ପ୍ରିଲୋକେନ

ପ୍ରିଲୋକେନ
Clinical data
Pronunciation	/ˈpraɪləˌkeɪn/
Trade names	Citanest, Prilotekal, others
AHFS/Drugs.com	monograph
MedlinePlus	a603026
data	EU EMA: yes; US DailyMed: Prilocaine;
Pregnancy; category	AU: A ; US: B (No risk in non-human studies) ;
Routes of; administration	Subcutaneous
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Protein binding	55%
Metabolism	Liver and kidney
Elimination half-life	10-150 minutes, longer with impaired liver or kidney function
Identifiers
	IUPAC name (RS)-N-(2-methylphenyl)-N2-propylalaninamide;
ECHA InfoCard	100.010.871
Chemical and physical data
Formula	C13H20N2O
Molar mass	୨୨୦.୩୨ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	37 to 38 °C (99 to 100 °F)
	SMILES O=C(Nc1ccccc1C)C(NCCC)C;
	InChI InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16) ; Key:MVFGUOIZUNYYSO-UHFFFAOYSA-N ;
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ଇଂରାଜୀ ଲିଙ୍କ

https://or.wikipedia.org/wiki/Prilocaine

ପ୍ରିଲୋକେନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ସାଇଟାନେଷ୍ଟର, ହେଉଛି ଏକ ସ୍ଥାନୀୟ ନିଶ୍ଚେତକ ଯାହା ଏକ ନିର୍ଦ୍ଦିଷ୍ଟ କ୍ଷେତ୍ର ଯେପରିକି ସ୍ନାୟୁ ଅବରୋଧ କିମ୍ବା ମେରୁଦଣ୍ଡର ଏକ ଅଂଶ ଉପରେ ନିଶ୍ଚେତକ ଭାବରେ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ^[୩] ଏହା ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୪] ଏହା ଏକ ଲିଡୋକାଇନ/ପ୍ରିଲୋକାଇନ କ୍ରିମ୍ ଭାବରେ ମଧ୍ୟ ଉପଲବ୍ଧ ହେଉଛି ।^[୩]

ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡ ବୁଲାଇବା, ଉଚ୍ଚ ରକ୍ତଚାପ, ନିମ୍ନ ରକ୍ତଚାପ, ବାନ୍ତି, ଏବଂ ଅନିୟମିତ ହୃତ୍ ସ୍ପନ୍ଦନ ହୋଇପାରେ ।^[୩] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମେଥେମୋଗ୍ଲୋବିନେମିଆ ଏବଂ ହୃଦ୍‌ରୋଧ ହୋଇପାରେ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଅପେକ୍ଷାକୃତ ସୁରକ୍ଷିତ ଥିବା ପରି ଜଣାଯାଏ ।^[୫] ଏହା ଏକ ଆମିଡପ୍ରକାରର ସ୍ଥାନୀୟ ନିଶ୍ଚେତକ ।^[୩]

୧୯୬୫ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ପ୍ରିଲୋକେନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ୧% ଦ୍ରବଣ ବିଶିଷ୍ଟ ୫୦ ମିଲି ପ୍ରିଲୋକେନର ମୂଲ୍ୟ ପ୍ରାୟ ୫ ପାଉଣ୍ଡ ।^[୩] ୨୦୧୨ ସୁଦ୍ଧା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଉତ୍ପାଦନ ବନ୍ଦ ହୋଇଯାଇଛି; ^[୬] ଯଦିଓ ଏହା ପୂର୍ବରୁ ୪% ଦ୍ରବଣ ଥିବା ୧.୮ ମିଲି ପ୍ରିଲୋକେନ ପାଇଁ ପ୍ରାୟ ୧ ଡଲାର ଖର୍ଚ୍ଚ ହୋଇଥାଏ ।^[୭]

ଆଧାର

↑ "Prilocaine". Merriam-Webster Dictionary.
↑ "DailyMed - CITANEST PLAIN- prilocaine hydrochloride injection, solution". dailymed.nlm.nih.gov. Archived from the original on 30 October 2021. Retrieved 29 October 2021.
1 2 3 4 5 6 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1409. ISBN 978-0857114105.
1 2 "Prilocaine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 October 2021. Retrieved 29 October 2021.
↑ Giglio, JA; Lanni, SM; Laskin, DM; Giglio, NW (February 2009). "Oral health care for the pregnant patient". Journal (Canadian Dental Association). 75 (1): 43–8. PMID 19239743.
↑ "Determination That CITANEST (Prilocaine Hydrochloride) Injection, 1%, 2%, and 3%, and CITANEST PLAIN (Prilocaine Hydrochloride) Injection, 4%, Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness". Archived from the original on 9 November 2020. Retrieved 29 October 2021.
↑ "Citanest HCl Plain Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 May 2021. Retrieved 29 October 2021.

[1] "Prilocaine". Merriam-Webster Dictionary.

[PI2021-2] "DailyMed - CITANEST PLAIN- prilocaine hydrochloride injection, solution". dailymed.nlm.nih.gov. Archived from the original on 30 October 2021. Retrieved 29 October 2021.

[BNF81-3] 1 2 3 4 5 6 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1409. ISBN 978-0857114105.

[AHFS2021-4] 1 2 "Prilocaine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 October 2021. Retrieved 29 October 2021.

[5] Giglio, JA; Lanni, SM; Laskin, DM; Giglio, NW (February 2009). "Oral health care for the pregnant patient". Journal (Canadian Dental Association). 75 (1): 43–8. PMID 19239743.

[6] "Determination That CITANEST (Prilocaine Hydrochloride) Injection, 1%, 2%, and 3%, and CITANEST PLAIN (Prilocaine Hydrochloride) Injection, 4%, Were Not Withdrawn From Sale for Reasons of Safety or Effectiveness". Archived from the original on 9 November 2020. Retrieved 29 October 2021.

[7] "Citanest HCl Plain Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 May 2021. Retrieved 29 October 2021.

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