ସିନାକାଲସେଟ

ସିନାକାଲସେଟ
Clinical data
Trade names	Sensipar, Mimpara
AHFS/Drugs.com	monograph
MedlinePlus	a605004
data	EU EMA: yes; US DailyMed: Cinacalcet;
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	20 to 25%; increases if taken with food
Protein binding	93 to 97%
Metabolism	Liver (CYP3A4-, CYP2D6- and CYP1A2-mediated)
Elimination half-life	30 to 40 hours
Excretion	Kidney (80%) and fecal (15%)
Identifiers
	IUPAC name (R)-N-[1-(1-naphthyl)ethyl]-3-; [3-(trifluoromethyl)phenyl]propan-1-amine;
ECHA InfoCard	100.208.116
Chemical and physical data
Formula	C22H22F3N
Molar mass	୩୫୭.୪୨ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F;
	InChI InChI=1S/C22H22F3N/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3/t16-/m1/s1 ; Key:VDHAWDNDOKGFTD-MRXNPFEDSA-N ;
(verify)

ସିନାକାଲସେଟ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ସେନ୍ସିପାର, ଏହା ଏକ ମାଧ୍ୟମ ଯାହାଦ୍ୱାରା ସେକେଣ୍ଡାରୀ ହାଇପରପାରାଥାଇରଏଡିଜ୍ମ, ପାରାଥାଇରଏଡ କର୍କଟ ରୋଗ ଏବଂ ପ୍ରଥମିକ ହାଇପରପାରାଥାଇରଏଡିଜ୍ମ ରୋଗମାନଙ୍କର ଚିକିତ୍ସା କରାଯାଏ ।^[୪] ^[୫] ଡାଏଲିସିସ ଆବଶ୍ୟକ ହେଉଥିବା ସେକେଣ୍ଡାରୀ ହାଇପରପାରାଥାଇରଏଡିଜ୍ମରେ ଏହା ବ୍ୟବହୃତ ହୁଏ; ପାରାଥାଇରଏଡ୍ କର୍କଟ ରୋଗରେ ଏହା ଉଚ୍ଚ ରକ୍ତ କ୍ୟାଲସିୟମ ସ୍ତରର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୬] ଏହାକୁ ଖାଦ୍ୟ ସହିତ ପାଟିରେ ନିଆଯାଏ ।^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ ଓ ବାନ୍ତି ହୋଇପାରେ ।^[୫] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଉପର ପାକଅନ୍ତନଳୀରୁ ରକ୍ତସ୍ରାବ, କମ ରକ୍ତ କ୍ୟାଲସିୟମ୍ ସ୍ତର, ନିମ୍ନ ରକ୍ତଚାପ ଏବଂ ଆଡାଇନାମିକ ଅସ୍ଥି ରୋଗ ହୋଇପାରେ। ^[୪] କମ୍ ରକ୍ତ କ୍ୟାଲସିୟମ୍ ଥିବା ଲୋକଙ୍କଠାରେ ଏହା ବ୍ୟବହାର କରାଯିବା ଉଚିତ୍ ନୁହେଁ । ^[୫] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ।^[୭] ଏହା ଏକ କାଲସିମାଇମେଟିକ୍ ଔଷଧ, ଅର୍ଥାତ୍ ଏହା ଶରୀରରେ କ୍ୟାଲସିୟମର କାର୍ଯ୍ୟକ୍ରମକୁ ଅନୁକରଣ କରେ ।^[୫]

୨୦୦୪ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ସିନାକାଲସେଟ ବ୍ୟବ‌ହାର ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ^[୫] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୩୦ମିଗ୍ରାର ୩୦ଟି ବଟିକାର ମୂଲ୍ୟ ୨୦୨୨ ସୁଦ୍ଧା ପ୍ରାୟ ୧୭ ଡଲାର ଥିଲା ।^[୮] ଯୁକ୍ତରାଜ୍ୟରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ପ୍ରାୟ ୧୧୪ ପାଉଣ୍ଡ ଅଟେ ।^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Cinacalcet (Sensipar) Use During Pregnancy". Drugs.com. 19 July 2019. Archived from the original on 7 December 2019. Retrieved 24 December 2019.
↑ "Sensipar Tablets". NPS MedicineWise. 1 May 2018. Archived from the original on 7 December 2019. Retrieved 7 December 2019.
↑ "Mimpara 30 mg Film-coated Tablets - Summary of Product Characteristics (SmPC)". electronic medicines compendium (emc). 8 July 2019. Archived from the original on 7 December 2019. Retrieved 7 December 2019.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ "Sensipar- cinacalcet hydrochloride tablet, coated". DailyMed. 5 December 2019. Archived from the original on 25 September 2020. Retrieved 24 December 2019.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ "Mimpara EPAR". European Medicines Agency (EMA). 22 August 2019. Archived from the original on 24 December 2019. Retrieved 23 December 2019. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ ^୬.୦ ^୬.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1093. ISBN 978-0857114105.
↑ "Cinacalcet (Sensipar) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 7 December 2019. Retrieved 5 January 2022.
↑ ^୮.୦ ^୮.୧ "Cinacalcet Prices and Cinacalcet Coupons - GoodRx". GoodRx. Retrieved 5 January 2022.

[Drugs.com_Pregnancy-1] ୧.୦ ^୧.୧ "Cinacalcet (Sensipar) Use During Pregnancy". Drugs.com. 19 July 2019. Archived from the original on 7 December 2019. Retrieved 24 December 2019.

[NPS_Sensipar-2] "Sensipar Tablets". NPS MedicineWise. 1 May 2018. Archived from the original on 7 December 2019. Retrieved 7 December 2019.

[Mimpara_SmPC-3] "Mimpara 30 mg Film-coated Tablets - Summary of Product Characteristics (SmPC)". electronic medicines compendium (emc). 8 July 2019. Archived from the original on 7 December 2019. Retrieved 7 December 2019.

[PI2022-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ "Sensipar- cinacalcet hydrochloride tablet, coated". DailyMed. 5 December 2019. Archived from the original on 25 September 2020. Retrieved 24 December 2019.

[EPAR2022-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ "Mimpara EPAR". European Medicines Agency (EMA). 22 August 2019. Archived from the original on 24 December 2019. Retrieved 23 December 2019. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[BNF81-6] ୬.୦ ^୬.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1093. ISBN 978-0857114105.

[7] "Cinacalcet (Sensipar) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 7 December 2019. Retrieved 5 January 2022.

[GX2022-8] ୮.୦ ^୮.୧ "Cinacalcet Prices and Cinacalcet Coupons - GoodRx". GoodRx. Retrieved 5 January 2022.

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