ଲୁଟେଟିଅମ (୧୭୭ଲୁ) ଅକ୍ସୋଡୋଟ୍ରିଓଟାଇଡ

ଲୁଟେଟିଅମ (୧୭୭ଲୁ) ଅକ୍ସୋଡୋଟ୍ରିଓଟାଇଡ
Clinical data
Trade names	Lutathera
Synonyms	Lutetium (177Lu) dotatate
AHFS/Drugs.com	monograph
data	EU EMA: yes; US DailyMed: Lutathera;
Routes of; administration	Intravenous
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Identifiers
	IUPAC name (177Lu)lutetium(3+) 2-[4-({[(1R)-1-{[(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-4-{[(1S,2R)-1-carboxy-2-hydroxypropyl]-C-hydroxycarbonimidoyl}-6,9,12,15,18-pentahydroxy-7-[(1R)-1-hydroxyethyl]-13-[(1H-indol-3-yl)methyl]-16-[(4-oxidophenyl)methyl]-1,2-dithia-5,8,11,14,17-pentaazacycloicosa-5,8,11,14,17-pentaen-19-yl]-C-hydroxycarbonimidoyl}-2-phenylethyl]-C-hydroxycarbonimidoyl}methyl)-7,10-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetate;
Chemical and physical data
Formula	C65H87LuN14O19S2
Molar mass	୧,୬୦୭.୫୮ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=C(C=C4)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)CN6CCN(CCN(CCN(CC6)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-])C(=O)NC(C(C)O)C(=O)O)O.[Lu+3];
	InChI InChI=1S/C65H90N14O19S2.Lu/c1-38(80)56-64(96)73-51(63(95)75-57(39(2)81)65(97)98)37-100-99-36-50(72-59(91)47(28-40-10-4-3-5-11-40)68-52(83)32-76-20-22-77(33-53(84)85)24-26-79(35-55(88)89)27-25-78(23-21-76)34-54(86)87)62(94)70-48(29-41-15-17-43(82)18-16-41)60(92)71-49(30-42-31-67-45-13-7-6-12-44(42)45)61(93)69-46(58(90)74-56)14-8-9-19-66;/h3-7,10-13,15-18,31,38-39,46-51,56-57,67,80-82H,8-9,14,19-30,32-37,66H2,1-2H3,(H,68,83)(H,69,93)(H,70,94)(H,71,92)(H,72,91)(H,73,96)(H,74,90)(H,75,95)(H,84,85)(H,86,87)(H,88,89)(H,97,98);/q;+3/p-3/t38-,39-,46+,47-,48+,49-,50+,51+,56+,57+;/m1./s1/i;1+2; Key:MXDPZUIOZWKRAA-PRDSJKGBSA-K;

ଲୁଟେଟିଅମ (^୧୭୭ଲୁ) ଅକ୍ସୋଡୋଟ୍ରିଓଟାଇଡ, ବେପାର ନାମ ଲୁଟାଥେରା, ହେଉଛି ଗ୍ୟାଷ୍ଟ୍ରୋଏଣ୍ଟେରୋପାନ‌‌କ୍ରିଆଟ୍ରିକ ନିଉରୋଏଣ୍ଡୋକ୍ରାଇନ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ଯାହା ସୋମାଟୋଷ୍ଟାଟିନ୍ ରିସେପ୍ଟରଗୁଡିକ ପ୍ରକାଶ କରିଥାଏ ।^[୪] ୯ ମାସରୁ ୨୮ ମାସ ପର୍ଯ୍ୟନ୍ତ ରୋଗ ସ୍ଥିର ରହିଲେ ଏହା ସମୟକୁ ଉନ୍ନତ ହେଲା ମନେ କରିବା ।^[୫] ଏହା ଏକ ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରକ୍ତରେ କମ୍ ଲିମ୍ଫୋସାଇଟ୍, ଯକୃତ ପ୍ରଦାହ, ରକ୍ତରେ ଅଧିକ ଶର୍କରା, କମ୍ ପୋଟାସିଅମ ଏବଂ ବାନ୍ତି ହୋଇପାରେ ।^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କମ୍ ପ୍ଲାଟେଲେଟ୍, କମ ଲୋହିତ ରକ୍ତ କଣିକା ଏବଂ ଥକ୍କାପଣ ହୋଇପାରେ ।^[୫] ଏହା ସୋମାଟୋଷ୍ଟାଟିନ୍ ରିସେପ୍ଟର ସହିତ ସଂଲଗ୍ନ ହୋଇ କାମ କରେ ଯାହା ଜୀବକୋଷକୁ ରେଡିଓଆକ୍ଟିଭିଟି ଦେଇଥାଏ ।^[୫]

୨୦୧୭ ମସିହାରେ ୟୁରୋପରେ ଏବଂ ୨୦୧୮ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ଚିକିତ୍ସା ପାଇଁ ଲୁଟେଟିୟମ୍ ( ^୧୭୭ ଲୁ) ଅକ୍ସୋଡୋଟ୍ରିଓଟାଇଡ ଅନୁମୋଦନ କରାଯାଇଥିଲା। ^[୫] ^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ଏହାର ଏକ ମାତ୍ରାର ମୂଲ୍ୟ ପ୍ରାୟ ୫୪,୦୦୦ ଡଲାର ଥିଲେ ।^[୬]

ଆଧାର

↑ "Lutathera EPAR". European Medicines Agency (EMA). Archived from the original on 11 December 2019. Retrieved 11 December 2019.
↑ "Lutathera 370 MBq/mL solution for infusion - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 9 July 2021. Retrieved 9 July 2021.
↑ ^୩.୦ ^୩.୧ "Lutathera- lutetium lu 177 dotatate injection". DailyMed. 4 May 2020. Archived from the original on 16 November 2020. Retrieved 8 November 2020.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "Lutetium Lu 177 Dotatate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 19 October 2021. Retrieved 24 November 2021.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ "Lutathera". Archived from the original on 11 December 2019. Retrieved 24 November 2021.
↑ "Lutathera Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 24 November 2021.

[Lutathera_EPAR-1] "Lutathera EPAR". European Medicines Agency (EMA). Archived from the original on 11 December 2019. Retrieved 11 December 2019.

[Lutathera_SmPC-2] "Lutathera 370 MBq/mL solution for infusion - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 9 July 2021. Retrieved 9 July 2021.

[PI2021-3] ୩.୦ ^୩.୧ "Lutathera- lutetium lu 177 dotatate injection". DailyMed. 4 May 2020. Archived from the original on 16 November 2020. Retrieved 8 November 2020.

[AHFS2021-4] ୪.୦ ^୪.୧ ^୪.୨ "Lutetium Lu 177 Dotatate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 19 October 2021. Retrieved 24 November 2021.

[EPAR2021-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ "Lutathera". Archived from the original on 11 December 2019. Retrieved 24 November 2021.

[6] "Lutathera Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 24 November 2021.

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