ପୋଡୋଫାଇଲୋଟକ୍ସିନ

ପୋଡୋଫାଇଲୋଟକ୍ସିନ
Clinical data
Trade names	Condylox, Warticon, Wartec, others
Synonyms	Podofilox, (5R,5aR,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
AHFS/Drugs.com	monograph
MedlinePlus	a684055
Pregnancy; category	C;
Pharmacokinetic data
Elimination half-life	1.0 to 4.5 hours.
Identifiers
	IUPAC name (10R,11R,15R,16R)-16-hydroxy-10-(3,4,5-trimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.03,7.011,15]hexadeca-1,3(7),8-trien-12-one;
ECHA InfoCard	100.007.502
Chemical and physical data
Formula	C22H22O8
Molar mass	୪୧୪.୪୧ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	183.3 to 184 °C (361.9 to 363.2 °F)
	SMILES COc1cc(cc(c1OC)OC)[C@@H]2c3cc4c(cc3[C@@H]([C@@H]5[C@@H]2C(=O)OC5)O)OCO4;
	InChI InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1 ; Key:YJGVMLPVUAXIQN-XVVDYKMHSA-N ;
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ପୋଡୋଫାଇଲୋଟକ୍ସିନ ( ପିପିଟି ), ଯାହାକୁ ପୋଡୋଫାଇଲକ୍ସ ମଧ୍ୟ କୁହାଯାଏ, ଏହା ଏକ ଔଷଧ ଯାହା ଯୌନାଙ୍ଗ ଭାତୁଡ଼ି ଏବଂ ମୋଲୁସ୍କମ କୋଣ୍ଟାଜିଓସମ ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ^[୧] ବାହ୍ୟ ୱାର୍ଟ ବିନା ପାପିଲୋମା ଭୂତାଣୁ ସଂକ୍ରମଣ ପାଇଁ ଏହି ଔଷଧ ଦେବାକୁ ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୨] ଏହା ସ୍ୱାସ୍ଥ୍ୟ ସେବା ପ୍ରଦାନକାରୀ କିମ୍ବା ରୋଗୀ ନିଜେ ପ୍ରଭାବିତ ଚର୍ମରେ ପ୍ରୟୋଗ କରନ୍ତି ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପ୍ରୟୋଗ ସ୍ଥାନରେ ଜ୍ୱାଳା, ଯନ୍ତ୍ରଣା ଏବଂ ଲାଲିମା ହୋଇପାରେ ।^[୨] ଏହା ପୋଡୋଫିଲମରୁ ବାହାର କରାଯାଇଥିବା ଏକ ଅଣ- ଆଲକାଲଏଡ୍ ଟକ୍ସିନ୍ ଲିଗନିନ ।^[୩] ପୋଡୋଫାଇଲମ ରେଜିନ ଭାବରେ ଜଣାଶୁଣା ଏକ କମ ବିଶୋଧିତ ଦ୍ରବ୍ୟ ମଧ୍ୟ ଉପଲବ୍ଧ, କିନ୍ତୁ ଏହାର ଅଧିକ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ଅଛି ।^[୪]^[୫]

ପୋଡୋଫାଇଲୋଟକ୍ସିନ ପ୍ରଥମେ ୧୮୮୦ ମସିହାରେ ପୃଥକ କରାଯାଇଥିଲା ।^[୬] ୧୯୯୦ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଏହା ଅନୁମୋଦିତ ହୋଇଥିଲା।^[୨] ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ପୋଡୋଫାଇଲମ ରେଜିନ ବଦଳର ଏହାର ନାମ ଲିପିବଦ୍ଧ ଅଛି ।^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୩.୫ ମିଲିର ଏକ ବୋତଲର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୩୦ ଡଲାର ଥିଲା ।^[୮] ଏହା ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ କଣ୍ଡିଲାଇନ ଏବଂ ୱାର୍ଟିକନ ବ୍ରାଣ୍ଡ ନାମରେ ବିକ୍ରି ହୁଏ | ^[୧]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Podophyllotoxin for anogenital warts; Podophyllotoxin info". patient.info. Archived from the original on 2018-05-07. Retrieved 2018-05-06.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Podofilox". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
↑ Xu H, Lv M, Tian X (2009). "A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007". Current Medicinal Chemistry. 16 (3): 327–49. doi:10.2174/092986709787002682. PMID 19149581.
↑ "Podophyllum Resin". The American Society of Health-System Pharmacists. Archived from the original on 22 December 2016. Retrieved 8 December 2016.
↑ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 307. hdl:10665/44053. ISBN 9789241547659.
↑ Cragg GM, Kingston DG, Newman DJ (2011). Anticancer Agents from Natural Products, Second Edition (2 ed.). CRC Press. p. 97. ISBN 9781439813836. Archived from the original on 2021-07-01. Retrieved 2021-10-04.
↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
↑ "Condylox Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 29 September 2016. Retrieved 28 October 2021.

[Pt2021-1] ୧.୦ ^୧.୧ ^୧.୨ "Podophyllotoxin for anogenital warts; Podophyllotoxin info". patient.info. Archived from the original on 2018-05-07. Retrieved 2018-05-06.

[AHFS2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Podofilox". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.

[3] Xu H, Lv M, Tian X (2009). "A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007". Current Medicinal Chemistry. 16 (3): 327–49. doi:10.2174/092986709787002682. PMID 19149581.

[AHFS2016R-4] "Podophyllum Resin". The American Society of Health-System Pharmacists. Archived from the original on 22 December 2016. Retrieved 8 December 2016.

[WHO2008-5] World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 307. hdl:10665/44053. ISBN 9789241547659.

[Gord2011-6] Cragg GM, Kingston DG, Newman DJ (2011). Anticancer Agents from Natural Products, Second Edition (2 ed.). CRC Press. p. 97. ISBN 9781439813836. Archived from the original on 2021-07-01. Retrieved 2021-10-04.

[WHO22nd-7] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[8] "Condylox Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 29 September 2016. Retrieved 28 October 2021.

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