ଆଇଡେଲାଲିସିବ

ଆଇଡେଲାଲିସିବ
	Idelalisib structure
Clinical data
Pronunciation	/aɪˈdɛləlɪsɪb/; eye-DEL-ə-LI-sib
Trade names	Zydelig
Synonyms	GS-1101, CAL-101
AHFS/Drugs.com	monograph
MedlinePlus	a614040
data	EU EMA: yes;
Pregnancy; category	AU: D ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth (tablets)
Legal status
Legal status	US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Protein binding	>84%
Metabolism	Aldehyde oxidase (~70%), CYP3A4 (~30%); UGT1A4 (minor)
Metabolites	GS-563117 (inactive in vitro)
Onset of action	Tmax = 1.5 hours
Elimination half-life	8.2 hours
Excretion	Feces (78%), urine (14%)
Identifiers
	IUPAC name 5-Fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]-4(3H)-quinazolinone;
ECHA InfoCard	100.235.089
Chemical and physical data
Formula	C22H18FN7O
Molar mass	୪୧୫.୪୩ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC[C@H](Nc1ncnc2nc[nH]c12)c4nc3cccc(F)c3c(=O)n4c5ccccc5;
	InChI InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1; Key:IFSDAJWBUCMOAH-HNNXBMFYSA-N;

ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Idelalisib

ଆଇଡେଲାଲିସିବ (ଇଂରାଜୀ ଭାଷାରେ Idelalisib), ଜାଇଡେଲିଗ ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା କ୍ରନିକ ଲିମ୍ଫୋସାଇଟିକ ଲିଉକେମିଆ (CLL), ଫୋଲିକୁଲାର୍ ଲିମ୍ଫୋମା ଏବଂ ଛୋଟ ଲିମ୍ଫୋସାଇଟିକ ଲିମ୍ଫୋମା (SLL) ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୩] ^[୧] ଯେତେବେଳେ ଅନ୍ୟ ଚିକିତ୍ସା ବିଫଳ ହୁଏ କିମ୍ବା ଉପଯୁକ୍ତ ନୁହେଁ ସେତେବେଳେ ଏହା ବ୍ୟବହୃତ ହୁଏ ।^[୩] ^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସଂକ୍ରମଣ, ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତ କଣିକା, ତରଳ ଝାଡ଼ା, ଯକୃତ ସମସ୍ୟା, ରାସ, ଜ୍ୱର ହୋଇପାରେ ।^[୧] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ହୋଇପାରେ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି କରିପାରେ ।^[୩] ଏହା ଏକ ଫସଫୋଇନୋସାଇଟାଇଡ୍ ୩-କାଇନେଜ ଇନହିବିଟର ଯାହା ପିଆଇ୩କେଓକୁ (PI3Kδ) ଅବରୋଧ କରିଥାଏ ।^[୫] ^[୧]

୨୦୧୪ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବ‌ହାର ପାଇଁ ଆଇଡେଲାଲିସିବ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ^[୧] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ଏହାର ଏକ ମାସର ଚିକିତ୍ସା ପାଇଁ ପ୍ରାୟ ୩,୧୦୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହେଉଥିଲା ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୧୨,୩୦୦ ଡଲାର ଅଟେ ।^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Zydelig EPAR". European Medicines Agency (EMA). Archived from the original on 23 October 2020. Retrieved 21 October 2020.
↑ "Clinical Pharmacology and Biopharmaceutics Review: Zydelig (idelalisib)" (PDF). U.S. Food and Drug Administration. p. 6. Archived (PDF) from the original on 28 April 2016. Retrieved 15 April 2016.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Zydelig- idelalisib tablet, film coated". DailyMed. 22 October 2018. Archived from the original on 23 October 2020. Retrieved 21 October 2020.
↑ ^୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1029. ISBN 978-0857114105.
↑ ^୫.୦ ^୫.୧ "Idelalisib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 October 2020. Retrieved 25 November 2021.
↑ "Zydelig Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 April 2021. Retrieved 25 November 2021.

[EPAR2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Zydelig EPAR". European Medicines Agency (EMA). Archived from the original on 23 October 2020. Retrieved 21 October 2020.

[2] "Clinical Pharmacology and Biopharmaceutics Review: Zydelig (idelalisib)" (PDF). U.S. Food and Drug Administration. p. 6. Archived (PDF) from the original on 28 April 2016. Retrieved 15 April 2016.

[PI2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Zydelig- idelalisib tablet, film coated". DailyMed. 22 October 2018. Archived from the original on 23 October 2020. Retrieved 21 October 2020.

[BNF81-4] ୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1029. ISBN 978-0857114105.

[AHFS2021-5] ୫.୦ ^୫.୧ "Idelalisib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 October 2020. Retrieved 25 November 2021.

[6] "Zydelig Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 April 2021. Retrieved 25 November 2021.

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