c1-5-6-14-9(3)12(16)15-10-8(2)7-19-11(10)13(17)18-4/h7,9,14H,5-6H2,1-4H3,(H,15,16) ; Key:QTGIAADRBBLJGA-UHFFFAOYSA-N ;
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ଆର୍ଟିକେନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ସେପ୍ଟୋକେନ ,ହେଉଛି ଏକ ସ୍ଥାନୀୟ ନିଶ୍ଚେତକ ଯାହା ଅନୁଭବ ହ୍ରାସ କରିବା ପାଇଁ ଏକ ଅଞ୍ଚଳରେ ଇଞ୍ଜେକ୍ସନ ଆକାରରେ ଦିଆଯାଏ । ^[୧] ଏହା ଏକ ସ୍ନାୟୁ ଅବରୋଧୀ ଯାହା କ୍ଷେତ୍ର ଯୋଗାଇଥିବା ଏକ ସ୍ନାୟୁ ଚାରିପାଖରେ ଇଞ୍ଜେକ୍ସନ ଆକାରରେ ଦିଆଯାଏ ।^[୧] ଏହାର କାର୍ଯ୍ୟର ଅବଧି ବଢ଼ାଇବା ପାଇଁ ଅଳ୍ପ ପରିମାଣର ଏପିନେଫ୍ରାଇନ୍ ସହିତ ମିଶ୍ରିତ ଉପଲବ୍ଧ ହୁଏ ।^[୧] ଏହାର ପ୍ରଭାବ ଆରମ୍ଭ ୬ ମିନିଟ୍ ମଧ୍ୟରେ ହୁଏ ଏବଂ ପ୍ରାୟ ଏକ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ । ^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା ଏବଂ ଯନ୍ତ୍ରଣା ଅନ୍ତର୍ଭୁକ୍ତ । ^[୩] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାତ ଏବଂ ମେଥେମୋଗ୍ଲୋବିନେମିଆ ହୋଇପାରେ। ^[୩] ଗର୍ଭଧାରଣ ଏବଂ ସ୍ତନ୍ୟପାନରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ। ^[୪] ଏହା ଏକ ପ୍ରକାର ଆମିଡ୍ । ^[୩]

ଆର୍ଟିକେନ ୧୯୭୬ ମସିହାରେ ୟୁରୋପରେ, ୧୯୮୩ରେ କାନାଡାରେ ଏବଂ ୨୦୦୦ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟବହାରରେ ଆସିଥିଲା । ^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ୫୦ ମାତ୍ରାର ମୂଲ୍ୟ ୨୫ ପାଉଣ୍ଡ ଅଟେ । ^[୬] ଏହା ଅନେକ ୟୁରୋପୀୟ ଦେଶରେ ବହୁଳ ଭାବରେ ବ୍ୟବହୃତ ହୁଏ । ^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Articaine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 7 November 2021. Retrieved 16 January 2022.
↑ Oertel R, Ebert U, Rahn R, Kirch W. Clinical pharmacokinetics of articaine. Clin Pharmacokinet. 1997 Dec;33(6):421
↑ ^୩.୦ ^୩.୧ ^୩.୨ "DailyMed - ARTICAINE- articaine hydrochloride and epinephrine injection, solution". dailymed.nlm.nih.gov. Archived from the original on 19 March 2021. Retrieved 16 January 2022.
↑ "Articaine / epinephrine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 December 2020. Retrieved 16 January 2022.
↑ Malamed, Stanley F. (25 April 2014). Handbook of Local Anesthesia - E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 66. ISBN 978-0-323-24202-8. Archived from the original on 16 January 2022. Retrieved 16 January 2022.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1403. ISBN 978-0857114105.
↑ Oertel, R; Rahn, R; Kirch, W (December 1997). "Clinical pharmacokinetics of articaine". Clinical pharmacokinetics. 33 (6): 417–25. doi:10.2165/00003088-199733060-00002. PMID 9435991.

[AHFS2022-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Articaine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 7 November 2021. Retrieved 16 January 2022.

[2] Oertel R, Ebert U, Rahn R, Kirch W. Clinical pharmacokinetics of articaine. Clin Pharmacokinet. 1997 Dec;33(6):421

[PI2022-3] ୩.୦ ^୩.୧ ^୩.୨ "DailyMed - ARTICAINE- articaine hydrochloride and epinephrine injection, solution". dailymed.nlm.nih.gov. Archived from the original on 19 March 2021. Retrieved 16 January 2022.

[4] "Articaine / epinephrine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 December 2020. Retrieved 16 January 2022.

[5] Malamed, Stanley F. (25 April 2014). Handbook of Local Anesthesia - E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 66. ISBN 978-0-323-24202-8. Archived from the original on 16 January 2022. Retrieved 16 January 2022.

[BNF81-6] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1403. ISBN 978-0857114105.

[7] Oertel, R; Rahn, R; Kirch, W (December 1997). "Clinical pharmacokinetics of articaine". Clinical pharmacokinetics. 33 (6): 417–25. doi:10.2165/00003088-199733060-00002. PMID 9435991.

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