ଭୋରିନୋଷ୍ଟାଟ

ଭୋରିନୋଷ୍ଟାଟ
Clinical data
Pronunciation	Vorinostat /vɒˈrɪnoʊstæt/ vorr-IN-oh-stat; Zolinza (/zoʊˈlɪnzə/ zoh-LIN-zə
Trade names	Zolinza, Vorinostat MSD, others
Synonyms	Suberanilohydroxamic acid (SAHA)
AHFS/Drugs.com	monograph
MedlinePlus	a607050
data	US FDA: Vorinostat;
Pregnancy; category	US: D (Evidence of risk) ; ;
Routes of; administration	By mouth (capsules)
Legal status
Legal status	US: ℞-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	1.8–11%
Protein binding	~71%
Metabolism	Liver glucuronidation and β-oxidation; CYP system not involved
Metabolites	vorinostat O-glucuronide, 4-anilino-4-oxobutanoic acid (both inactive)
Elimination half-life	~2 hours (vorinostat and O-glucuronide), 11 hours (4-anilino-4-oxobutanoic acid)
Excretion	Kidney (negligible)
Identifiers
	IUPAC name N-Hydroxy-N'-phenyloctanediamide;
ECHA InfoCard	100.207.822
Chemical and physical data
Formula	C14H20N2O3
Molar mass	୨୬୪.୩୩ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(Nc1ccccc1)CCCCCCC(=O)NO;
	InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18) ; Key:WAEXFXRVDQXREF-UHFFFAOYSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Vorinostat

ଭୋରିନୋଷ୍ଟାଟ (ଇଂରାଜୀ ଭାଷାରେ Vorinostat), ବିକ୍ରୟ ନାମ ଜୋଲିଞ୍ଜା, ହେଉଛି ଏକ ଔଷଧ ଯାହା କ୍ୟୁଟାନିଅସଟି ସେଲ୍ ଲିମ୍ଫୋମା (CTCL) ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୩] ନିର୍ଦ୍ଦିଷ୍ଟ ଭାବରେ ଏହା ବ୍ୟବହୃତ ହୁଏ ଯେତେବେଳେ ରୋଗ ଚାଲୁ ରହେ, ଖରାପ ଦିଗକୁ ଯାଏ କିମ୍ବା ଅନ୍ୟ ଦୁଇଟି ଚିକିତ୍ସା ସମୟରେ କିମ୍ବା ପରେ ପୁନର୍ବାର ଫେରି ଆସେ ।^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ଥକାପଣ, ସ୍ୱାଦର ପରିବର୍ତ୍ତନ, କମ ରକ୍ତ ପ୍ଲାଟେଲେଟ୍, କେଶ ଝଡ଼ିବା, କାଶ ଏବଂ ଜ୍ୱର ହୋଇପାରେ ।^[୩] ଅନ୍ୟାନ୍ୟ ଭୟଙ୍କର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରକ୍ତ ଜମାଟ ବାନ୍ଧିବା ଏବଂ ଉଚ୍ଚ ରକ୍ତ ଶର୍କରା ହୋଇପାରେ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ । ^[୩] ଏହା ଏକ ହିଷ୍ଟୋନ୍ ଡିଆସିଟିଲେଜ ଇନହିବିଟର (HDI) ।^[୩]

୨୦୦୬ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଭୋରିନୋଷ୍ଟାଟ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୩] ୨୦୦୪ରେ ୟୁରୋପରେ ଏହାକୁ ଅନାଥ ଔଷଧ (orphan medication) ମାନ୍ୟତା ଦିଆଯାଇଥିବାବେଳେ ୨୦୦୯ରେ ଅନୁମୋଦନ ପାଇଁ ଆବେଦନ ପ୍ରତ୍ୟାହାର କରାଯାଇଥିଲା । ^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ଏହା ବାବଦ ମାସକୁ ପ୍ରାୟ ୧୪,୬୦୦ ଡଲାର ଖର୍ଚ୍ଚ ହୋଇଥାଏ ।^[୫]

ଆଧାର[ସମ୍ପାଦନା]

↑ "Withdrawal Assessment Report for Vorinostat MSD 100 mg Hard Capsules (vorinostat)" (PDF). European Medicines Agency. 23 October 2008. p. 9. Archived (PDF) from the original on 15 September 2016. Retrieved 1 September 2016.
↑ "Zolinza (vorinostat) Capsules. Full Prescribing Information" (PDF). Merck & Co., Inc., Whitehouse Station, NJ 08889, USA. Archived (PDF) from the original on 2 October 2016. Retrieved 1 September 2016.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ ^୩.୭ "Vorinostat Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 March 2016. Retrieved 16 September 2021.
↑ "Vorinostat MSD: Withdrawal of the marketing authorisation application". Archived from the original on 22 September 2021. Retrieved 16 September 2021.
↑ "Zolinza Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 June 2016. Retrieved 16 September 2021.

[1] "Withdrawal Assessment Report for Vorinostat MSD 100 mg Hard Capsules (vorinostat)" (PDF). European Medicines Agency. 23 October 2008. p. 9. Archived (PDF) from the original on 15 September 2016. Retrieved 1 September 2016.

[Zolinza_PI-2] "Zolinza (vorinostat) Capsules. Full Prescribing Information" (PDF). Merck & Co., Inc., Whitehouse Station, NJ 08889, USA. Archived (PDF) from the original on 2 October 2016. Retrieved 1 September 2016.

[AHFS2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ ^୩.୭ "Vorinostat Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 March 2016. Retrieved 16 September 2021.

[EMA2021-4] "Vorinostat MSD: Withdrawal of the marketing authorisation application". Archived from the original on 22 September 2021. Retrieved 16 September 2021.

[5] "Zolinza Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 14 June 2016. Retrieved 16 September 2021.

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